Li, C.Y., Cao, L.S., Zeng, Q.T., et al. (2005) Taurine may prevent diabetic rats from developing cardiomyopathy also by down regulating angiotensinⅡtype-2 receptor expression. Cardiovascular Drugs and Therapy, 19, 105-112. doi:10.1007/s10557-005-0443-x

has been cited by the following article:

• TITLE: Uncoupling protein 2 regulates myocardial apoptosis via the diabetogenic action of streptozotocin

  AUTHORS: Xiu-Zhen Li, Ruo-Yun Tan, Xiang Lu

  KEYWORDS: Uncoupling Protein 2; Diabetes; Myocardium; Apoptosis

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.7, July 28, 2011

  ABSTRACT: Objective: Determine the role of uncoupling protein 2 (UCP2) in the myocardial apoptosis of diabetic mellitus（DM）. Methods: DM animal models were induced by streptozotocinon (STZ) on UCP2 knock-out mice (UCP2KO) and wild-type mice (WT), which were reared for 7 and 28 days after successful modeling, respectively. The expressions of relative protein for myocardial apoptosis, pro-caspase-9, were investigated using western blot. However, the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) was used to explain apoptosis at the DNA level. Results: Image analysis showed that the expression of pro-caspase-9 protein levels increased slightly in UCP-/- + DM-7-day group comparing with DM-7-day group (P > 0.05). The expression of pro-caspase-9 protein levels increased significantly (P