Spasov, A.A., Yozhitsa, I.N. and Bugaeva, L.I. (1999) Benzimidazole Derivatives: Spectrum of Pharmacological Activity and Toxicological Properties (A Review). Pharmaceutical Chemistry Journal, 33, 232-243.
ABSTRACT: A fast, high efficiency and environmentally friendly procedure for the synthesis of 2-aryl benzim-idazole derivatives has been reported. Reaction between 1,2-phenylenediamine derivatives and arylidene malononitrile under aqueous media and also solvent-free conditions generates 2-aryl benzimidazole derivatives with a high yield.