Hassan-Smith, Z.K., Morgan, S.A., Sherlock, M., Hughes, B., Taylor, A.E, Lavery, G.G, Tomlinson, J.W. and Stewart, P.M. (2015) Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression across Healthy Aging. The Journal of Clinical Endocrinology & Metabolism, 100, 2673-2681.
http://dx.doi.org/10.1210/jc.2015-1516

has been cited by the following article:

• TITLE: Activity of Salivary 11β-Hydroxysteroid Dehydrogenase Type 2 Becomes the Index for the Continuous Strength Exercise to Prevent Locomotive Syndrome in Japan

  AUTHORS: Noboru Hasegawa, Maki Ohara, Miyako Mochizuki

  KEYWORDS: Salivary Cortisol, Salivary Cortisone, 11β--Hydroxysteroid Dehydrogenase, Muscle Weight, Strength Exercise

  JOURNAL NAME: Health, Vol.7 No.10, October 29, 2015

  ABSTRACT: The Japanese Orthopedic Association proposed a concept called locomotive syndrome (LS) to identify middle-aged and older adults at high risk of requiring health care services because of problems with locomotion-associated lower muscle mass. To prevent LS, it is important to increase muscle mass and muscle strength in middle-age by continuous resistance training. A total of 38 men and women were assessed at baseline and 6 months. Body composition, physical strength and salivary cortisol and cortisone were analyzed. The exercise intervention program was performed by individual muscle endurance level. Body weight, muscle weight and basal metabolism were increased after exercise intervention. The 30-second sit-up test and 3-minute walking were increased, and the 10-time sit-to-stand was decreased significantly. This may be related to increase of leg and abdominal muscular strength. The exercise intervention program increased salivary 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activities significantly. These results suggested that 11β-HDS2 became the index for the increase of muscular strength to prevent LS.