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Kitada, Y., Wan, W., Matsui, K., Matsui, K., Shimizu, S. and Yamaguchi, N. (2000) Regulation of Peripheral White Blood Cells in Numbers and Functions through Hot-Spring Bathing during a Short Term—Studies in Control Experiments. Journal of Japanese Society Balneology Climatology Physiological Medicine, 63, 151-164.

has been cited by the following article:

  • TITLE: Single Cellular Algae Digestive Supplement Designed by Yeast & Lactobacillus Rearranged Leukocyte Subsets through Activation of Complement Components

    AUTHORS: Hitoshi Kubota, Nurmuhamamt Amat, Dilxat Yimit, Parida Hoxur, Nobuo Yamaguchi

    KEYWORDS: Family Poaceae, Chlorella pyrenoidosa, Fermentation, Yeast, Lactobacillus, Cancer Chemotherapeutic Agent, Compromised Host, Lipidosis, Cardiovascular Disease, Diabetes Meritus, Immune Augmentation

    JOURNAL NAME: Open Journal of Immunology, Vol.5 No.3, August 28, 2015

    ABSTRACT: A plant fermentation was carried out by Yeast and Lactobacilli against single cellular algae (f-Chlorella). These materials were proved by as safe in animal safety experiment. We sought to look into changes of immune-competent cells that commonly utilized f-Chlorella including after administration of immno-suppressed animals. The effects by f-Chlorella on the regurational effect to the host were measured. Our results showed that f-Chlorella regulated the level of lymphocytes, while conventional-Chlorella worked to adjust the level of granulocytes. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in the peripheral blood. In rodents, immune-compromised host as well as normal animal were prepared with cancer chemotherapeutic agent (Mytomycin-C), and then tried to rescue the immune-competent rebel. Our observations showed that both Chlorella derivatives regulated in number and functions. The effect was more prominent in f-Chlorella than that of conventional one. We discussed the significance and mechanism of f-Chlorella on the level of leukocyte subsets in number and function. These effects were considered to bring the potential elevation of antibody secreting cell by the localized heamolysis in gel method. We also proposed an idea that exhibited tonic effects were brought via activating the complement components in the serum. Moreover, we tried to access further to the anti-oxidative activities of this f-Chlorella. This modification brought to the significant lifted up for immune competent cells and anti-oxidative activity for phagocytic cells.