Why Us? >>

  • - Open Access
  • - Peer-reviewed
  • - Rapid publication
  • - Lifetime hosting
  • - Free indexing service
  • - Free promotion service
  • - More citations
  • - Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.


Contact Us >>

WhatsApp  +86 18163351462(WhatsApp)
Paper Publishing WeChat
Book Publishing WeChat
(or Email:book@scirp.org)

Article citations


da Cunha, J., Ferreira Maselli, L.M., Treitinger, A., Monteiro, A.M., Gidlund, M., Maranhão, R.C., Spada, C. and Bydlowski, S.P. (2013) Serum Levels of IgG Antibodies against Oxidized LDL and Atherogenic Indices in HIV-1-Infected Patients Treated with Protease Inhibitors. Clinical Chemistry and Laboratory Medicine, 51, 371-378. http://dx.doi.org/10.1515/cclm-2012-0225

has been cited by the following article:

  • TITLE: The Effects of Treatment on Serum Hepcidin and Iron Homeostasis in HIV-1-Infected In-dividuals

    AUTHORS: Joel da Cunha, Luciana Morganti Ferreira Maselli, Jovino dos Santos Ferreira, Celso Spada, Sérgio Paulo Bydlowski

    KEYWORDS: Hepcidin, Iron Homeostasis, HIV-1, HAART, ART-Naïve, CD4+ T-Cells

    JOURNAL NAME: World Journal of AIDS, Vol.5 No.3, August 26, 2015

    ABSTRACT: Background: Hepcidin is the principal regulator of iron absorption and its tissue distribution. Its correlation with iron homeostasis in individuals infected with human immunodeficiency virus type-1 (HIV-1) treated with different regimens of highly active antiretroviral therapy (HAART) was investigated. Methods: Serum hepcidin levels were determined in 448 volunteers. Of these, 372 were HIV-1-infected individuals, and 93 did not receive HAART (ART-naïve) while 279 received HAART consisting of a non-nucleoside reverse transcriptase inhibitor (NNRTI-based) and protease inhibitors (PI-based); both were used in association with a nucleoside reverse transcriptase inhibitor (NRTI). Seventy-six additional HIV-1 seronegative individuals were enrolled in the study. The following parameters were quantified: hematological parameters, iron biomarkers and markers of infection (CD4+ and CD8+ T-cells), and HIV-1 RNA (viral load). Results: Serum hepcidin, iron and ferritin levels, as well as the marker of infection, CD4+ T-cells, were significantly lower in the ART-naïve group compared with other groups. Additionally, transferrin saturation, iron binding capacity, hemoglobin level and erythrocyte level were not significantly different, and anemia was not observed in the different groups. Conclusions: HIV-1 infection affected serum hepcidin, iron and ferritin levels in the ART-naïve group, and the different HAART regimens restored the levels of hepcidin and iron homeostasis in HIV-1-infected individuals who have undetectable HIV-1 RNA levels.