TITLE:
A Report on the Death of Mixed Infection of HEV and HBV
AUTHORS:
Yonggang Qu, Yujian Zheng, Chuangfu Chen, Guangze Zhu, Ningyi Jin
KEYWORDS:
Hepatitis E Virus, Hepatitis B Virus, Mixed Infection
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.3,
March
30,
2015
ABSTRACT:
Mixed infection with hepatitis E virus
(HEV) in patients with chronic hepatitis B virus (HBV) infection is frequent.
HEV mixed infection often leads to activation of hepatic pathological changes
and worsens the inflammatory activity. However, it is not known clearly how
these two types of virus influence each other in human body. Intensive investigation
has revealed that HEV mixed infection inhibits HBV replication. We have just
encountered a relative rare case. The patient who was a HBV carrier and was
infected by HEV. Before he was infected by the HEV, the measurement of his HBV
DNA fixed quantity examination on fluorescence was 3 copies/ml; his
routine biochemistry was normal; and his anti HEV-IgM and anti-HEV-IgG appeared
to be negative reaction. After he was infected by HEV, his routine biochemistry
increased, and the measurement of his HBV DNA fixed quantity examination on
fluorescence was 8.51 × 105 copies/ml. It indicated that the replication of HBV
was activated after the patient infected HEV. Finally, he was dead. This case
revealed that HEV mixed infection may activate the replication of HBV, not
inhibit HBV replication, and demonstrated the needs for further studies about
the mechanism of the interaction of the two viruses.