TITLE:
Incidence and Clinical Characteristics of Deep Vein Thrombosis (DVT) after Total Knee Arthroplasty (TKA) with DVT Chemoprophylaxis
AUTHORS:
Yong Sung Won, Mihyeong Kim, Kang Woong Jun, Woo Seok Nam, Sanghyun Ahn, Jeong-Kye Hwang, Sang-Dong Kim, Sun-Cheol Park, Sang Seob Yun, Won-Chul Lee, Jang-Sang Park, Jang Yong Kim
KEYWORDS:
Venous Thromboembolism, Thromboprophylaxis, Low Molecular Weight Heparin, Anticoagulation, Total Knee Arthroplasty
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.4 No.11,
October
22,
2014
ABSTRACT: Objective: Deep
vein thrombosis (DVT) after total knee arthroplasty (TKA) is very common and
leading cause of death due to this procedure. The objective of this study was
to investigate the incidence and clinical characteristics of DVT after TKA with
DVT chemoprophylaxis. Methods: This is a prospective cohort study in single
institution. The patients received postoperative DVT chemoprophylaxis (low molecular
weight heparin (LMWH) or Fondaparinux), followed by duplex ultrasonography to
check for DVT 1 - 2 weeks after TKA. The clinical characteristics were
summarized and analysed by chi-square test and regression analysis. Results:
Five hundred and thirty four patients were enrolled from January 2007 to
December 2010. DVT chemoprophylaxis was administered in 524 (98.1%) of the 534
patients. DVT occurred in 9 subjects (1.69%); 8 subjects had DVT in the leg,
and 1 subject had a pulmonary embolism. Among them, asymptomatic DVT was observed
in 5 patients (0.94%). Univariate analysis showed that surgical methods
(revision, P = 0.0007), body mass index (BMI) (>25, P = 0.0028), low
platelet count (less than 150 × 103, P = 0.0219),
time in the intensive care unit (ICU) (P