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Brown, G.W. and Harris, T.O. (1989) Depression. In Brown, G.W. and Harris, T.O., Eds., Life Events and Illness, The Guilford, New York, 49-93.

has been cited by the following article:

  • TITLE: Effect of Citrus aurantium L. Essential Oil and Its Interaction with Fluoxetine on Anxiety in Male Mice

    AUTHORS: Sorin Saketi, Maryam Bananej, Mahsa Hadipour Jahromy

    KEYWORDS: Anxiety, Essential Oil, Citrus aurantium L., Fluoxetine

    JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.4 No.7, July 9, 2014

    ABSTRACT: Anxiety is a very common mental disorder among neurological diseases. Some herbs have soothing effects and play an important role in reducing anxiety. The purpose of this study is to investigate the effect of Citrus aurantium L. essential oil on anxiety and its interference with serotonergic pathway. Sixty male mice were assigned into control, sham (saline and olive oil), and experimental groups. Intraperitoneal injection of Citrus aurantium L. essential oil was applied at doses of 0.5, 2.5, and 5 percent for 5 days. In another set of experiments, after intraperitoneal injection of Citrus aurantium L. essential oil at doses of 0.5, 2.5, and 5 percent for 5 days, on the 5th day, 30 minutes before applying essential oil, fluoxetine (2 mg/kg) was injected. Then, the anxiety-related behavior was assessed using elevated plus maze test. The results revealed that injection of essential oil of Citrus aurantium L. alone or along with fluoxetine led to increasing the number of entries into the open arms and the time spent in open arms that was significantly different compared with control and sham groups (PCitrus aurantium L. essential oil can reduce the anxiety in male mice and due to fluoxetin potentiation and maximum response observed, the herb may express its anxiolytic effects in part, via serotonergic system.