TITLE:
Aspirin resistance in young men with Type 2 diabetes
AUTHORS:
Subhashini Yaturu, Emmy Dier, Huadong Cui, Shaker Mousa
KEYWORDS:
Aspirin; Aspirin Resistance; Type 2 Diabetes; Men; CRP; IL-6; Adiponectin; Body Composition; Abdominal Fat
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.1,
February
25,
2014
ABSTRACT:
Objective: Aspirin
resistance (AR) or poor response to aspirin is said to be high among subjects
with diabetes and more so in patients with poor glycemic control. The aim of
our study was to evaluate the prevalence of AR among subjects with diabetes
with moderate glycemic control and its association with inflammatory markers
and cytokines. Design: This is a
single-center open-label prospective clinical study. Methods: The study included 142 young male veterans (mean age of
49years) with Type 2 diabetes, with HbA1C of 7.7 ± 1.1. Urinary 11-dehydro-thromboxane
beta-2 (11DhTx2) concentrations measured by immunoassay are the primary outcome
measures. Results: Urinary
11DhTxB2 levels ≥ 1500 pg/mg of creatinine is considered as AR.
Approximately 53% of subjects had AR. There are no significant differences in
the clinical parameters, such as age, history of hypertension or BMI, waist to
hip ratio; as well as biochemical parameters, such as HbA1C, lipid parameters
or serum creatinine, between subjects with or without AR. Levels of 11DhTxB2 /cre correlated with history of CAD, abdominal fat content and IL-6 levels (p