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K. G. Reddy, R. N. Nair, H. M. Sheehan and J. M. Hodgson, “Evidence That Selective Endothelial Dysfunction May Occur in the Absence of Angiographic or Ultrasound Atherosclerosis in Patients with Risk Factors for Atherosclerosis,” Journal of the American College of Cardiology, Vol. 23, No. 4, 1994, pp. 833-843.

has been cited by the following article:

  • TITLE: Effects of Statin Therapy on Endothelial Function in Asymptomatic Metabolic Syndrome

    AUTHORS: Boochi Babu Mannuva, Rajasekhar Durgaprasad, Vanajakshamma Velam, Vinod Kumar Mustyala, Latheef Kasala, Ashok Thakkar

    KEYWORDS: Metabolic Syndrome; Endothelial Dysfunction; Flow-Mediated Dilation; Brachial Artery; Statin

    JOURNAL NAME: International Journal of Clinical Medicine, Vol.5 No.4, February 15, 2014

    ABSTRACT: Context: Endothelial dysfunction is an early predictor of adverse cardiovascular events. The present study evaluated asymptomatic metabolic syndrome (MS) patients with brachial artery endothelial dysfunction to determine whether a reversal of endothelial dysfunction occurs with statin treatment. Aim: To evaluate the short term effects of statins on endothelial function in asymptomatic metabolic syndrome patients. Methodology: This was a prospective, single centre, case-control study. We evaluated 50 recently diagnosed newly detected asymptomatic MS patients who underwent an assessment of endothelial function by brachial artery flow-mediated dilation (FMD) before and after treatment with 40 mg atorvastatin for one week. Results: A total of 50 MS patients, including 36 (62%) females and 14 (38%) males, were included in the study. The mean age of the patients was 49.70 ± 8.84 y. We identified a significant difference between cases and age- and sex-matched controls regarding baseline brachial artery FMD% (6.73 ± 2.55 vs. 11.03 ± 1.85, respectively; p lations were detected between FMD% and HDL-cholesterol (r = -0.34, p = 0.01), fasting blood sugar (r = -0.40, p = 0.004), and systolic blood pressure (r = -0.34, p = 0.015). Multiple linear regression analysis indicated that HDL-cholesterol was an independently associated factor for FMD. MS patients treated with 40 mg atorvastatin for one week showed a significant improvement in brachial artery FMD% (6.73 ± 2.55 before treatment vs. 10.19 ± 3.01 after treatment, p dothelial function in MS patients.