TITLE:
Chronic Administration of the Resveratrol or N-PEP-12 Ameliorates the Endothelial Dysfunction in Aging Rats
AUTHORS:
Gonzalo Flores, Josue Hernández-Cabrera, Celeste Santamaria-Juarez, Rubén Antonio Vázquez-Roque, Elizabeth Monserrat-Hernández, Ma. De Jesús Gómez-Villalobos, Jorge Flores-Hernández, Fausto Atonal-Flores, José Gustavo López-López
KEYWORDS:
Resveratrol; N-PEP-12, Aging; Vascular Endothelium; Blood Pressure
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.1,
January
16,
2014
ABSTRACT:
Here we investigated the effects of chronic treated with resveratrol, a
polyphenol (3,4’,5-trihydroxystilbene) found in more than 70 plant species and food products such as red grapes,
berries and peanuts, or N-PEP-12, a mix of peptides, on arteries in aging rats.
Aging rats have shown endothelial dysfunction. Aged Sprague-Dawley rats (18
months old) were treated with resveratrol (20 mg/kg/day by gavage) or N-PEP-12
(60 mg/kg/day by gavage) for 10 weeks. 24 hours after the last
administration of resveratrol or N-PEP-12, the animals were weighed and
diastolic and systolic blood pressure was measured by tail-cuff
plethysmography. Thoracic and abdominal aorta artery segments were obtained
from resveratrol-, N-PEP-12-and vehicle-treated rats and were mounted in isometric
tension for isolated vessels. We found that resveratrol and N-PEP-12
improved acetylcholine-induced relaxation in the old animals. These results suggest that chronic administration of resveratrol or
N-PEP-12 may in part reduce endothelial dysfunction in the aging.