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has been cited by the following article:

• TITLE: AKT3 rSNPs, Transcriptional Factor Binding Sites and Human Disease

  AUTHORS: Norman E. Buroker

  KEYWORDS: AKT3; rSNPs; TFBS; Human Disease

  JOURNAL NAME: Open Journal of Blood Diseases, Vol.3 No.4, December 13, 2013

  ABSTRACT: Seven rSNPs (rs10157763, rs10927067, rs12031994, rs2125230, rs2345994, rs4132509 and rs4590646) in intron one of thev-akt murine thymoma viral oncogene homolog 3 (AKT3) gene have been significantly associated with either Chronic Mountain Sickness, Renal Cell Carcinoma risk or Aggressive Prostate Cancer. These rSNP alleles alter the DNA landscape for potential transcriptional factors (TFs)to attach, resulting in changes in transcriptional factor binding sites (TFBS). The alleles of each rSNP were found to produce unique TFBS resulting in potential changes in TF AKT3 regulation. These regulatory changes are discussed with respect to the three diseases.