TITLE:
Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents
AUTHORS:
Chunxia Chen, Minghui Lu, Zhihui Liu, Junting Wan, Zhengchao Tu, Tianyu Zhang, Ming Yan
KEYWORDS:
2-Amino-4H-Pyran-3-Carbonitrile; Synthesis; Antitubercular Activity
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.3 No.4,
December
5,
2013
ABSTRACT: A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities
were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious
antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported
data.