Tubercular Uveitis in the Event of HIV Infection about a Case

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. This disease is the second leading cause of infectious mortality in the world after infection with the human immunodeficiency virus. We report a case of multifocal tuberculosis with neuromuscular and ocular localization in an HIV-1 immunosuppressed patient in clinical and virological failure following therapeutic discontinuation due to non-compliance. This is a 43-year-old immunocompromised HIV1 patient with a history of cerebral toxoplasmosis in 2016 who consulted for right hemiplegia. These symptoms would go back to about 3 days marked by a deficit of progressive installation of the right hemicorps preceded by diffuse headaches, of moderate intensity without triggering factor radiating to the eyes associated with an intermittent fever with periods of spontaneous remissions, night sweats and chills, non-selective anorexia, non-increasing physical asthenia and unquantified weight loss. Management was 8-month antituberculous treatment, combining the first two months isoniazid (INH), rifampicin (RMP), pyrazinamide (PZN) and ethambutol (EMB), then the next 6 months (INH) and rifampicin (RMP). The reintroduction of the same antiretroviral protocol and a reinforcement of the therapeutic education made it possible to observe a decrease of the viral load. Treatment of ocular involvement was instituted with Timosol 1 drop in the eyes morning and evening and Diclocid 1 mg/ml: 1 drop in the eyes in the morning.


Introduction
Tuberculosis is an infectious disease caused by a mycobacterium of the Mycobacterium tuberculosis complex. This disease is the second leading cause of infectious mortality in the world after infection with the human immunodeficiency virus [1].
Ocular tuberculosis (TB) is responsible for 5% to 10% of cases of ocular inflammation (OI) [2]. Mycobacterium tuberculosis (MT) can affect all structures of the eye without any pathognomonic presentation. Tuberculous uveitis is the most common lesion [2].
Tuberculosis is in most cases multivisceral. Ocular involvement is present in two-thirds of cases [3] [4].
The number of blindness and other eye diseases associated with acquired immunodeficiency syndrome (AIDS) increases as the disease spreads [4] [5]. In France, the prevalence of ocular involvement during HIV is 67% [6]; in the United States 60% [7].
In Mali, TOGO.R in 2013 [10] found eye damage in the course of HIV in 87.3%.
The clinical manifestations of this infection are polymorphic and variable which makes diagnosis difficult.

Method
This was a case study that allowed us to make a clinical observation on a tuberculous uveitis in an HIV-immunocompromised patient.
OBSERVATION: We report the case of Mr. KC, 43 years old, military who consults for right hemiplegia.
These symptoms would go back to about 3 days marked by a deficit of progressive installation of the right hemicorps preceded by diffuse headaches, of moderate intensity without triggering factor radiating to the eyes associated with an intermittent fever with periods of spontaneous remissions, night sweats and chills, non-selective anorexia, non-increasing physical asthenia and unquantified weight loss.
The physical examination found a Glasgow at 12/15, a disorientation in time and space, a deficit of the right proportional hemi-body, meningeal stiffness, a tonic-clonic crisis without notion of bite of the tongue. The central blood glucose was 4.17 mmol/l.
Since there was no symptomatology made of cough, the search for pulmonary tuberculosis was carried out; a chest x-ray is normal, the search for acid-fast bacilli is negative; intradermal reaction to tuberculin at 6 mm The level of CD4 T lymphocytes was not made because of its unavailability, but the viral load on admission was 526,000 copies/ml. Blood count number found a hemoglobin level of 9.2 g/dl, a hematocrit of 27.6%, white blood cell at 2900/mm 3 , red blood cell at 3,900,000/mm 3 , the red blood cell volume at 89 fl, Plaquette à 188,000/mm 3 , the corpuscular concentration at 33.3 g/dl, lymphocytes at 1720/mm 3 , polynuclear neutrophils at 710/mm 3 , polynuclear basophils at 70 mm 3 , monocytes at 340 mm 3 , lymphocytes at 1720/mm 3 . In front of normochromic normochromic anemia we asked the reticulocytes which come back to 35,400/mm 3 .
The ophthalmological consultation associated with an eye fund was requested; after this consultation the ophthalmologist to suggest to send the patient to retinophoto which objectifies posterior uveitis (Figure 2).
We have been diagnosed with multifocal tuberculosis with neuromuscular and  After the treatment the follow-up at one month shows a viral load at 24,000 copies to become undetectable at 6 mos of treatment. At the end of the anti-tuberculosis treatment the patient was declared cured.

Discussion
On the etiopathogenic level, ocular involvement is mainly due to reactivation of Mycobacterium tuberculosis (MT) favored by an alteration of the immune system (immunosenescence, chronic renal failure, immunosuppressive and anti-TNF treatments). Choroidal inflammation is caused by a cross-hypersensitivity reaction of the immune system to antigens of the choroidal or retinal pigment epithelium [2] [11]. The infection is mostly pauci-bacillary with a low yield of bac- We have described the case of a patient diagnosed with tuberculous uveitis during neuromenic tuberculosis/HIV1, a treatment failure. Tuberculous uveitis is the most frequent ocular lesion [2]. TB is the leading cause of OI of infectious origin in developing countries (60% of infectious uveitis and 5% of all OIEs) [12]. The ULISSE study, which recently compared a standardized strategy to a free strategy for the etiological diagnosis of uveitis, shows that tuberculosis is responsible for 10.7% of the identified cause uveitis among the 676 patients included [13]. The prevalence of ocular TB is greater in immunocompromised patients [14] and asymptomatic ocular involvement is not uncommon in these subjects, justifying systematic ocular exploration [15]. This diagnosis was retained on the basis of clinical and paraclinical arguments.

Conclusion
Ocular involvement is a rare localization of tuberculosis, multidisciplinary management with ophthalmologists allowed us to diagnose this localization in this specific case.