Left Ventricular Dysfunction: The Perspective of Echocardiography in Ghana

Introduction: Ghana is one of the fastest growing economies in sub-Saharan Africa which is expected to undergo a significant epidemiologic transition because of industrialisation and economic development. Having transitioned from low to middle income status recently, this study investigated the epidemiology of left ventricular dysfunction (LVD) in patients who were referred for echocardiography. Material and Methods: We conducted a retrospective cross-sectional study on an out-patient population who were referred to the Precise Specialist Clinic in Kumasi, Ghana for echocardiography, from January 2016 to December 2018. Descriptive statistical analyses were performed and the results summarised in the proportions, tables and pie charts. Categorical variables and proportions were compared using Fisher’s exact test and test of proportions respectively. P-value < 0.05 was considered to be statistically significant. Results: The results show that 61% of the out-patient population referred for echocardiography between 2016 and 2018 had LVD at a mean age of 59 years. In this LVD population, Heart Failure with preserved ejection fraction (HFpEF) and Heart Failure with reduced ejection fraction (HFrEF) accounted for 73% and 27% respectively. The majority of patients with HFrEF also had left ventricular diastolic dysfunction, mitral regurgitation and tricuspid regurgitation. Conclusion: This study shows that, HFpEF was seen in over 70% of patients with LVD, and it occurred at a relatively younger age. Efforts should be made for prevention, early detection and control of conditions such as hypertension, diabetes and obesity which have been shown to be associated with HFpEF.


Introduction
Heart failure is a global health problem affecting over 26 million people worldwide, with sub-Saharan Africa (SSA) having the highest mortality rate of 34% [1]. Over the past decades, heart failure in SSA followed a unique trend, frequently associated with left ventricular systolic dysfunction (LVSD), with the commonest underlying conditions being hypertension, rheumatic heart disease, and cardiomyopathy [2] [3] [4]. However, heart failure in SSA is expected to undergo a significant epidemiologic transition by 2030, because of industrialisation and economic development [5]. The projected change in epidemiologic transition would reflect the increasing life expectancy and the adoption of detrimental lifestyles which were previously alien to SSA [6] [7].
In relation to the epidemiologic transition, recent data suggest that heart failure with preserved ejection fraction is becoming more common in SSA like the developed world [6] [8] [9]. Heart failure with preserved ejection fraction (HFpEF) refers to left ventricular diastolic dysfunction (LVDD) in a heart failure patient who maintains a normal left ventricular ejection fraction (LVEF) of >50%.
While heart failure with reduced ejection (HFrEF) is widely known to be related to LVSD and has well documented treatment options, the management of HFpEF is non-specific and dependent on the underlying condition [10]. Recent studies have confirmed that comorbidities associated with HFpEF include chronic hypertension, obesity and diabetes which are on the rise in SSA and poorly managed in many patients [11] [12]. The rising prevalence of HFpEF may therefore reflect how well underlying comorbidities are being managed in SSA. However, knowledge on the characteristics of HFpEF versus HFrEF in middle-income and low-income countries remain scanty [13]. Given the persistently high mortality rate from heart failure in SSA [1] [14], adequate knowledge on the current epidemiology of left ventricular dysfunction (LVD), including the prevalence of HFpEF and HFrEF, can be helpful to targeting prevention and intervention strategies that could minimize mortality rate.
Transthoracic echocardiography is a good investigation tool for assessing HFpEF and HFrEF which was rarely used in SSA for the investigation and diagnosis of heart failure until recently. In particular, the diagnosis of HFpEF has so many confounders and requires a much more objective method [11]. Existing data on the prevalence of heart failure in most SSA countries were reported before Tissue Doppler Imaging (TDI) became common. As a result, the prevalence of HFpEF and HFrEF were either not reported, or determination of HFpEF was based on only pulsed wave (PW) Doppler which is limited in terms of differentiating normal diastolic function from pseudo-normalization in individuals who have moderate elevation of filling pressure [15]. The purpose of this study, therefore, was to assess the epidemiology of LVD in Ghana, using current standards of echocardiography. Ghana is one of the fastest growing economies in SSA which recently transitioned from low to middle income country. An evaluation on epidemiologic status of LVD in the out-patient population was therefore necessary.

Methodology
We conducted a retrospective cross-sectional study on an out-patient population who were referred to the Precise Specialist Clinic in Kumasi, Ghana for echocardiography, from January 2016 to December 2018. The study included all patients aged ≥15 years, who were referred for echocardiography.
Kumasi is the second largest city in Ghana with a population of over 4 million. As a cosmopolitan society, it has a wide range of the inhabitants from all walks of life. The echocardiography laboratory of this clinic is opened to referrals from all physicians in public and private practice. It therefore serves as a major referral centre for the northern part of Ghana.
A comprehensive transthoracic echocardiographic examination was performed on all out-patient referrals, using GE Vivid S5 Ultrasound machine equipped with 3 -5 MHz sector transducer. All patients were examined in the left lateral decubitus position. The standard scanning planes for assessing left ventricular (LV) function were obtained, including the parasternal long and short axes views, the apical views and the subcostal view. Three LV short-axis views (basal, middle, and apical) and all standard LV apical views (4-, 2-, 3-chamber views) were acquired. M-mode, 2D, colour Doppler, PW Doppler and TDI were obtained in all patients. Image acquisition was obtained during held end-expiration to minimize cardiac respiratory motion.
Quantitative assessment of left ventricular systolic function was based on the parasternal long axis measurements of the ventricular dimensions, intraventricular septum, and left ventricular posterior wall which were used in calculating the ejection fraction in accordance with the Teichholz's method. Systolic dysfunction was then determined by an ejection fraction of <50%, which was further classified as mildly reduced ejection fraction (i.e. 40% -49%) and significantly reduced ejection fraction (<40%).
Assessment of diastolic function was based on the PW Doppler and TDI which were obtained from the annulus of the mitral valve in the apical 4-chamber view. PW Doppler was used in assessing the mitral valve inflow pattern which obtained the peak of passive filling (E wave) and the peak of active filling (A wave) for the calculation of E/A ratio. Deceleration time (DT) of the E wave was also measured along with the isovolumic relaxation time. TDI was performed in the apical views to obtain mitral annular velocities for the E/e' ratio calculation. Diastolic dysfunction was determined by an E/A ratio of <1 or >2, and E/e' ratio of >9.
Colour Doppler was also used in assessing the mitral and tricuspid valves to

Results
Altogether, 594 individuals were referred for echocardiography from January 2016 and December 2018. Table 1 shows the demographic characteristics of the population. Gender and age were fairly distributed below age 70, with a significant female dominance at age 70 and above. Over 60% (367/594) of the population were above 50 years.  Table 2.
Again, the total population with both LVSD and LVDD was 13.1% (see Figure   1). Hence, the prevalence of HFpEF and HFrEF were 44.8% and 16.5% respectively, which yielded the total of 61.3% prevalence of LVD in the entire echocardiography out-patient population.

Discussion
The purpose of this study was to investigate the epidemiology of LVD in patients who were referred for echocardiography in an out-patient setting in Ghana. The results show that 61% of the outpatient population referred for echocardiography between 2016 and 2018 had LVD at a mean age of 59 years. In this LVD population, HFpEF and HFrEF accounted for 73% and 27% respectively. The mean age of patients in this study is consistent with the mean age of heart failure reported by previous studies in Ghana [4] [9] [14]. Amoah and Kallen [16], reported a lower mean age of 42 years in Accra, Ghana because their study included both children and adults. Various studies in the SSA have reported mean age of heart failure between 50 -60 years [17]- [23]. This shows that heart failure is seen about two decades earlier in SSA populations than in the developed countries [24].
This study has also shown that over 70% of LVD in the out-patient population in Ghana is due to HFpEF. This is higher than the findings of Bonsu et al. [14]  and Abebe et al. [8] who reported <60% HFpEF in hospitalized patients in Ghana and Ethiopia respectively. However, it is also evident that their patients were not evaluated with TDI in the assessment of HFpEF; and as a result, patients with pseudo-normalization were not detected [15]. The over 70% HFpEF in this population is the highest being reported by a study from SSA. It however agrees with Martínez-Braña et al. [25] and Kaneko et al. [26] who obtained similar percentages in Spain and Japan respectively, even though their HFpEF population were far older patients than the population in Ghana. It suggests that HFpEF occurs in SSA patients at a younger age than patients in the developed world where HFpEF is associated with older patients who are mostly women and living with chronic hypertension, diabetes or obesity [11]. In this Ghanaian study, the HFpEF population was rather younger, averagely less than 60 years old, and far below the mean age of 80 years reported by Martínez-Braña et al. [25] in Spain.
However, it is known that blacks have a substantially higher risk for hypertension at a younger age than whites [27] which suggests that HFpEF in blacks may also be occurring at a younger age. Moreover, research has shown that although the prevalence of hypertension is declining in developed countries, the trend in SSA is rather on the rise [28] and poorly controlled, with several cases of hypertension undetected [29]. The increasing burden of hypertension obviously makes inhabitants of this region susceptible to HFpEF. Efforts should be made for prevention, early detection and control of hypertension, diabetes and obesity which have been shown to be associated with HFpEF [11].
On the other hand, HFrEF in this population was less than a third of LVD cases. This is lower than previous reports by Owusu et al. [9] and Bonsu et al. [14] in Kumasi, Ghana. Patients with HFrEF tend to have severe symptoms, more likely to be hospitalized; and less likely to be seen in out-patient settings than patients with HFpEF. This might explain the lower prevalence rate of HFrEF seen in this study. Another noteworthy finding of the present study is that 79% of patients with HFrEF also had MR, a condition which is associated with poor long-term survival rate [30]. In addition, there was high percentage of left ventricular and left atrial dilation in relation to HFrEF in this population (see Table 2), which are usually associated with functional MR. Functional MR often develops in patients with severe systolic dysfunction [31] and that the high percentage of such cases in this population suggests that patients with HFrEF do not report early for treatment until the condition gets worse, leading to the higher likelihood of hospitalization with associated increased mortality rate [1]. The limitations of this study are that there were no provisions to follow-up on the outcome of these cases, as most of them were only referred for echocardiography.

Conclusion
In conclusion, HFpEF was seen in over 70% of patients with LVD in this study, and it occurred at a relatively younger age than those seen in developed countries. Efforts should be made for prevention, early detection and control of con-World Journal of Cardiovascular Diseases ditions such as hypertension, diabetes and obesity which have been shown to be associated with HFpEF. Early diagnosis and management of heart failure should therefore be promoted to minimize hospitalization and improve survival of patients with heart failure.