Efficacy of Infliximab Therapy for a Patient with Superficial Thrombophlebitis and Rheumatoid Arthritis


Superficial thrombophlebitis is known as a frequent complication of Behçet’s disease. Infliximab may promote healing of superficial thrombophlebitis in patients with Behçet’s disease. However, thrombophlebitis as a complication of rheumatoid arthritis (RA) is rare and treatments have not been reported. We describe the case of a 47-year-old man with RA with complications of superficial thrombophlebitis who was treated using methotrexate and infliximab. Erythema nodosum and cord-like induration with pain in the extremities completely disappeared following a single infusion of infliximab and oral acetylsalicylic acid was not needed. This case suggests that infliximab might offer effective treatment for patients showing superficial thrombophlebitis with RA.

Share and Cite:

M. Tada, K. Fukai, T. Okano, Y. Sugioka, S. Wakitani, H. Nakamura and T. Koike, "Efficacy of Infliximab Therapy for a Patient with Superficial Thrombophlebitis and Rheumatoid Arthritis," International Journal of Clinical Medicine, Vol. 2 No. 4, 2011, pp. 459-462. doi: 10.4236/ijcm.2011.24077.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] L. Leon, A. D. Giannoukas, D. Dodd, P. Chan and N. Labropoulos, “Clinical Significance of Superficial Vein Thrombosis,” European Journal of Vascular and Endovascular Surgery, Vol. 29, No. 1, 2005, pp. 10-17. doi:10.1016/j.ejvs.2004.09.021
[2] M. Accorinti, M. P. Pirraglia, M. P. Paroli, R. Priori, F. Conti and P. Pivetti-Pezzi, “Infliximab Treatment for Ocular and Extraocular Manifestations of Behcet’s Disease,” Japanese Journal of Ophthalmology , Vol. 51, No. 3, 2007, pp. 191-196. doi:10.1007/s10384-006-0425-y
[3] L. Niccoli, C. Nannini, M. Benucci, D. Chindamo, E. Cassara, C. Salvarani, L. Cimino, G. Gini, I. Lenzetti and F. Cantini, “Long-Term Efficacy of Infliximab in Refractory Posterior Uveitis of Behcet’s Disease: A 24-Month Follow-up Study,” Rheumatology (Oxford), Vol. 46, No. 7, 2007, pp. 1161-1164. doi:10.1093/rheumatology/kem101
[4] S. Ohno, S. Nakamura, S. Hori, M. Shimakawa, H. Kawashima, M. Mochizuki, S. Sugita, S. Ueno, K. Yoshizaki and G. Inaba, “Efficacy, Safety, and Pharmacokinetics of Multiple Administration of Infliximab in Behcet’s Disease with refractory Uveoretinitis,” The Journal of Rheumatology, Vol. 31, No. 7, 2004, pp. 1362-1368.
[5] K. F. Tabbara and A. I. Al-Hemidan, “Infliximab Effects Compared to Conventional Therapy in the Management of Retinal Vasculitis in Behcet Disease,” American Journal of Ophthalmology, Vol. 146, No. 6, 2008, pp. 845- 850.
[6] P. E. Lipsky, D. M. van der Heijde, E. W. St Clair, D. E. Furst, F. C. Breedveld, J. R. Kalden, J. S. Smolen, M. Weisman, P. Emery, M. Feldmann, G. R. Harriman and R. N. Maini, “Infliximab and Methotrexate in the treatment of Rheumatoid Arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group,” The New England Journal of Medicine, Vol. 343, No. 22, 2000, pp. 1594-1602. doi:10.1056/NEJM200011303432202
[7] G. Haugeberg, M. Velken and V. Johnsen, “Successful Treatment of Genital Ulcers with Infliximab in Behcet’s Disease,” Annals of the Rheumatic Diseases, Vol. 63, No. 6, 2004, pp. 744- 745. doi:10.1136/ard.2003.010975
[8] M. Naganuma, A. Sakuraba, T. Hisamatsu, H. Ochiai, H. Hasegawa, H. Ogata, Y. Iwao and T. Hibi, “Efficacy of Infliximab for Induction and Maintenance of Remission in Intestinal Behcet’s Disease,” Inflammatory Bowel Diseases, Vol. 14, No. 9, 2008, pp. 1259-1264. doi:10.1002/ibd.20457
[9] N. Pipitone, I. Olivieri, A. Padula, S. D’Angelo, A. Nigro, G. Zuccoli, L. Boiardi and C. Salvarani, “Infliximab for the Treatment of Neuro-Behcet’s Disease: A Case Series and Review of the Literature,” Arthritis & Rheumatism, Vol. 59, No. 2, 2008, pp. 285-290. doi:10.1002/art.23345
[10] S. P. Travis, M. Czajkowski, D. P. McGovern, R. G. Watson and A. L. Bell, “Treatment of Intestinal Behcet’s Syndrome with Chimeric Tumour Necrosis Factor Alpha Antibody,” Gut, Vol. 49, No. 5, 2001, pp. 725-728. doi:10.1136/gut.49.5.725
[11] J. T. Lee and M. A. Kalani, “Treating Superficial Venous Thrombophlebitis,” Journal of the National Comprehensive Cancer Network, Vol. 6, No. 8, 2008, pp. 760-765.
[12] M. Melikoglu, I. Fresko, C. Mat, Y. Ozyazgan, F. Gogus, S. Yurdakul, V. Hamuryudan and H. Yazici, “Short-Term Trial of Etanercept in Behcet’s Disease: A Double Blind, Placebo Controlled Study,” The Journal of Rheumatology, Vol. 32, No. 1, 2005, pp. 98-105.
[13] P. P. Sfikakis, P. H. Kaklamanis, A. Elezoglou, N. Katsilambros, P. G. Theodossiadis, S. Papaefthimiou and N. Markomichelakis, “Infliximab for Recurrent, Sight- Threatening Ocular Inflammation in Adamantiades- Behcet Disease,” Annals of Internal Medicine, Vol. 140, No. 5, 2004, pp. 404-406.
[14] I. Tugal-Tutkun, A. Mudun, M. Urgancioglu, S. Kamali, E. Kasapoglu, M. Inanc and A. Gul, “Efficacy of Infliximab in the Treatment of Uveitis that is Resistant to Treatment with the Combination of Azathioprine, Cyclosporine, and Corticosteroids in Behcet’s Disease: An Open-Label Trial,” Arthritis & Rheumatism, Vol. 52, No. 8, 2005, pp. 2478- 2484. doi:10.1002/art.21231

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.