The relation between estimated glomerular filtration rate (eGFR) and coffee consumption in the Japanese
Nobuyuki Miyatake, Kenichi Shikata, Hirofumi Makino, Takeyuki Numata
DOI: 10.4236/health.2011.39093   PDF    HTML     4,391 Downloads   8,423 Views   Citations


We investigated the link between estimated glomerular filtration rate (eGFR) and coffee consumption in Japanese. We used data of 376 men and 794 women who were not taking any medications, aged 20 - 78 years, in this cross- sectional investigation study. eGFR was calcu-lated using serum creatinine (Cr), age and sex. Habitual coffee consumption was defined as drinking one or more cups of coffee per day. Two hundred thirty three men (62.0%) and 400 women (50.4%) were subjects with habitual coffee consumption (coffee consumption 1 cup/ day ≥). eGFR was negatively correlated with age (men: r = –0.533, women: r = –624). eGFR in subjects with coffee consumers was not significantly different from that in subjects without coffee consumers after adjusting for age in both sexes (men: p = 0.1375, women: p = 0.2069). Among Japanese not taking medications, coffee consumption was not associated with eGFR in the Japanese population.

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Miyatake, N. , Shikata, K. , Makino, H. and Numata, T. (2011) The relation between estimated glomerular filtration rate (eGFR) and coffee consumption in the Japanese. Health, 3, 549-552. doi: 10.4236/health.2011.39093.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] All Japan Coffee Association (2011).
[2] Iso, H., Date, C., Wakai, K., Fukui, M., Tamakoshi, A., JACC Study Group. (2006) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Annals of Internal Medicine, 144, 554-562.
[3] Van Dam, R.M. (2008) Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Applied Physiology, Nutrition, and Metabolism, 33, 1269-1283. doi:10.1139/H08-120
[4] Greenberg, J.A., Boozer, C.N. and Geliebter, A. (2006) Coffee, diabetes, and weight control. The American Journal of Clinical Nutrition, 84, 682-693.
[5] Tunnicliffe, J.M. and Shearer, J. (2008) Coffee, glucose homeostasis, and insulin resistance: Physiological mechanisms and mediators. Applied Physiology, Nutrition, and Metabolism, 33, 1290-1300. doi:10.1139/H08-123
[6] Tofovic, S.P. and Jackson, E.K. (1999) Effects of long-term caffeine consumption on renal function in spontaneously hypertensive heart failure prone rats. Journal of Cardiovascular Pharmacology, 33, 360-366. doi:10.1097/00005344-199903000-00003
[7] National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Kidney Disease Outcome Quality Initiative. American Journal of Kidney Diseases, 39, S1-S266.
[8] Imai, E., Horio, M., Iseki, K., Yamagata, K., Watanabe, T., Hara, S., Ura, N., Kiyohara, Y., Hirakata, H., Moriyama, T., Ando, Y., Nitta, K., Inaguma, D., Narita, I., Iso, H., Wakai, K., Yasuda, Y., Tsukamoto, Y., Ito, S., Makino, H., Hishida, A. and Matsuo, S. (2007) Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clinical and Experimental Nephrology, 11, 156-163. doi:10.1007/s10157-007-0463-x
[9] Matsuo, S., Imai, E., Horio, M., Yasuda, Y., Tomita, K., Nitta, K., Yamagata, K., Tomino, Y., Yokoyama, H. and Hishida, A. (2009) Revised equations for estimated GFR from serum creatinine in Japan. American Journal of Kidney Diseases, 53, 982-992. doi:10.1053/j.ajkd.2008.12.034
[10] Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2010) Relationship between Estimated Glomerular Filtration Rate (eGFR) and Metabolic Syndrome in the Japanese Population. Acta Medica Okayama, 64, 203-208.
[11] Anonym (2005) Definition and the diagnostic standard for metabolic syndrome—Committee to Evaluate Diagnostic Standards for Metabolic Syndrome. Nippon Naika Gakkai Zasshi, 94, 794-809. doi:10.2169/naika.94.794
[12] Nakajima, K., Hirose, K., Ebata, M., Morita, K. and Munakata, H. (2009) Association between habitual coffee consumption and normal or increased estimated glomerular filtration rate in apparently healthy adults. British Journal of Nutrition, 103, 149-152. doi:10.1017/S0007114509991681
[13] Kotani, K., Sakane, N., Yamada, T. and Taniguchi, N. (2010) Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: Preliminary data regarding C-reactive protein concentration. Clinical Chemistry and Laboratory Medicine, 48, 1773-1776. doi:10.1515/CCLM.2010.347

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