HLA allele frequencies in Iranian opticospinal multiple sclerosis patients
——HLA in Opticospinal MS


Background: In Iranian patients with opticospinal multiple sclerosis (OSMS), a paucity of brain lesions and short spinal cord lesions extending less than three spinal segments are characteristic findings on magnetic resonance imaging (MRI). It also shows a relatively benign course with negative CSF oligo-coonal bands. Objective: We aimed to clarify the possible relationship between clinical phenotype and MRI features of OSMS and human leucocyte antigen (HLA) system in Iran. Methods: Genotyping of HLA class II allele frequencies in 20 patients with OSMS were done, using polymerase chain reaction sequence-specific primer amplification method. Blood samples were extracted and typed for HLA-DRB, DQA, and DQB loci and compared with 100 controls. Results: Significant positive association was observed in DRB1*03, DQA1*0201, DQA1*03, DQB1*0201, and DQB1*0611, while DQB1*0602 was absent in our patients. Conclusion: These finding suggest that HLA-DRB association pattern in OSMS is different from conventional MS in Iran which is mostly associated with DRB1*1501 and from similar Japanese OSMS who are negative for brain lesions fulfilling the Barkhof criteria and negative for the presence of longitudinally extensive spinal cord lesions who carries the DRB*0405 allele. OSMS is immunogenetically heterogeneous. Also absence of DQB1*0602 allele may negatively be associated with the absence of Barkhof brain lesion.

Share and Cite:

Kalanie, H. , Kamgooyan, M. , Kholghie, Y. , Harandi, A. and Hosseinzadeh, Z. (2011) HLA allele frequencies in Iranian opticospinal multiple sclerosis patients
——HLA in Opticospinal MS. Journal of Biomedical Science and Engineering, 4, 511-515. doi: 10.4236/jbise.2011.47065.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hafler, D.A. (2004) Multiple sclerosis. Journal of Clinical Investigation, 113, 788-794.
[2] Barnett, M.H. and Prineas, J.W. (2004) Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Annals of Neurology, 55, 458-468. doi:10.1002/ana.20016
[3] Kornek, B. and Lassmann, H. (2003) Neuropathology of multiple sclerosis-new concepts. Brain Research Bulletin, 61, 321-326. doi:10.1016/S0361-9230(03)00095-9
[4] Hogancamp, W.E., Rodriguez, M. and Weinshenker, B.G. (1997) The epidemiology of multiple sclerosis. Mayo Clinic Proceedings, 72, 871-878. doi:10.4065/72.9.871
[5] Olerup, O. and Hillert, J. (1991) HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation. Tissue Antigens, 38, 1-15. doi:10.1111/j.1399-0039.1991.tb02029.x
[6] Akesson, E., Oturai, A., Berg, J., Fredrikson, S., Andersen, O., Harbo, H.F., Laaksonen, M., Myhr, K.M., Nyland, H.I., Ryder, L.P., Sandberg-Wollheim, M., Sorensen, P.S., Spurkland, A., Svejgaard, A., Holmans, P., Compston, A., Hillert, J. and Sawcer, S. (2002) A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes Immunity, 3, 279-285. doi:10.1038/sj.gene.6363866
[7] Wasay, M., Khatri, I.A., Khealani, B. and Sheerani, M. (2006) MS in Asian countries. International MS Journal, 13, 58-65.
[8] Kira, J., Yamasaki, K., Horiuchi, I., Ohyagi, Y., Taniwaki, T. and Kawano, Y. (1999) Changes in the clinical phenotypes of multiple sclerosis during the past 50 years in Japan. Journal of the Neurological Sciences, 166, 53-57. doi:10.1016/S0022-510X(99)00115-X
[9] Kira, J., Kanai, T., Nishimura, Y., Yamasaki, K., Matsushita, S., Kawano, Y., Hasuo, K., Tobimatsu, S. and Kobayashi, T. (1996) Western versus Asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders. Annals of Neurology, 40, 569-574. doi:10.1002/ana.410400405
[10] Fukazawa, T., Kikuchi, S., Miyagishi, R., Miyazaki, Y., Yabe, I., Hamada, T. and Sasaki, H. (2006) HLA- dPB1*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1*0301. Multiple Sclerosis, 12, 19-23. doi:10.1191/135248506ms1252oa
[11] Matsuoka, T., Matsushita, T., Osoegawa, M., Ochi, H., Kawano, Y., Mihara, F., Ohyagi, Y. and Kira, J. (2008) Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings. Journal of the Neurological Sciences, 266, 115-125. doi:10.1016/j.jns.2007.09.010
[12] Kalanie, H., Kholghie, Y., Shamsai, G.R. and Ghorbani, M. (2009) Opticospinal multiple sclerosis in Iran. Journal of the Neurological Sciences, 276, 130-132. doi:10.1016/j.jns.2008.09.038
[13] Kuroiwa, Y., Igata, A., Itahara, K., Koshijima, S. and Tsubaki, T. (1975) Nationwide survey of multiple sclerosis in Japan. Clinical analysis of 1084 cases. Neurology, 25, 845-851.
[14] Houzen, H., Niino, M., Kikuchi, S., Fukazawa, T., Nogoshi, S., Matsumoto, H. and Tashiro, K. (2003) The prevalence and clinical characteristics of MS in northern Japan. Journal of the Neurological Sciences, 211, 49-53.
[15] Zhao, B. X., Liu, X. Q., Guo, Y. P., Yang, Y. C. and Huang, H. F. (1981) Multiple sclerosis. A clinical study of 70 cases. European Neurology, 20, 394-400.
[16] Hung, T.P., Landsborough, D. and Hsi, M.S. (1976) Multiple sclerosis amongst Chinese in Taiwan. Journal of the Neurological Sciences, 27, 459-484. doi:10.1016/0022-510X(76)90214-8
[17] Das, A. and Puvanendran, K. (1998) A retrospective review of patients with clinically definite multiple sclerosis. Annals, Academy of Medicine, Singapore, 27, 204-209.
[18] Jitpimolmard, S. and Vejjajiva, A. (1994) Clinical features and clinical course of multiple sclerosis in Thai patients: A report of 50 cases. Journal of The Medical Association of Thailand, 77, 239-243.
[19] Kurtzke, J.F., Park, C.S. and Oh, S.J. (1968) Multiple sclerosis in Korea. Clinical features and prevalence. Journal of the Neurological Sciences, 6, 463-481. doi:10.1016/0022-510X(68)90031-2
[20] Tan, C.T. (1998) Multiple sclerosis in Malaysia. Archives of Neurology, 45, 624-627.
[21] Kalanie, H., Gharagozli, K. and Kalanie, A.R. (2003) Multiple sclerosis: Report on 200 cases from Iran. Multiple Sclerosis, 9, 36-38. doi:10.1191/1352458503ms887oa
[22] Kalanie, H., Kamgooyan, M., Sadeghian, H. and Kalanie A.R. (2000) Histocompatibility antigen (HLA) associations with multiple sclerosis in Iran. Multiple Sclerosis, 6, 317-319.
[23] Massey, H.D. and McPherson, R.A. (2007) The major histocompatibility complex of man. In: McPherson R.A. and Pincus M.R. Eds., Henry’s clinical diagnosis and management by laboratory methods. 21st Edition, Saunders Elsevier, Beijing, 876-893.
[24] Julio, C.D. and Edmond, J.Y. (2007) The Major Histocompatibility Complex and Disease. In Henry’s Clinical Diagnosis and Management by Laboratory Methods, Saunders-Elsevier, 21st Edition, 8, 894-902.
[25] Misu, T., Fujihara, K., Nakashima, I., Miyazawa, I., Okita, N., Takase, S. and Itoyama, Y. (2002) Pure optic-spinal form of multiple sclerosis in Japan. Brain, 125, 2460-2468. doi:10.1093/brain/awf260
[26] Nakashima, I., Fukazawa, T., Ota, K., Nohara, C., Warabi, Y., Ohashi, T., Miyazawa, I., Fujihara, K. and Itoyama, Y. (2007) Two subtypes of optic-spinal form of multiple sclerosis in Japan: Clinical and laboratory features. Journal of Neurology, 254, 488-492. doi:10.1007/s00415-006-0400-z
[27] Matsuoka, T., Matsushita, T., Osoegawa, M., Kawano, Y., Minohara, M., Mihara, F., Nishimura, Y., Ohyagi, Y. and Kira, J. (2008) Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. Multiple Sclerosis, 14, 1181-1190. doi:10.1177/1352458508097818
[28] Brum, D.G., Barreira, A.A., Santos dos, A.C., Kaimen-Maciel, D.R., Matiello, M., Costa, R.M., Deghaide, N.H., Costa, L.S., Louzada-Junior, P., Diniz, P.R., Comini-Frota, E.R., Mendes-Junior, C.T. and Donadi, E.A. (2010) HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis. Multiple Sclerosis, 16, 21-29. doi:10.1177/1352458509350741
[29] Weinshenker, B.G. and Wingerchuk, D.M. Neuromyelitis optica: Clinical syndrome and the NMO-IgG autoantibody marker. Current Topics in Microbiology and Immunology, 318, 343-356. doi:10.1007/978-3-540-73677-6_14
[30] Kira, J. (2008) Neuromyelitis optica and Asian phenotype of multiple sclerosis. Annals of the New York Academy of Sciences, 1142, 58-71. doi:10.1196/annals.1444.002
[31] Nandhagopal, R., Al-Asmi, A. and Gujjar, A.R. (2010) Neuromyelitis optica: An overview. Postgraduate Medical Journal, 86, 153-159. doi:10.1136/pgmj.2009.091389

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.