The Clinical Association of Autosomal Dominant Polycystic Kidney Disease and renal cell Carcinoma
Wesley Lane, Evan Lacefield, Ruc Tran, Werner de Riese
DOI: 10.4236/oju.2011.12004   PDF    HTML     6,895 Downloads   15,170 Views   Citations


Autosomal Dominant Polycystic Kidney Disease (ADPKD) is not currently considered to be a risk factor for renal cell carcinoma (RCC). We present data from our institution demonstrating incidence of RCC with ADPKD above the incidence rate for RCC in the general population, as well as that in patients with end-stage renal disease (ESRD). The discussion relates our findings in the context of the current literature including recent case reports published in this entity.

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W. Lane, E. Lacefield, R. Tran and W. Riese, "The Clinical Association of Autosomal Dominant Polycystic Kidney Disease and renal cell Carcinoma," Open Journal of Urology, Vol. 1 No. 2, 2011, pp. 11-14. doi: 10.4236/oju.2011.12004.

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The authors declare no conflicts of interest.


[1] W. Walters and W. F. Brasch, “Surgical Aspects of Polycystic Kidney,” Surgical and Gynacological Obstetrics, Vol. 58, No. 3, 1934.
[2] Y. L. Chang, H. J. Chung and K. K. Chen, “Bilateral Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease,” Journal of the Chinese Medical Association, Vol. 70, No.9, 2007, pp. 403-405. doi:10.1016/S1726-4901(08)70029-7
[3] A. A. Borski and J. C. Kimbrough, “Bilateral Renal Cell Carcinoma in Polycystic Kidney Disease, an Unique Case,” Journal of Urology, Vol. 71 No. 5, 1954, pp. 677- 681.
[4] J. R. Gregoire, V. E. Torres, K. E. Holley and G. M. Farrow, “Renal Epithelial Hyperplastic and Neoplastic Proliferation in Autosomal Dominant Polycystic Kidney Disease,” American Journal of Kidney Diseases, Vol. 9 No. 1, 1987, pp. 27-38.
[5] D. S. Keith, V. E. Torres, B. F. King, H. Zincki and G. M. Farrow, “Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease,” Journal of the American Society of Nephrology, Vol. 4, No. 9, 1994, pp. 1661-1669.
[6] P. Hajj, et al., “Prevalence of Renal Cell Carcinoma in Patients with Autosomal Dominant Polycystic Kidney Disease and Chronic Renal Failure,” Urology, Vol. 74, No. 3, 2009, pp. 631-634. doi:10.1016/j.urology.2009.02.078
[7] A. J. Wein, et al., “Campbell-Walsh Urology,” 9th Edition, Elsevier Inc., Philidelphia, Vol. 2, pp. 1583-1588 and Vol.4, 2007, pp. 3323.
[8] L. Gomella, “The 5-Minute Urology Consult,” Lippincott Williams and Wilkins, Philidelphia, PA, 2009.
[9] K. L. Wang, et al., “Renal Papillary Adenoma-A Putative Precursor of Papillary Renal Cell Carcinoma,” Human Pathology, Vol. 38, No. 2, 2007, pp. 239-246. doi:10.1016/j.humpath.2006.07.016
[10] D. K. Espey, et al., “Annual Report to the Nation on the Status of Cancer, 1975-2004, Featuring Cancer in American Indians and Alaskan Natives,” Cancer, Vol. 110, No. 10, 2007, pp. 2119-2152. doi:10.1002/cncr.23044
[11] B. I. Rini, S. C. Campbell and B. Escudier “Renal Cell Carcinoma,” Lancet, Vol. 28, No. 373, 2009, pp. 1119-1132. doi:10.1016/S0140-6736(09)60229-4
[12] R. P. Theis, S. M. Dolwick Grieb, D. Blurr, T. Siddiqui and N. R. Asal “Smoking, Environmental Tobacco Smoke, and Risk of Renal Cell Cancer: A Population-Based Case-Control Study,” BMC Cancer, Vol. 8, No. 387, 2008, pp. 1-11.
[13] Y. Wang, X. Chen, Y. Song, B. Caballero and L. J. Cheskin, “Association between Obesity and Kidney Disease: A Systematic Review and Meta-Analysis,” Kidney International, Vol. 73, No. 1, 2008, pp. 19-33. doi:10.1038/
[14] P. A. Gabow, “Autosomal Dominant Polycystic Kidney Disease.” New England Journal of Medicine, Vol. 329, No. 5, 1993, pp. 332-342. doi:10.1056/NEJM199307293290508
[15] K. Badani, A. K. Hemal and M. Menon, “Autosomal Dominant Polycystic Kidney Disease and Pain - A Review of the Disease from Aetiology, Evaluation, Past Surgical Treatment Options to Current Practice,” Journal of Postgraduate medicine, Vol. 50, No. 3, 2004, pp. 222-226.
[16] Y. Kojima, S. Takahara, O. Miyake, N. Nonomura, A. Morimoto and H. Mori, “Renal Cell Carcinoma in Dialysis Patients: A Single Center Experience,” International Journal of Urology, Vol. 13 No. 8, 2006, pp. 1045-1048. doi:10.1111/j.1442-2042.2006.01498.x
[17] H. Nishimura, “Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease,” American Journal of Kidney Disease, Vol. 54, No. 1, 2009, pp. 165-168. doi:10.1053/j.ajkd.2009.01.270
[18] A. Kapoor, et al., “Renal Cell Carcinoma in Autosomal Dominant Polycystic Kidney Disease,” European Journal of Radiology Extra, Vol. 51, No. 2, 2004, pp. 87-89. doi:10.1016/j.ejrex.2004.05.003
[19] I. Ishikawa, et al., “Development of Acquired Cystic Disease and Adenocarcinoma of the Kidney in Glomerulonephrotic Chronic Hemodialysis Patients,” Clinical Nephrolgy, Vol. 14, No. 1, 1980, pp. 1-6.

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