Analysis on the clinical and endoscopic parameters in 1247 patients with reflux esophagitis


Aim: To summarize and analyze the clinical and endoscopic parameters in patients with reflux esophagitis(RE). Methods1247 patients with RE were diagnosed in our hospital endoscopy center from September 2010 to August 2012. The general information of the patients and the relationship between endoscopic classification and concomitant diseases were analyzed. Results: According to the endoscopic findings, 1247 subjects (4.70%) were found to have RE932 (74.74%) males and 315 (25.26%) females, and the male to female ratio was 2.96:1. The peak age of prevalence was 50 to 59 (27.35%) which is followed by 40 to 49 (23.10%). In this study, most of the patients had a mild degree of esophagitis representing LA-A in 60.63% and LA-B in 34.24%. The antrum hyperemia was found in 291 patients with esophagitis (23.34%), followed by antrum erosion (20.13%) and hatal hernia (15.88%). There is no statistically significant relevance between Helicobacter pylori infection and RE (P > 0.05), but Barrett’s esophagus, duodenal ulcer, gastroesophageal tumors, a history of gastroesophageal surgery and antrum hyperemia were found to be associated with RE (P < 0.05). Conclusion: The prevalence rate of endoscopic RE in our study was 4.70%, and most patients had a mild grade esophagitis. Male, advanced age, Barrett’s esophagus, duodenal ulcer, gastroesophageal tumors and a history of gastroesophageal surgery are the risk factors of esophagitis. Antrum hyperemia may reduce the severity of RE.

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Zhang, X. , Wang, H. , Wang, W. , Chen, X. and Liu, H. (2014) Analysis on the clinical and endoscopic parameters in 1247 patients with reflux esophagitis. Open Journal of Gastroenterology, 4, 19-23. doi: 10.4236/ojgas.2014.41004.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Vakil, N., Van Zanten, S.V., Kahrilas, P., et al. (2006) The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus. American Journal of Gastroenterology, 101, 1900-1920.
[2] Jung, H.-K. (2011) Epidemiology of gastroesophageal reflux disease in Asia: A systematic review. Journal of Neurogastroenterology and Motility, 17, 14-27.
[3] Wang, P.-C., Hsu, C.-S., Tseng, T.-C., et al. (2012) Male sex, hiatus hernia, and Helicobacter pylori infection associated with asymptomatic erosive esophagitis. Journal of Gastroenterology and Hepatology, 27, 586-591.
[4] Shim, K.-N., Hong, S.J., Sung, J.K., et al. (2009) Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up: A nationwide multi-center prospective, endoscopy-based study. Journal of Gastroenterology and Hepatology, 43, 632-638.
[5] Kahrilas, P.J. and Boeckxstaens, G. (2012) Failure of reflux inhibitors in clinical trials: Bad drugs or wrong patients? Gut, 61, 1501-1509.
[6] Armstrong, D., Bennett, J.R., Blum, A.L., et al. (1996) The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology, 111, 85-92.
[7] Miwa, H., Yokoyama, T., Hori, K., et al. (2008) Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: A validation study in a cohort of Japanese endoscopists. Diseases of the Esophagus, 21, 355-363.
[8] Chinese Medical Association Society for Gastrointestinal Endoscopy (2000) Diagnosis and treatments of reflux esophagitis disease (inflammation) (Trial). Journal of Internal Medicine, 39, 2101.
[9] Liu, H.F. and Wang, W.A. (2009) Gastroesophageal reflux disease. Beijing Scientific and Technical Documents Publishing House, Beijing, 92-93.
[10] Fass, R. (2012) Therapeutic options for refractory gastroesophageal reflux disease. Journal of Gastroenterology and Hepatology, 27, 3-7.
[11] Zerbib, F. (2010) Medical treatment of GORD. Emerging therapeutic targets and concepts. Best Practice & Research Clinical Gastroenterology, 24, 937-946.
[12] Dent, J., El-Serag, H.B., Wallander, M.A., et al. (2005) Epidemiology of gastro-oesophageal reflux disease: A systematic review. Gut, 54, 710-717.
[13] El-Serag, H.B., Graham, D.Y., Satia, J.A., et al. (2005) Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. American Journal of Gastroenterology, 100, 1243-1250.
[14] Yuksel, E.S. and Vaezi, M.F. (2012) New developments in extraesophageal reflux disease. Gastroenterology & Hepatology, 8, 590-599.
[15] Ronkainen, J., Aro, P., Storskrubb, T., et al. (2005) High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: A Kalixanda study report. Scandinavian Journal of Gastroenterology, 40, 275-285.
[16] Kim, N., Lee, S.W., Cho, S.I., et al. (2008) The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: A nationwide multicentre prospective study in Korea. Alimentary Pharmacology & Therapeutics, 27, 173-185.
[17] Wang, F. and Fan, Y.J. et al. (2007) Clinical analysis of 4311 patients with reflux esophagitis. Zhengzhou University (Medical Sciences), 42, 1114-1116.
[18] Goh, K.-L. (2011) Gastroesophageal reflux disease in Asia: A historical perspective and present challenges. Gastroenterology and Hepatology, 26, 2-10.
[19] Yang, X.M., Shen, H. and Ma, S.H. (2005) Analysis of reflux esophagitis and factors correlated with it on endoscopic examination. China Journal of Endoscopy, 11, 265-267.
[20] Choi, J.Y., Jung, H.-K., Song, E.M., et al. (2013) Determinants of symptoms in gastroesophageal reflux disease: Nonerosive reflux disease, symptomatic, and silent erosive reflux disease. European Journal of Gastroenterology & Hepatology, 25, 764-771.
[21] Miwa, H., Takubo, K., Shimatani, T., et al. (2013) Histology of symptomatic gastroesophageal reflux disease: Is it predictive of response to proton pump inhibitors? Journal of Gastroenterology and Hepatology, 28, 479-487.
[22] Zhu, Z.-J. (2011) Clinical and endoscopic features of 767 cases with reflux esophatitis. China Coal Industry Medicine, 14, 1661-1662.
[23] Becher, A. and Den, J. (2011) Systematic review: Ageing and gastro-oesophageal reflux disease symptoms, oesophageal function and reflux oesophagitis. Aliment Pharmacol Ther, 33, 442-454.
[24] Wang, P.-C., Hsu, C.-S. and Tseng, T.-C. (2012) Male sex, hiatus hernia, and Helicobacter pylori infection associated with asymptomatic erosive esophagitis. Journal of Gastroenterology and Hepatology, 27, 586-591.
[25] Li, W., Jia, F., Zhang, S.-T., et al. (2008) Clinical and endoscopic analysis on cases of reflux esophagitis. Chinese Journal of Internal Medicine, 28, 738-741.

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