Microbial Diversity in Patients with Gastroduodenal Diseases


H. pylori infection is mainly spread in the kind of gastroduodenal diseases: chronic gastritis, peptic ulcer disease, MALT-lymphoma, gastric cancer. According to certain literature, the mentioned bacterium causes diseases of other visceral organs of humans. Study of the aggravating impact of this infection is under the attention of the scientists. However, other infectious agents, including fungi, other bacteria, parasites, and viruses and their role in different gastroduodenal diseases are not studied enough. The aim of our study was to identify mucous (parietal) gastroduodenal microflora in patients with different diseases of this zone. 390 patients with chronic gastritis (CG), peptic ulcer diseases (PUD) and gastric cancer (GC) were included in the study. The resection materials and biopsy specimens were taken during the operation or endoscopy procedures. Identification of strains H. pylori, Candida spp and others was performed by established methods, on the basis of morphological, tinctorial, cultural and biochemical properties. Microflora of patients with different gastroduodenal diseases is diverse enough. It is represented by facultative, obligate anaerobes, microaeropilic bacteria. More frequently, there were H. pylori and Candida sp, as well as in associations and monocultures. The obtained results confirmed the wide distribution of H. pylori and Candida spp and their frequent coexistence in patients with gastric cancer, chronic gastritis and peptic ulcer disease. Microflora of patients with CG and GC was represented on 11 species. Microflora of patients with PUD-13 species was more diverse.

Share and Cite:

S. Khetsuriani and K. Khetsuriani, "Microbial Diversity in Patients with Gastroduodenal Diseases," Advances in Microbiology, Vol. 4 No. 2, 2014, pp. 69-72. doi: 10.4236/aim.2014.42011.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] G. B. Huffnagle and M. G. I. Noverr, “Microbiota and Regulation of the Immune System,” 2008, pp. 16-24.
[2] K. E. L. McColl, “Helicobacter pylori Infection,” NEJM, Vol. 362, No. 17, 2010, pp. 1597-1604.
[3] D. C. Savage, “Microbial Ecology of the Gastrointestinal Tract,” Annual Review of Microbiology, Vol. 31, 1977, pp. 107-139.
[4] A. F. Andersson, M. Undlerg, H. Jakobsson, et al., “Comparative Analysis of Human Gut Microflora by Barcode Pyrosequencing,” PLoS ONE, Vol. 3, 2008, Article ID: e 2836.
[5] E. M. Bik, P. B. ECkburg, et al., “Molecular Analysis of the Bacterial Microbiota in the Human Stomach,” Proceedings of the National Academy of Sciences, Vol. 102, 2006, pp. 732-737.
[6] J. Holton, “Peptic Ulcer Disease 2009, from “Genomic and Personalizes Medicine,” Vol. 1-2, 2nd Edition, pp. 914-935.
[7] J. G. Kusters, A. H. van Vliet and E. J. Kuipers, “Pathogenesis of Helicobacter pylori Infection,” Clinical Microbiology Reviews, Vol. 19, No. 3, 2006, pp. 449-490.
[8] I. M. Toller, et al., “Carcinogenic Bacterial Pathogen Helicobacter pylori Triggers DNA Double-Strand Breaks and a DNA Damage Response in Its Host Cells,” Proceedings of the National Academy of Sciences, Vol. 108, 2011, Article ID: 14944.
[9] E. Karczewska, I. Wojtas, E. Sito, et al., “Asessment of CoExistance of Helicobacter pylori and Candida Fungi in Diseases of the Upper Gastrointestinal Tract,” Journal of Physiology and Pharmacology, No. S6, 2009, pp. 33-39.
[10] V. V. Chernin, V. M. Bondarenko, V. M. Chervinets and S. N. Bazlov, “Dysbacteriosis of Mucosal Microflora of the Gastroduodenal Zone in Inflammatory and Ulcer Lesions: Diagnosis and Classification,” Terapevticheskii arkhiv, Vol. 80, No. 2, 2008, pp. 21-25.
[11] J. G. Holt, “Bergey’s Manual of Determinative Bacteriology,” Williams & Wilkins, Baltimore, 1994.
[12] N. Z. Minaeva, U. M. Nesvizhsky, V. I. Minaev, L. V. Kudriavtseva, S. V. Zaitseva, K. I. Chekalina, B. L. Cherkasskii and P. L. Shcherbakov, “Mikrobiologicheskaia Diagnostika Zabolevanii, Vyzvannykh Mikroaerofil’Nymi Izognutymi Bakteriiami. M., 2001, 42 p.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.