Application of Van der Pol oscillator screening for peripheral arterial disease in patients with diabetes mellitus


This paper proposes a Van der Pol (VDP) oscillator screening for peripheral arterial disease (PAD) in patients with diabetes mellitus. The long-term elevated blood sugar levels produce a high risk of peripheral neuropathy and peripheral vascular disease, especially in the foot of a diabetic. Early detection is important, in order to prevent foot problems for diabetic patients with PAD. Photoplethysmography (PPG) is a non-invasive method for the detection of blood volume changes in peripheral arteries. Because of changes in the resistance-compliance, the rise time and transit time for the PPG signals increase and change in their shape are highly correlated with PAD severity. In this study, the Burg autoregressive (AR) method is used to determine the characteristic frequencies of the right-and left-side PPG signals. For bilateral frequency spectra, the VDP oscillator uses asynchronous signals. This produces damped sinusoidal responses and the oscillation overshoot (OS) is an approximating function only of the damped factor. This index is used to estimate the degree of PAD, including normal the condition and diabetic patients with PAD. The results show that the proposed method is efficient and more accurate in the estimation of PAD.


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Wu, J. , Li, C. , Chen, W. , Lin, C. and Chen, T. (2013) Application of Van der Pol oscillator screening for peripheral arterial disease in patients with diabetes mellitus. Journal of Biomedical Science and Engineering, 6, 1143-1154. doi: 10.4236/jbise.2013.612143.

Conflicts of Interest

The authors declare no conflicts of interest.


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