Serum immunoglobulin E level of children infected with intestinal parasite in Okada, Nigeria


Children especially in rural areas of Okada have high rates of intestinal parasitosis with a prevalence of 50%. Stool and blood sample were collected of 334 children which comprised of 152 females and 185 males. Intestinal parasitosis was confirmed by direct smear technique and formol-ether concentration method. Serum IgE level was estimated by ELISA method. It was revealed that children between the ages of 11 - 15 years had the highest incidence of intestinal parasite in both sex (73.3% of the males and 62.5% of the females). About 2-fold elevation in serum IgE level was demonstrated. Intervention program including early introduction of health education to children is advocated and environmental sanitation should be encouraged.

Share and Cite:

Ehiaghe, A. , Agbonlahor, E. , Ifeanyichukwu, O. , Kester, D. , Ehiaghe, o. and Oviasogie, F. (2013) Serum immunoglobulin E level of children infected with intestinal parasite in Okada, Nigeria. Open Journal of Immunology, 3, 123-126. doi: 10.4236/oji.2013.33017.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Arinola, O.G. and Fawole, O.O. (1995) Prevalence of protozoan and heliminthic infections among different occupational and age group in Iroko Village, Oyo State, Nigeria. Journal of Scientific Engineering Technology, 2, 51-57.
[2] Ramesh, G.N., Malla, N., Raju, G.S., Sehgal, R., Ganguly, N.K., Mahajan, R.C. and Dilawari, J.B. (1991) Epidemiological study of parasitic infestations in lower socioeconomic group in chandigarh (North Indian). Indian Journal of Medical Research, 93, 47-50.
[3] Fabiana, L. and Carolina, M. (2002) Giardiosis in children. BMC Public Health, 2, 5.
[4] World Health Organization (1998) Control of tropical disease. WHO, Geneva.
[5] Evans, A.C. and Stehenson, L.S. (1995) Not by drugs alone: The fight against parasitic helminthus. World Health Forum, 16, 258-261.
[6] Arinola, O.G., Yagub, A. and Rahamon, K.S. (2012) Reduced serum IgE level in Nigerian children with helminthiasis compared with protozoan infection: Implication on hygine hypothesis. Annals of Biological Research, 3, 5754- 5757.
[7] Winter, W.E., Hardt, N.S. and Fuhrman, S. (2000) Immunoglobulin E. Importance in parasite infection and hypersensitively response. Archives of Pathology & Laboratory Medicine, 124, 1382-1385
[8] Arinola, O.G. (2000) Serum total IgE level in healthy children and adults in Ibadan, Nigeria. Tanzania Medical Journal, 23, 9-10.
[9] Pearce, E.J., Kane, M.C. and Sun, J. (2004) Th2 response polarization during infection with the helminth parasite schistosoma mansoni. Immunological Reviews, 201, 117- 126. doi:10.1111/j.0105-2896.2004.00187.x
[10] Naing, L., Winn, T. and Rush, B.N. (2006) Practical issues in calculating the sample size for prevalence studies. Archives of Orofacial Sciences, 1, 9-14.
[11] Markell, K. and Voge, M. (1998) Medical parasitology. 8th Edition, Saunder Company Publication.
[12] Brage, L.L., Lima, A.A., Sears, C.L. and Newman, R.P. (1996) Seroepidemiology of E. hitoliytical in a slum in northern Brazil. The American Journal of Tropical Medicine and Hygiene, 55, 693-697.
[13] Shammari, S.A., Khoja, T., Khwasky, F.E. and Gad, A. (2001) Intestinal parasitic disease in Riyadh, Saudi Arabia. Prevalence, sociodemographic and environmental associates. Tropical Medicine & International Health, 6, 184- 189. doi:10.1046/j.1365-3156.2001.00698.x
[14] Pu, Z. and Francisca, M. (2006) A key antibody in Schistosoma infection. Electronic Journal of Biology, 2, 11-14.
[15] Nagaraji, S., Raghavan, R., Macaden, R. and Kurpad, A.V. (2004) Intestinal parasitic infection and total serum IgE in asymtoatic adult males in an urban slum and efficacy of antiparasitic therapy. Indian Journal of Medical Microbiology, 22, 56-56.
[16] Koski, K.G. and Scott, M.E. (2001) Gastrointestinal nematodes, nutrition and immunity: Breaking the negative spiral. Annual Review of Nutrition, 21, 297-321. doi:10.1146/annurev.nutr.21.1.297
[17] Chandra, R.K. (1993) Nutrition immunity and infection: Present knowledge and future direction. Lancet, 1, 688- 691.
[18] Lynch, N.R., Hagel, I.A., Palengie, M.E., Diprisco, M.C., Esandero, J.E., Cozao, L.A., Sandia, J.A., Ferreira, L.J., Botto, C., Perez, M. and Le Souef, P.N. (1998) Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. Journal of Allergy and Clinical Immunology, 101, 217- 221. doi:10.1016/S0091-6749(98)70386-0
[19] Gounni, A.S., Lamkhiooued, B. and Ochiai, K. (1994) High-affinity IgE receptor on eosinophils in involved in defense against parasites. Nature, 367, 183-186. doi:10.1038/367183a0
[20] Sutton, B.J. and Gould, H.J. (1993) The human IgE network. Nature, 366, 421-428. doi:10.1038/366421a0

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.