Evaluation of Some Biological Activities of Albizia lebbeck Flowers

Mohamed Farag, Ali El Gamal, Ashraf Kalil, Adnan Al-Rehaily, Omar El Mirghany, Kamal El Tahir

Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA;.
Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA; Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA; Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt;.
Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA..

DOI: 10.4236/pp.2013.46068                

Abstract

Reviewing the current literature for the importance of the plant Albizia lebbeck L. growing worldwide revealed many biological interests. However, the species growing in Saudi Arabia has not received due attention. The present study was undertaken to study antipyretic, analgesic, estrogenic and anti-inflammatory activities of five different fractions from successive extraction of Albizia lebbeck flowers: n hexane, dichloromethane, ethyl acetate, n-butanol as well as the 70% total alcohol. The flowers showed reasonable antipyretic, analgesic, estrogenic and anti-inflammatory activities.

Keywords

Herbal Medicine; Albizia lebbeck; Anti-Inflammatory Effect; Antipyretic Effect; Analgesic Effect; Estrogenic Effect

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	A. M. Migahid, “Flora of Saudi Arabia: ALBIZIA; Albizia L.,” 3rd Edition, Riyadh University Publication, Riyadh, 1989, p. 8.
[2]	Government of India, The Ministry of Health & Family Welfare, “Ayurvedic Pharmacopoeia of India,” The Controller of Publication, Delhi, 2001, pp. 201-202.
[3]	C. C. Baruach, P. P. Gupta, G. K. Patnaik, D. K. Kulshreshtha and B. N. Dhawan, “Anti Anaphylactic and Mast Cell Stabilizing Activity of Albizzia lebbeck,” Indian Journal of Veterinary Medicine, Vol. 21, No. 2, 1997, pp. 127-132.
[4]	N. P. Babu, P. Pandikumar and S. Ignacimuthu, “AntiInflammatory Activity of Albizia lebbeck Benth., an Ethnomedicinal Plant, in Acute and Chronic Animal Models of Inflammation,” Journal of Ethnopharmacology, Vol. 125, No. 2, 2009, pp. 356-360. doi:10.1016/j.jep.2009.02.041
[5]	K. Sanjay, “Saponins of Albizia lebbek in Alzheimer’s and Parkinson’s Disease,” Indian Journal of Natural Products, Vol. 19, No. 1, 2003, pp. 42-48.
[6]	V. S. Kasture, S. B. Kasture and S. C. Pal, “Anticonvulsant Activity of Albizzia lebbeck Leaves,” Indian Journal of Experimental Biology, Vol. 34, No. 1, 1996, pp. 78-80.
[7]	S. D. Chintawar, R. S. Somani, V. S. Kasture and S. B. Kasture, “Nootropic activity of Albizzia lebbeck in Mice,” Journal of Ethnopharmacology, Vol. 81, No. 3, 2002, pp. 299-305. doi:10.1016/S0378-8741(02)00140-X
[8]	C. R. Resmi, M. R. Venukumar and M. S. Latha, “Antioxidant Activity of Albizzia lebbeck (Linn.) Benth. in Alloxan Diabetic Rats,” Indian Journal of Physiology and Pharmacology, Vol. 50, No. 3, 2006, pp. 297-302.
[9]	Y. N. Singh, H. Bisht and D. Panday, “Effect of Dry Seed Extract of a Medicinal Plant Albizzia lebbeck on Testicular and Epididymal Protein Profiles of Rat,” Himalayan Journal of Environment and Zoology, Vo. 5, No. 1, 1991, pp. 94-108.
[10]	S. E. Besra, A. Gomes, L. Chaudhary, J. R. Vedasiromoni and D. K. Ganguly, “Antidiarrhoeal Activity of Seed Extract of Albizzia lebbeck Studied on Conventional Rodent Models of Diarrhe,” Phytotherapy Research, Vol. 16, No. 6, 2002, pp. 529-530. doi:10.1002/ptr.961
[11]	J. Kang, C. H. Huo, Z. Li and Z. P. Li, “New Ceramides from the Flower of Albizia julibrissin,” Chinese Chemical Letters, Vol. 18, No. 2, 2007, pp. 181-184. doi:10.1016/j.cclet.2006.12.042
[12]	Z. Yongna, R. Wantana, B. Pisit, L. Zhongkun and Z. Rongping, “Analgesic and Antipyretic Activities of the Aqueous Extract of Urtica macrorrhiza in Experimental Animals,” Fitoterapia, Vol. 76, No. 1, 2005, pp. 91-95. doi:10.1016/j.fitote.2004.10.018
[13]	G. E. Leighton, M. A. Johnson, K. G. Meecham, R. G. Hill and J. Hughes, “Pharmacological Profile of PD 117302, a Selective K-Opioid Agonist,” British Journal of Pharmacology, Vol. 92, No. 4, 1987, pp. 915-922. doi:10.1111/j.1476-5381.1987.tb11398.x
[14]	K. El Tahir, “A Guide to Drug Discovery: Directions for Pharmacological Screening for New Synthetic and Natural Compounds Leading to Discovery of New Medicines,” El Tahir Publication, Riyadh, 2007, pp. 100-105.
[15]	A. Kumar and P. Pakrasi, “Estrogenic and Antiestrogenic Properties of Clomiphene Citrate in Laboratory Mice,” Journal of Bioscience, Vol. 20, No. 5, 1995, pp. 665-673. doi:10.1007/BF02703306
[16]	G. S. Duncan, S. H. Peers, F. Carey, R. Forder and R. J. Flower, “Calcium Antagonistic and Antiarrhythmic Actions of CPU-23, a Substituted Tetrahydroisoquinoline,” British Journal of Pharmacology, Vol. 109, No. 1, 1993, pp. 113-119. doi:10.1111/j.1476-5381.1993.tb13539.x
[17]	N. Verma and R. K. Srivastav, “Analgesic, Antipyretic and Anti-Inflammatory Activities of Albizia lebbeck Seeds,” Pharmacology Online, Vol. 3, 2011, pp. 1209-1216.
[18]	A. Saha and M. Ahmed, “The Analgesic and Anti-Inflammatory Activities of the Extract of Albizia lebbeck in Animal Model,” Pakistanian Journal of Pharmaceutical Science, Vol. 22, No. 1, 2009, pp.74-77.
[19]	R. S. Gupta, J. S. Kachhawa and R. Chaudhary, “Antifertility Effects of Methanolic Pod Extract of Albizzia lebbeck (L.) Benth in Male Rats,” Asian Journal of Andrology, Vol. 6, No. 2, 2004, pp. 155-159.