The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis ()
Abstract
In the present study, we developed silicosis of
rat model by bronchial perfusion SiO2 dust, and intervenes with
AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung
tissue, and positive cells were counted. We found that compared with silicotic
model group, the positive cells of NF-κb and MCP-1 were decreased significantly
in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb
and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of
macrophage infiltration in lung tissue and reduced the degree of dust
alveolitis.
Share and Cite:
Q. Li, F. Yang, L. J. Zhang, H. Xu and W. L. Zhang, "The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis," International Journal of Clean Coal and Energy, Vol. 2 No. 2B, 2013, pp. 24-26. doi: 10.4236/ijcce.2013.22B006.
Conflicts of Interest
The authors declare no conflicts of interest.
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