Evaluation of the Protection against Infectious Bursal Disease (IBD) Challenge in Progeny Born to Parents Having Received a Vaccination Program Using a Herpesvirus of Turkey-Infectious Bursal Disease (HVT-IBD) Vector Vaccine


Broiler breeder vaccination against IBD is usually based on the injection of at least one inactivated vaccine in oil adjuvant, typically included in a combined vaccine. Priming using one or several IBD vaccine (s) has been the most common way to immunize the breeders so far. In summary, protection against vvIBD challenge in chicks of one commercial genetic line vaccinated in ovo with the HVT-IBD vector vaccine was demonstrated. The parents’ IBD vaccination program, using the HVT-IBD vector vaccine alone, the HVT-IBD vector vaccine plus IBD inactivated vaccine, and inactivated IBD vaccine alone, did not impair their progeny’s in ovo HVT-IBD vector vaccine take and subsequent protection against vvIBD virus challenge. An advantage in terms of immunization of the progeny against vvIBD was shown in the chicks born to breeders vaccinated with the HVT-IBD vaccine as a primer, as compared to breeders vaccinated with the inactivated vaccine alone. High level of IBD maternally-derived antibodies transmitted to the progeny by their parents induces together with an early onset of immunity by in ovo injection of a HVT-IBD vector vaccine clinical protection, as monitored on bursas, after vvIBD virus challenge.

Share and Cite:

S. Lemiere, J. Gauthier, A. Kodjo, L. Vinit, A. Delvecchio and F. Prandini, "Evaluation of the Protection against Infectious Bursal Disease (IBD) Challenge in Progeny Born to Parents Having Received a Vaccination Program Using a Herpesvirus of Turkey-Infectious Bursal Disease (HVT-IBD) Vector Vaccine," World Journal of Vaccines, Vol. 3 No. 2, 2013, pp. 46-51. doi: 10.4236/wjv.2013.32008.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] H. E. Müller, E. Mundt, N. Eterradossi and M. R. Islam, “Current Status of Vaccines against Infectious Bursal Disease,” Avian Pathology, Vol. 41, No. 2, 2012, pp. 133-139. doi:10.1080/03079457.2012.661403
[2] H. K. Block, K. Meyer-Block, D. E. Rebeski, H. Scharr, S. de Wit, K. Rohn and S. Rautenschlein, “A Field Study on the Significance of Vaccination against Infectious Bursal Disease Virus (IBDV) at the Optimal Time Point in Broiler Flocks with Maternally Derived IBDV Antibodies,” Avian Pathology, Vol. 36, No. 5, 2007, pp. 401-409. doi:10.1080/03079450701589175
[3] T. P. van den Berg and G. Meulemans, “Acute Infectious Bursal Disease in Poultry; Protection Afforded by Maternally Derived Antibodies and Interference with Live Vaccination,” Avian Pathology, Vol. 20, No. 3, 1991, pp. 409-421. doi:10.1080/03079459108418779
[4] N. J. Chettle, J. C. Stuart and P. J. Wyeth, “Outbreak of Virulent Infectious Bursal Disease in East Anglia,” Veterinary Record, Vol. 125, No. 10, 1989, pp. 271-272. doi:10.1136/vr.125.10.271
[5] T. P. van den Berg, M. Gonze and G. Meulemans, “Acute Infectious Bursal Disease in Poultry: Isolation and Characterisation of a Highly Virulent Strain,” Avian Pathology, Vol. 20, No. 1, 1991, pp. 133-143. doi:10.1080/03079459108418748
[6] T. P. van den Berg, “Acute Infectious Bursal Disease in Poultry: A Review,” Avian Pathology, Vol. 29, No. 3, 2000, pp. 175-194. doi:10.1080/03079450050045431
[7] D. J. Jackwood, S. E. Sommer-Wagner, A. S. Stoute, P. R. Woolcock, B. M. Crossley, S. K. Hietala and B. R. Charlton, “Characteristics of a Very Virulent Infectious Bursal Disease from California,” Avian Diseases, Vol. 53, No. 4, 2009, pp. 592-600. doi:10.1637/8957-061109-Reg.1
[8] J. C. Muskett, I. G. Hopkins, K. R. Edwards and D. H. Thornton, “Comparison of Two Infectious Bursal Disease Vaccine Strains: Efficacy and Potential Hazards in Susceptible and Maternally Immune Birds,” Veterinary Record, Vol. 104, No. 15, 1979, pp. 332-334. doi:10.1136/vr.104.15.332
[9] R. A. Maas, S. Venema, H. L. Oei, J. M. A. Pol, I. J. T. M. Claassen and A. A. H. T. M. ter Huurne, “Efficacy of Inactivated Infectious Bursal Disease (IBD) Vaccines: Comparison of Serology with Protection of Progeny Chickens against IBD Virus Strains of Varying Virulence,” Avian Pathology, Vol. 30, No. 4, 2001, pp. 345- 354. doi:10.1080/03079450120066359
[10] M. Bublot, N. Pritchard, F. X. Le-Gros and S. Goutebroze, “Use of a Vectored Vaccine against Infectious Bursal Disease of Chickens in the Face of High-Titred Maternally Derived Antibody,” Journal of Comparative Pathology, Vol. 137, Sup 1, 2007, pp. S81-S84.
[11] S. Goutebroze, M. Curet, M. L. Jay, C. Roux and F. X. Le-Gros, “Efficacy of a Recombinant Vaccine HVT-VP2 against Gumboro Disease in the Presence of Maternal Antibodies,” British Poultry Science, Vol. 44, No. 5, 2003, pp. 824-825. doi:10.1080/00071660410001667051
[12] S. Lemiere, S. Y. Wong, A. L. Saint-Gerand, S. Goutebroze and F. X. Le-Gros, “Compatibility of Turkey Herpesvirus-Infectious Bursal Disease Vector Vaccine with Marek’s Disease Rispens Vaccine Injected into Day-Old Pullets,” Avian Diseases, Vol. 55, No. 1, 2011, pp. 113-118. doi:10.1637/9507-081810-ResNote.1
[13] F. X. Le-Gros, A. Dancer, C. Giacomini, L. Pizzoni, M. Bublot, M. Graziani and F. Prandini, “Field Efficacy Trial of a Novel HVT-IBD Vector Vaccine for 1-Day-Old Broilers,” Vaccine, Vol. 27, No. 4, 2009, pp. 592-596. doi:10.1016/j.vaccine.2008.10.094
[14] R. Darteil, M. Bublot, E. Laplace, J. F. Bouquet, J. C. Audonnet and M. Riviere, “Herpesvirus of Turkey Recombinant Viruses Expressing Infectious Bursal Disease Virus (IBDV) VP2 Immunogen Induce Protection against an IBDV Virulent Challenge in Chickens,” Virology, Vol. 211, No. 2, 1995, pp. 481-490. doi:10.1006/viro.1995.1430
[15] J. M. Sharma, J. E. Dohmas and A. L. Metz, “Comparative Pathogenesis of Serotype 1 Isolates of Infectious Bursal Disease Virus and Their Effect on Humoral and Cellular Immune Competence of Specific-Pathogen-Free Chickens,” Avian Diseases, Vol. 33, No. 1, 1989, pp. 112-124. doi:10.2307/1591076
[16] W. Solano, J. J. Giambrone and V. S. Panangala, “Comparison of a Kinetic-Based Enzyme-Linked Immunosorbent Assay (KELISA) and Virus-Neutralization Test for Infectious Bursal Disease Virus. II. Decay of Maternal Antibody in Progeny from White Leghorns Receiving Various No. 1, s Vaccination Regimens,” Avian Diseases, Vol. 30, No. 1, 1986, pp. 126-131. doi:10.2307/1590623
[17] A. S. Abdel-Moneim and M. M. A. Abdel-Gawad, “Genetic Variations in Maternal Transfer and Immune Re- sponsiveness to Infectious Bursal Disease Virus,” Veterinary Microbiology, Vol. 114, No. 1-2, 2006, pp. 16-24. doi:10.1016/j.vetmic.2005.10.037

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.