Isolated Multifocal Sclerosing Thyroiditis: Case Report


Multifocal fibrosclerosis is a very rare fibroproliferative syndrome involving multiple organ systems. In our report we present the case of multifocal sclerosing thyroiditis characterized by multiple fibroelastic foci similar to breast “radial scar”, which can be misdiagnosed as multifocal papillary carcinoma. The diagnosis of multifocal sclerosing thyroiditis, in according with Armed Forces Institute of Pathology (AFIP) textbook on thyroid tumors, was made only after histological and himmunohistochemical examination. We consider the multifocal sclerosing thyroiditis as the first stage of multifocal IgG4-related sclerosing disease for the presence of IgG4 within fibrosclerotic tissue of thyroid. Total body CT-scan and plamatic IgG4 levels must be investigated in order to exclude or confirm the presence of systemic disease.

Share and Cite:

A. Paliotta, G. Pedullà, D. Crocetti, G. Cavallaro, G. D’Ermo, A. Polistena and G. Toma, "Isolated Multifocal Sclerosing Thyroiditis: Case Report," Surgical Science, Vol. 4 No. 3, 2013, pp. 213-215. doi: 10.4236/ss.2013.43040.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. K. Ormond, “Bilateral Ureteral Obstruction Due to Envelopment and Compression by an Inflammatory Retroperitoneal Process,” The Journal of Urology, Vol. 59, No. 6, 1948, pp. 1072-1079.
[2] N. R. Barrett, “Idiopathic Mediastinal Fibrosis,” The British Journal of Surgery, Vol. 46, No. 147, 1958, pp. 207-218. doi:10.1002/bjs.18004619703
[3] D. E. Comings and K. B. Skubi, “Familial Multifocal Fibrosclerosis,” Annals of Internal Medicine, Vol. 66, No. 5, 1967, pp. 884-892.
[4] G. Hamed and K. Tsushima, “Inflammatory Lesions of the Lung, Submandibular Gland, Bile Duct and Prostate in a Patient with IgG4-Associated Multifocal Systemic Fibrosclerosis,” Respirology, Vol. 12, No. 3, 2007, pp. 455-457. doi:10.1111/j.1440-1843.2007.01053.x
[5] M. David and M. D. Yousem, “Thyroid and Parathyroid Gland Pathology: Role of Imaging,” Otolaryngologic Clinics of North America, Vol. 28, No. 3, 1995, pp. 621-649.
[6] J. Rosai, “Tumors of the Thyorid Gland,” 3rd Series, Armed Forces Institute of Pathology, Washington DC, 1992.
[7] R. D. Lait and S. G. Hubsher, “Sclerosing Cholangitis Associated with Multifocal Fibrosis: A Case Report,” Gut, Vol. 33, No. 10, 1992, pp. 1430-1432. doi:10.1136/gut.33.10.1430
[8] G. W. Aylward and T. J. Sullivan, “Orbital Involvement in Multifocal Fibrosclerosis,” The British Journal of Ophtalmology, Vol. 79, No. 3, 1995, pp. 246-249. doi:10.1136/bjo.79.3.246
[9] A. Oezgen and A. Cila, “Riedel’s Thyroiditis in Multifocal Fibrosclerosis: CT and MR Imaging Findings,” American Journal of Neuroradiology, Vol. 21, No. 2, 2000, pp. 320-321.
[10] K. Hirabayashi and G. Zamboni, “IgG4-Related Disease,” Pathologica, Vol. 104, No. 2, 2012, pp. 43-55.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.