Expressions of CCR7 and CXCR4 Are Associated with Differentiation in Gastrointestinal Cancer


Purpose: The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer invasion and metastasis. This study was aimed to investigate CCR7 and CXCR4 expressions and evaluate the association between their expressions and the clinicopathological features in gastrointestinal cancer. Method: 27 paired tissue samples from patients who had curative surgery for gastrointestinal cancer were obtained. Quantitative real-time PCR, immunochemistry assay and western blot analysis were carried out to investigate the expressions of CCR7, CXCR4 expressions in gastrointestinal cancer. Results: The cancer tissues expressed significant higher level of CCR7 (P = 0.000) and CXCR4 (P = 0.000) protein than the adjacent normal mucosa. Expressions of CCR7 (P = 0.002) and CXCR4 (P = 0.003) protein in cancer tissues exhibited significant correlation with differentiation in gastrointestinal cancer. Conclusion: Expressions of CCR7 and CXCR4 protein were associated with differentiation in gastrointestinal cancer. CCR7 and CXCR4 may be predictive factors for poor prognosis in patients with gastrointestinal cancer.

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C. Lu, S. Chen, F. Xu, Y. Chen, Q. Zhang and Y. Li, "Expressions of CCR7 and CXCR4 Are Associated with Differentiation in Gastrointestinal Cancer," Journal of Cancer Therapy, Vol. 4 No. 1A, 2013, pp. 49-53. doi: 10.4236/jct.2013.41A007.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] M. Baggiolini, B. Dewald and B. Moser, “Human Chemokines: An Update,” Annual Review of Immunology, Vol. 15, 1997, pp. 675-705. doi:10.1146/annurev.immunol.15.1.675
[2] B. J. Rollins, “Chemokines,” Blood, Vol. 90, No. 3, 1997, pp. 909-928.
[3] G. S. Kelner, J. Kennedy, K. B. Bacon, et al., “Lymphotactin: A Cytokine That Represents a New Class of Chemokines,” Science, Vol. 266, No. 5189, 1994, pp. 1395-1399. doi:10.1126/science.7973732
[4] R. M. Ransohoff, “Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology,” Immunity, Vol. 31, No. 5, 2009, pp. 711-721. doi:10.1016/j.immuni.2009.09.010
[5] A. Rot and U. H. von Andrian, “Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells,” Annual Review of Immunology, Vol. 22, No. 1, 2004, pp. 891-928. doi:10.1146/annurev.immunol.22.012703.104543
[6] G. Lazennec and A. Richmond, “Chemokines and Chemokine Receptors: New Insights into Cancer-Related Inflammation,” Trends in Molecular Medicine, Vol. 16, No. 3, pp. 133-144. doi:10.1016/j.molmed.2010.01.003
[7] R. C. Kruizinga, J. Bestebroer, P. Berghuis, C. J. de Haas, T. P. Links, E. G. de Vries, et al., “Role of Chemokines and Their Receptors in Cancer,” Current Pharmaceutical Design, Vol. 15, No. 29, 2009, pp. 3396-3416. doi:10.2174/138161209789105081
[8] A. Zlotnik, “Chemokines and Cancer,” International Journal of Cancer, Vol. 119, No. 9, 2006, pp. 2026-2029. doi:10.1002/ijc.22024
[9] J. Kim, H. Takeuchi, S. T. Lam, R. R. Turner, H. J. Wang, C. Kuo, L. Foshag, A. J. Bilchik and D. S. Hoon, “Chemokine Receptor CXCR4 Expression in Colorectal Cancer Patients Increases the Risk for Recurrence and for Poor Survival,” Journal of Clinical Oncology, Vol. 23, No. 12, 2005, pp. 2744-2753. doi:10.1200/JCO.2005.07.078
[10] C. C. Schimanski, P. R. Galle and M. Markus, “Chemokine Receptor CXCR4-Prognostic Factor for Gastrointestinal Tumors,” World Journal of Gastroenterology, Vol. 14, No. 30, 2008, pp. 4721-4724.
[11] C. C. Schimanski, S. Schwald, N. Simiantonaki, C. Jayasinghe, U. Gonner, V. Wilsberg, T. Junginger, M. R. Berger, P. R. Galle and M. Moehler, “Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer,” Clinical Cancer Research, Vol. 11, No. 5, 2005, pp. 1743-1750. doi:10.1158/1078-0432.CCR-04-1195
[12] Y. Lou, J. Cai, H. Xue, et al., “Functional SDF1 Alpha/CXCR4 Signaling in the Developing Spinal Cord,” Journal of Neurochemistry, Vol. 93, No. 2, 2005, pp. 452-462. doi:10.1111/j.1471-4159.2005.03049.x

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