Misleading New Entity in Tumors of Kidney: A Case Report and Literature Review


Introduction: Mucinous tubular and spindle cell carcinomas (MTSCC's) are recently described rare type of renal cell carcinoma (RCC). They may have morphological similarities to papillary RCC (papRCC) and in our case to carcinoma collecting ducts of Bellini. Case report: We report a rare case of renal tumor, mucinous tubular and spindle cell carcinoma in a 56-year-old woman. The tumor, located in the left kidney, was well circumscribed. MTSCC's are characterized by small, elongated tubules lined by cuboidal cells and/or cords of spindled cells separated by pale mucinous stroma. Discussion: MTSCC is a rare type of renal cell carcinoma. Pathologists should be aware of the histological spectrum of MTSCCs to ensure an accurate diagnosis. Careful attention to the presence of a spindle cell population may be helpful in the differential diagnosis in tumors with predominant compact tubular growth.

Share and Cite:

E. Fatemi Hinde, H. Nawal, H. Imane, T. Fadl, E. Jamal and A. Afaf, "Misleading New Entity in Tumors of Kidney: A Case Report and Literature Review," Open Journal of Urology, Vol. 2 No. 4, 2012, pp. 219-222. doi: 10.4236/oju.2012.24039.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] A. V. Parwani, A. N. Husain, J. I. Epstein, J. B. Beckwith and P. Argani, “Lowgrade Myxoid Renal Epithelial Neoplasms with Distal Nephron Differentiation,” Human Pathology, Vol. 32, No. 5, 2001, pp. 506-512. doi:10.1053/hupa.2001.24320
[2] J. N. Eble, G. Sauter, J. I. Epstein and I. A. Sesterhenn, “World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs,” International Agency for Research on Cancer (IARC), Lyon, 2004.
[3] O. Hes, M. Hora, D. M. Perez-Montiel, S. Suster, R. Curik, L. Sokol, et al., “Spindle and Cuboidal Renal Cell Carcinoma, a Tumour Having Frequent Association with Nephrolithiasis: Report of 11 Cases including a Case with Hybrid Conventional Renal Cell Carcinoma/Spindle and Cuboidal Renal Cell Carcinoma Components,” Histopathology, Vol. 41, No. 6, 2002, pp. 549-555. doi:10.1046/j.1365-2559.2002.01515.x
[4] C. Rakozy, G. E. Schmahl, S. Bogner and S. Storkel, “Low-Grade Tubularmucinous Renal Neoplasms: Morphologic, Immunohisto-Chemical, and Genetic Features,” Modern Pathology, Vol. 15, No. 11, 2002, pp. 1162-1171. doi:10.1097/01.MP.0000031709.40712.46
[5] G. P. Paner, J. R. Srigley, A. Radhakrishnan, et al., “Immunohistochemical Analysis of Mucinous Tubular and Spindle Cell Carcinoma and Papillary Renal Cell Carcinoma of the Kidney: Significant Immunophenotypic Overlap Warrants Diagnostic Caution,” American Journal of Surgical Pathology, Vol. 30, No. 1, 2006, pp. 13-19. doi:10.1097/01.pas.0000180443.94645.50
[6] S. W. Fine, P. Argani, DeMarzo, et al., “Expanding the Histologic Spectrum of Mucinous Tubular and Spindle Cell Carcinoma of the Kidney,” American Journal of Surgical Pathology, Vol. 30, No. 12, 2006, pp. 1554-1560. doi:10.1097/01.pas.0000213271.15221.e3
[7] R. Srigley, “Mucinous Tubular and Spindle Cell Carcinoma,” In: J. N. Eblc, G. Sauter, J. I. Epstein, I. A. Sesterhenn, Eds., World Health Organization Classification of Tumours: Pathology and Genetics. Tumours of Urinary System and Male Genital Organs, Lyon, IARC Press, 2004, p. 40.
[8] S. S. Shen, J. Y. Ro, P. Tamboli, et al., “Mucinous Tubular and Spindle Cell Carcinoma of Kidney is Probably a Variant of Papillary Renal Cell Carcinoma with Spindle Cell Features,” Annals of Diagn Pathology, Vol. 11, No. 1, 2007, pp. 13-21. doi:10.1016/j.anndiagpath.2006.09.005
[9] V. A. Sahni, M. S. Hirsch, C. A. Sadow, S. G. Silverman, “Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: Imaging Features,” Cancer Imaging, Vol. 5, No. 12, 2012, pp. 66-71. doi:10.1102/1470-7330.2012.0008
[10] N. Kuroda, O. Hes, M. Michal, et al., “Mucinous Tubular and Spindle Cell Carcinoma with Fuhrman Nuclear Grade 3: A Histological, Immunohistochemical, Ultrastructural and FISH Study,” Histological Histopathology, Vol. 23, No. 12, 2008, pp. 1517-1523.
[11] N. Pillay, P. K. Ramdial, K. Cooper, et al., “Mucinous Tubular and Spindle Cell Carcinoma with Aggressive Histomorphology—A Sarcomatoid Variant,” Human Pathology, Vol. 39, No. 6, 2008, pp. 966-969. doi:10.1016/j.humpath.2007.10.006
[12] S. Bulimbasic, Ljubanovic, R. Sima, et al., “Aggressive High-Grade Mucinous Tubular and Spindle Cell Carcinoma,” Human Pathology, 2009, Vol. 40, No. 6, pp. 906-907. doi:10.1016/j.humpath.2009.03.004
[13] S. Ferlicot, Y. Allory, E. Compérat, et al., “Mucinous Tubular and Spindle Cell Carcinoma: A Report of 15 Cases and Review of the Literature,” Virchows Archive, Vol. 477, No. 6, 2005, pp. 978-983. doi:10.1007/s00428-005-0036-x
[14] P. Brandle, A. K. Lie, A. Bassarova, et al., “Genomic Aberrations in Mucinous Tubular and Spindle Cell Renal Cell Carcinomas,” Modern Pathology, Vol. 19, No. 2, 2006, pp. 186-194. doi:10.1038/modpathol.3800499
[15] S. A. Gadre, S. K. Math, K. A. Elfeel and H. Farghaly, “Cytology of a Sarcomatoid Renal Cell Carcinoma with Unusual Coexpression of S-100 Protein: A Case Report, Review of the Literature and Cytologic-Histologic Correlation,” Diagn Cytopathology, Vol. 37, No. 3, 2009, pp. 195-198. doi:10.1002/dc.21003
[16] G. Kovacs, M. Akhtar, B. J. Beckwith, P. Bugert, C. S. Cooper, B. Delahunt, et al., “The Heidelberg Classification of Renal Cell Tumours,” Journal of Pathology, 1997, Vol. 183, No. 2, pp. 131-133. doi:10.1002/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G
[17] M. de Peralta-Venturina, H. Moch, M. Amin, P. Tamboli, S. Hailemariam, M. Mihatsch, et al., “Sarcomatoid Differentiation in Renal Cell Carcinoma: A Study of 101 Cases,” American Journal of Surgical Pathology, 2001, Vol. 25, No. 3, pp. 275-284. doi:10.1097/00000478-200103000-00001
[18] L. D. Truong and S. S. Shen, “Immunohistochemical Diagnosis of Renal Neoplasms,” Archive Pathological of Lab Medicine, Vol. 135, No. 12, 2011, pp. 92-109.
[19] S. Sen, B. Sars, A. Simsir, E. Kmal and E. Gokmen, “Bobrekte Kitle Nedeniyle Yapilan Igne Kor Biyopsileri ve Tani Zorluklari,” Turk Patoloji Derg, Vol. 26, No. 2, 2010, pp. 5-18.
[20] P. Cossu-Rocca, J. N. Eble, B. Delahunt, S. Zhang, G. Martignoni, M. Brunelli and L. Cheng, “Renal Mucinous Tubular and Spindle Carcinoma Lacks the Gains of Chromosomes 7 and 17 and Losses of Chromosome Y that Are Prevalent in Papillary Renal Cell Carcinoma,” Modern Pathology, Vol. 19, No. 14, 2006, pp. 488-493. doi:10.1038/modpathol.3800565
[21] P. Argani, G. J. Netto and A. V. Parwani, “Papillary Renal Cell Carcinoma with Low-Grade Spindle Cell Foci: A Mimic of Mucinous Tubular and Spindle Cell Carcinoma,” American Journal of Surgical Pathology, Vol. 32, No. 9, 2008, pp. 1353-1359. doi:10.1097/PAS.0b013e31816a1c34

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.