A review of HELLP syndrome, in 17 patients


Introduction Preeclampsia is a well known obstetric complication characterized with hypertension and proteinuria whereas HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count) which was first stated by Prichard in 1954 and described by Weinstein in 1982, is a multisystemic disease usually seen in the third trimester and in the postpartum period, usually in 48 - 72 hours following delivery [1]. Aim In this study we aim to share our experience in 17 patients with HELLP syndrome treated in our clinic between January 2005 and March 2008 in regard of the current literature. Material and Methods 17 patients diagnosed with HELLP syndrome between January 2005 and March 2008 were retro-spectively re-evaluated in regard of symptoms, treatment options and prognosis. As such this is a retro-spective study focusing on case reports. Conclusion As noted before main focus of treatment should be on patient stability, in other words, palliative care under intensive care conditions.

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Güven, D. , Bakay, K. , Koçak, İ. and Üstün, C. (2012) A review of HELLP syndrome, in 17 patients. Open Journal of Obstetrics and Gynecology, 2, 318-320. doi: 10.4236/ojog.2012.23066.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Weinstein, L. (1982) Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancy. American Journal of Obstetrics & Gynecology, 142, 159-167.
[2] Sezik, M., Ozkaya, M.O., Sezik, H.T., Yapar, E. and Kaya, H. (2005) HELLP sendromlu hastalarda umblikal arter doppler incelemesinin perinatal sonuclarla iliskisi. Perinatoloji Dergisi, 13, 198-202.
[3] Loos/Rath (1992) Das HELLP-syndrom-ein “gestaltwandel der praeklampsie”. Geburtsh. u. Frauenheilk, 52, 581-585.
[4] Keles, G.T., Topcu, I., Kefi, A., Ekinci, Z. and Sakarya, M. (2006) Yogun bakim unitesinde obstetrik olgular. Firat Tip Dergisi, 11, 62-65.
[5] Weinstein, L. (1985) Preeclampsi/eclampsi with hemolysis, ele vated liver enzymes and trombocytopenia. Obstetrics & Gynecology, 66, 657.
[6] Sibai, B.M., Taslimi, M.M., EL-Nazer, A., Aman, E., Mabie, B.C. and Ryan, G.M. (1986) Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe pre-eclampsia, eclampsia. American Journal of Obstetrics & Gynecology, 155, 501-509.
[7] Tsoe, E., Reid, R.P., Barish, R.A. and Browne, B.J. (1987) Late past partum eclampsia. Annals of Emergency Medicine, 16, 907-909. doi:10.1016/S0196-0644(87)80533-4
[8] Sibai, B.M. and Ramadan, K.M. (1993) Acute renal failure in pregnancies comp licated by hemolysis, elevated liver enzymes, ad low platelets. American Journal of Obstetrics & Gynecology, 168, 1682-1690.
[9] Sibai, B.M., Villar, M.A. and Mabie, B.C. (1990) Acute renal failure in hypertensi ve disorders: Pregnancy outcome and remote prognosis in thirty-one consecutive cases. American Journal of Obstetrics & Gynecology, 162, 777-783.
[10] Kuhn, W., Rath, W., Loos, W. and Graeff, H. (1992) Le syndrome hellp. Resultats cliniques et d’analyse en laboratoire. Rev Fr Gynecol Obstet, 87, 323.
[11] Sibai, B.M. (2004) Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstetrics & Gynecology, 103, 981-991. doi:10.1097/01.AOG.0000126245.35811.2a
[12] Haddad, B., Barton, J.R., Livingston, J.C., Chahine, R. and Sibai, B.M. (2000) HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome versus severe preeclampsia: Onset at< or =28.0 weeks’ gestation. American Journal of Obstetrics & Gynecology, 183, 1475-1479. doi:10.1067/mob.2000.106975
[13] Rahman, T.M. and Wendan, J. (2002) Severe hepatic dysfunction in pregnancy. An International Journal of Medicine, 95, 343-357.
[14] Martin, J.N. Jr., Perry, K.G. Jr, Blake, P.G., May, W.A., Moore, A. and Robinette, L. (1997) Beter maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes and trombocytopenia) syndrome. American Journal of Obstetrics & Gynecology, 177, 1011-1017. doi:10.1016/S0002-9378(97)70005-X

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