Modifying action of heavy metal salts on an-ti-inflammatory aspirin action


Nowadays pollution of the environment is one of the major problems of mankind. Moreover, studying of the effect of different kinds of med- icine on selected, specially bred, non-exposed to external pollutants animals is becoming distant from reality. Thus in this work we have investigated the modifying action of heavy metals on anti-inflammatory effect of aspirin. The investigation were carried out on rats which were injected during 7 days intraperitoneally by PbCl3, HgCl2, CdCl2 in concentration of 100, 20, 1 mg/kg accordingly, modulating accumulation of the metals in the organism tissues. On the 8 days inflammation was invoked by formalin. As anti-inflammatory medicine was use aspirin. Judging by obtained results the conclusion can be drawn that cadmium in concentration 1 mg/kg significantly increases anti-inflammatory aspirin activity. The observed outcome can be explained in the following way. It is generally known that zinc in a certain concentration demonstrates anti-inflammatory properties. Be- ing an element of the same group cadmium has similar properties and also can have anti-inflammatory action. Lead and mercury suppre- ssed anti-inflammatory aspirin activity. Obvious inhibitory action of mercury and lead salts on aspirin action related to the fact that these elements by themselves were inflammation factors. From the obtained results the following conclusion can be drawn: a definite dose of anti-inflammatory medicine (aspirin) which is sufficient in normal conditions became less effective against the background of accumulation of ions of some heavy metals in an organism.

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Husainov, D. , Shylina, V. , Korenyuk, l. and Shulgin, V. (2010) Modifying action of heavy metal salts on an-ti-inflammatory aspirin action. Health, 2, 630-633. doi: 10.4236/health.2010.26095.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Duruibe, J.O., Ogwuegbu, M.O. and Egwurugwu, J.N. (2007) Heavy metal pollution and human biotoxic effects. International Journal of Physical Sciences, 2(5), 112- 118.
[2] Duffus, J.H. (2002) Chemistry and human health division clinical chemistry section, commission on toxicology. Applied Chemistry, 74(5), 793-807.
[3] Kumar, A., Dey, P.K., Singla, P.N., Ambasht, R.S. and Upadhyay, S.K. (1998) Blood lead levels in children with neurological disorders. Journal of Tropical Pediatrics, 44 (6), 320-322.
[4] Miranda, M., López-Alonso, M., Castillo, C., Hernández, J. and Benedito, J.L. (2005) Effects of moderate pollution on toxic and trace metal levels in calves from a polluted area of northern Spain. Environment International, 31(4), 543-548.
[5] Banks, E.C., Ferretti, L.E. and Shucard, D.W. (1997) Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology, 18(1), 237- 281.
[6] Brito, G., Díaz, C., Galindo, L., Hardisson, A., Santiago, D. and Montelongo G.F. (2005) Levels of metals in canned meat products: Intermetallic correlations. Bulletin of Environmental Contamination and Toxicology, 44(2), 309-316.
[7] Walkowiak, J., Altmann, L., Krämer, U., Sveinsson, K., Turfeld, M., Weishoff-Houben, M. and Winneke, G. (1998) Cognitive and sensorimotor functions in 6-year- old children in relation to lead and mercury levels: adjustment for intelligence and contrast sensitivity in computerized testing. Neurotoxicology and Teratology, 20(5), 511-521.
[8] Mameli, O., Caria, M.A., Metis, F., Solinas, A., Tavera, C., Ibba, A., Tocco, M., Flore, C. and Randaccio, S.F. (2001) Neurotoxic effect of lead at low concentrations. Brain Research Bulletin, 55(2), 269-275.
[9] Vane, J.R. and Botting, R.M. (1992) Aspirin and Other Salicylates. Chapman & Hall Medical, London.
[10] Fosmire, G.J. (1990) Zinc toxicity. American Journal of Clinical Nutrition, 51(2), 225-227.
[11] Abou-Mohamed, G., El-Kashef, H.A., Salem, H.A. and Elmazaf, M.M. (1995) Effect of Zinc on the Anti-Inflammatory and Ulcerogenic Activities of Indometacin and Diclofenac. Pharmacology, 50(4), 266-272.
[12] Sokolik, J., Tumova, I., Blahova, M. and Svajlenova, O. (2006) Anti-inflammatory activity of copper (II) and zinc (II) 3, 6-dimethylsalicylates and their equimolar mixture. Acta Facultatis Pharmaceuticae Universitatis Comenianae, 53, 224-228.
[13] Sokolik, J., Tumova, I., Blahova, M., Bernatova, M. and Svec, P. (2002) Anti-inflammatory activities of (o-cresotato) copper (II) and zinc (II) aqua complexes. Ceska Slov Farm, 51, 205-207.
[14] Eliasson, R. (1963) Prostaglandin: properties, actions and significance. Biochemical Pharmacology, 12, 405-412.

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