Can we achieve complete remission in locally advanced unresectable Hepatocellular Carcinoma (HCC) by using Sorafenib? Case report and review of literature from Qatar

Kakil Ibrahim Rasul

National Center for Cancer Care and Research (NCCCR), Doha, Qatar.

DOI: 10.4236/mc.2012.11001                

Abstract

Patients with HCC continue to have a dismal prognosis, with 1-year and 3-year survival rates of 36 and 17%, respectively. This is in part related to more than two-thirds of tumors being diagnosed at advanced stages, as well as a substantial portion of patients with early HCC failing to receive potentially curative treatments. Systemic therapy for advanced unresectable HCC limited until the discovery of sorafenib, we are reporting a 53 year patient with unresectable HCC achieved complete remission clinically, radiologically and biochemically with sorafenib which is the first case report.

Keywords

Hepatocellular Ca; Sorafenib; Chemoembolization

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	El-Serag, H.B., Siegel, A.B., Davila, J.A., et al. (2006) Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: A population-based study. Journal of Hepatology, 44, 158-166. doi:10.1016/j.jhep.2005.10.002
[2]	Josep, M. Llovet, M.D., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., et al. (2008) Sorafenib in advanced hepatocellular carcinoma. The New England Journal of Medicine, 359, 378-390. doi:10.1056/NEJMoa0708857
[3]	Cheng, A.L., Kang, Y.K., Chen, Z., Tsao, C.J., et al. (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. The Lancet Oncology, 10, 25-34. doi:10.1016/S1470-2045(08)70285-7
[4]	Forner, A., Hessheimer, A.J., Isabel Real, M., et al. (2006) Treatment of hepatocellular carcinoma. Critical Reviews in Oncology/Hematology, 60, 89-98. doi:10.1016/j.critrevonc.2006.06.001
[5]	Okuda, K. (2000) Hepatocellular carcinoma. Journal of Hepatology, 32, 225-237. doi:10.1016/S0168-8278(00)80428-6
[6]	Llovet, J.M., Bustamante, J., Castells, A., et al. (1999) Natural history of unresected nonsurgical hepatocellular carcinoma for the design and evaluation of therapeutic trials. Hepatology, 29, 62-67. doi:10.1002/hep.510290145
[7]	Okuda, K., Takayasu, K., Okada, S. (1997) Treatment selection. In: Okuda, K. and Tabor, E. Eds., Liver Cancer, Churchill-Livingstone, New York, 435-439.