Difference of the Pain during the DPT (Diphtheria-Pertussis-Tetanus) Vaccination


Background: The objective of this study is to determine whether analyze of the infant’s pain associated with diphtheria-pertussis-tetanus (DPT) immunization is useful for vaccination in children. It is not known whether the immunization pain can be prevented with the adequate choice of DPT vaccines among several manufacturers in Japan. Further, it is not clear whether the difference of the reaction during vaccination between gender and age. Design: Three manufacturer’s Japanese DPT vaccines were used in this study. The parents assessed their infant’s pain on a modified visual analogue scale (MVAS), the start of the crying and total crying time during the immunization. Results: The A manufacturer’s DPT vaccine was significantly lower on the proportion of crying, the duration of crying and MVAS score than the other two manufacturer’s DPT vaccines. The proportion of crying, the duration of crying and MVAS score was lower in the boy than in the girl. On the other hand, it had not found the difference of their reactions with age. Conclusions: Our studies have found that the adequate choice of DPT vaccine decreased vaccination pain. The studies also indicate that some tendencies with vaccinations were shown in children. To consider these tendencies was useful in performing less painful vaccination.

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Y. Tsuji, I. Ichihashi, K. Morita and K. Itabashi, "Difference of the Pain during the DPT (Diphtheria-Pertussis-Tetanus) Vaccination," World Journal of Vaccines, Vol. 2 No. 2, 2012, pp. 91-95. doi: 10.4236/wjv.2012.22012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] A. Taddio, A. Appleton, R. Bortolussi, et al., “Reducing the Pain of Childhood Vaccination: An Evidence-Based Clinical Practice Guideline (Summary),” Canadian Medical Association Journal, Vol. 182, No. 18, 2010, pp. 1989-1995. doi:10.1503/cmaj.092048
[2] L. A. Jackson, M. Dunstan, P. Starkovich, J. Dunn, O. Yu, J. C. Nelson, T. Rees and A. Zavitkovsky, “Prophylaxis with Acetaminophen or Ibuprofen for Prevention of Local Reactions to the Fifth Diphtheria-Tetanus Toxoids-Acellular Pertussis Vaccination: A Randomized, Controlled Trial,” Pediatrics, Vol. 117, No. 3, 2006, pp. 620-625. doi:10.1542/peds.2005-1217
[3] K. Terada, M. Inoue, T. Yamaguchi, et al., “Difference of Response in an Inoculation Site and Pain between Vaccines with Thimerosal or Phenoxyethanol,” Infection and Immunity in Childhood, Vol. 22, No. 2, 2010, pp. 145-150.
[4] K. A. Woodin, L. E. Rodewald, S. G. Humiston, M. S. Carges, S. J. Schffer and P. G. Szilagyi, “Are Children Becoming Pincushions from Immunizations?” Archives of Pediatrics & Adolescent Medicine, Vol. 149, No. 8, 1995, pp. 845-849. doi:10.1001/archpedi.1995.02170210019003
[5] M. Ipp, P. C. Parkin, N. Lear, M. Goldbach and A. Taddio “Order of Vaccine Injection and Onse,” Archives of Pediatrics & Adolescent Medicine, Vol. 163, No. 5, 2009, pp. 469-472. doi:10.1001/archpediatrics.2009.35
[6] L. L. Cohen, R. L. Blount, R. J. Cohen, E. R. Schaen and J. F. Zaff, “Comparative Study of Distraction versus Topical Anesthesia for Pediatric Pain Management during Immunizations,” Health Psychology, Vol. 18, No. 6, 1999, pp. 591-598. doi:10.1037/0278-6133.18.6.591
[7] R. M. Jacobson, A. Swan, A. Adegbenro, S. L. Ludington, P. C. Wollan and G. A. Poland, “Making Vaccines More Acceptable-Methods to Prevent and Minimaize Pain and Other Common Adverse Events Associated with Vaccines,” Vaccine, Vol. 19, No. 17-19, 2001, pp. 2418-2427. doi:10.1016/S0264-410X(00)00466-7
[8] T. Piira, G. D. Champion, T. Bustos, N. Donnelly and K. Lui “Factors Associated with Infant Pain Following an Immunization Injection,” Early Human Development, Vol. 83, No. 5, 2007, pp. 319-326. doi:10.1016/j.earlhumdev.2006.06.007
[9] G. B. Humphrey, C. M. Boon, G. F. van Linden van den Heuvell and H. B. van de Wiel, “The Occurrence of High Levels of Acute Behavioral Distress in Children and Adolescents Undergoing Routine Venipunctures,” Pediatrics, Vol. 90, No. 1, 1992, pp. 87-91.

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