Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy
Gilnardo Novelli, Vincenzo Morabito, Giancarlo Ferretti, Simone Novelli, Franco Ruberto, Milena Pernice, Cristina Cristina Donfrancesco, Perluigi Benedetti Panici
Department “Paride Stefanini” General Surgery and Organs Transplant, Sapienza University, Rome, Italy.
Department “Paride Stefanini” General Surgery and Organs Transplant, Sapienza University, Rome, Italy 2Department of.
Department of Anesthesia and Intensive Care, Sapienza University, Rome, Italy 5Department of.
Department of Clinical Engineering, Sapienza University, Rome, Italy.
Department of Gynecology and Obstretics, Sapienza University, Rome, Italy.
Department of Tropical and Infectous Disease, Sapienza University, Rome, Italy.
DOI: 10.4236/jbise.2012.53013   PDF    HTML     3,546 Downloads   6,432 Views   Citations


In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.

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Novelli, G. , Morabito, V. , Ferretti, G. , Novelli, S. , Ruberto, F. , Pernice, M. , Cristina Donfrancesco, C. and Panici, P. (2012) Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy. Journal of Biomedical Science and Engineering, 5, 101-103. doi: 10.4236/jbise.2012.53013.

Conflicts of Interest

The authors declare no conflicts of interest.


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