Sensitivity and Specificity of the CDC Empirical Chronic Fatigue Syndrome Case Definition


In an effort to bring more standardization to the chronic fatigue syndrome (CFS) Fukuda et al. case definition [1], the Centers for Disease Control and Prevention (CDC) has developed an empirical case definition [2] that specifies crite-ria and instruments to diagnose CFS. The present study investigated the sensitivity and specificity of this CFS em-pirical case definition with diagnosed individuals with CFS from a community based study that were compared to non-CFS cases. All participants completed questionnaires measuring disability (Medical Outcome Survey Short-Form-36) [3], fatigue (the Multidimensional Fatigue Inventory) [4], and symptoms (CDC Symptom Inventory) [5]. Findings of the present study indicated sensitivity and specificity problems with the CDC empirical CFS case defi-nition.

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Jason, L. , Evans, M. , Brown, A. , Brown, M. , Porter, N. , Hunnell, J. , Anderson, V. & Lerch, A. (2010). Sensitivity and Specificity of the CDC Empirical Chronic Fatigue Syndrome Case Definition. Psychology, 1, 9-16. doi: 10.4236/psych.2010.11002.

Conflicts of Interest

The authors declare no conflicts of interest.


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