Acute Myocardial Infarction (AMI) and Intermediate Coronary Syndrome (ICS)


In recent studies it was shown that blood co-agulation and inflammation markers are raising at high geomagnetic activity; acute myocardial infarction and all his subtypes, mostly related to atheromatous plaque disruption with higher Cosmic Ray (Neutron) activity. The aim of this study was to explore AMI and ICS differences by concomitant physical conditions, accompany-ing each of these acute coronary syndromes. The data was a part of MONICA international study in Kaunas, Lithuania in years 2000-2005 (72 consecutive months). 4633 patients with AMI (2461 men) and 961 with ICS (654 men), (age up to 65) were studied. For comparison four indices of Solar (SA), three of Geomagnetic (GMA), Cosmic Ray (CRA) measured by Neutron activity imp/min. were used. Cosmophysical data were from space science institutions in the USA and Russia. Pearson correlation coefficients and their probabilities were obtained.Monthly num-ber of AMI and ICS shows different links with the physical parameters: AMI were significantly in-verse related to SA (r=-0.4, p=0.0021) and direct to CRA (Neutron) activity (r=0.23, p=0.048). ICS was not correlated with these two parameters, but show significant links to GMA (r=0.25, p=0.037). Gender differences were evident, men more close related to changes in the mentioned physical parameters.Conclusion: 1. Monthly nu- mber of AMI and ICS is different related to fluc-tuations of environmental physical parameters. 2. The described connections can affect differ-ences in the pathogenesis of these forms of Acute Coronary Insufficiency.

Share and Cite:

Stoupel, E. , Tamoshiunas, A. , Radishauskas, R. , Bernotiene, G. , Abramson, E. , Sulkes, J. and Israelevich, P. (2010) Acute Myocardial Infarction (AMI) and Intermediate Coronary Syndrome (ICS). Health, 2, 131-136. doi: 10.4236/health.2010.22020.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Stoupel, E., Joshua, H., Lahav, J. (1996) Human blood coagulation parameters and geomagnetic activity. Eur J Int Med, 7, 217-220.
[2] Stoupel, E., Wittenberg, C., Zabludovski, J., Boner, G. (1995) Ambulatory blood pressure monitoring in patients with hypertension on days of high and low geomagnetic activity. J Human Hypertension, 9, 293-294.
[3] Stoupel, E., Abramson, E., Israelevich, P., Sulkes, J., Harell, D. (2007) Dynamics of serum C-reactive protein (CRP) level and cosmophysical activity. Eur J Int Med, 18(2), 124-128.
[4] Stoupel, E. (1980) Solar-terrestrial predictions: Aspects for preventive medicine in: Donnelly Ed. solar-terrestrial predictions. Vol 4. NOAA Space Environment Laboratory and USAF, Boulder, Co., USA, G29-G40.
[5] Oranevskii, V.N., Breus, T.K., Baevskii, R.M., Rappoprt, S.I., Petrov, V.M., Barsukova, Z.V. (1998) Effect of geo-magnetic activity on the functional status of the body. Biofizika, 43(5), 819-826.
[6] Stoupel, E., Domarkiene, S., Radishauskas, R., Bernotiene, G., Abramson, E., Israelevich, P., Sulkes, J. (2004) Links between monthly rates of four subtypes of acute myocar-dial infarction and their corresponding cosmophysical activity parameters. J Basic & Clin Physiol & Pharmacol, 15(3-4), 175-184.
[7] Gurfinkel, Y.I., Liubimov, V.V., Orajevskii, V.N., Par-fenova, L.M., Yurjev, A.S. (1995) The influence of geo-magnetic activity on capillary flow in ischemic heart disease patients. Biofizika, 40(4), 793-799.
[8] Nuzhdina, M.A. (1998) Effect of natural factors on the occurrence of cardiovascular diseases. Biofizika, 43(4) 640-646.
[9] Stoupel, E., Babayev, E., Mustafa, F., Abramson, E., Israelevich, P., Sulkes, J. (2007) Acute myocardial In-farction occurrence: Environmental links - Baku 2003-2005 data. Med Sc Monit, 13(8), BR 175-179.
[10] NOAA National Geophysical Data Center. Solar Indices Bulletin.
[11] NOAA National Geophysical Data Center. Geomagnetic Indices Bulletin.
[12] NOAA, SWPC –USAF Preliminary Report and Forecast of Solar Geophysical Data.
[13] Russian Academy of Sciences. Izmiran Institute. Cosmic Data.
[14] Russian Academy of Sciences. Moscow Neutron Moni-toring Data.
[15] Oulu University. Neutron Monitoring Data, 15.
[16] NOAA-USAF. (1988) SESC glossary of solar–terrestrial terms. Boulder, CO, USA, 1-69.
[17] Fuster, V. (1999) The vulnerable atherosclerotic plaque. Blackwell Publishing.
[18] Fuster, V., Fayad, Z.A., Badimon, J.J. (1999) Acute coro-nary syndromes. Lancet 353, Suppl., 2, S114-119.
[19] Libby, P., Ridker, P.M., Maseri, A. (2002) Inflammation and atherosclerosis. Circulation, 105(9), 1135-1143.
[20] Topol, E. (2005) Atlas of Atherothrombosis. Current Medical Group. 2004 London.
[21] Gawaz, M. (2006) The evolving science of atherothrom-botic disease Eur heart J Suppl. Antiplateled Strategies in Patients Undergoing Interventions with Acute Coronary Syndrome Ed. J.-F. Neumann, 10(1), 14-17.
[22] Solem, J., Levin, M., Karlsson, T., Grip, L., Albertson, P., Wiklund, O. (2006) Composition of coronary plaque ob-tained by directional atherectomy in stable angina: its re-lation to serum lipids and statin treatment. J Int Med, 259 (3), 267-275.
[23] Tanaka, A., Shimada, K., Numba, M., Sakamoto, T., Na-kamura, Y., Nishida, V.Y., Yoshikawa, J., Akasaka, T.M., Relationship between longitudinal.
[24] (2008) Morphology of ruptured plaques and TIMI flow grade in acute coronary syndrome: a three-dimensional intravascular ultrasound imaging study. Eur Heart J, 29, 38-44.
[25] De Catherina, R., Husted, S., Walentin, L. et al. (2007) ESC position paper v. Anticoagulants in heart disease: current status and perspectives. Eur Heart J, 28(7), 880-913.
[26] Thigesen, K., Alpert, J.S. (2007) White HD on behalf the ESC/ACCF/AHA/ WHF task force universal definition of myocardial infarction. European Heart Journal, 28, 2525-2538.
[27] Stoupel, E. (2002) The effect of geomagnetic activity on cardiovascular parameters. Biomedicine & Pharmaco-therapy. 56, 247-256.
[28] Stoupel, E., Domarkiene, S., Radishauskas, R., Abramson, E., Israelevich, P., Sulkes, J. (2006) Neutrons and Sudden Cardiac Deaths (SCD) Codes 121-125 ICD 10. Basic & Clin Physiol & Pharmacol, 17(1), 45-53.
[29] Stoupel, E., Assali, A., Teplitzky, I., Abramson, E., Is-raelevich, P., Sulkes, J. (2008) The culprit artery in acute myocardial infarction in different environmental physical activity levels. Intern J Cardiol, 126, 266-290.
[30] Stoupel, E., Kusniec, J., Mazur, J., Abramson, E., Is-raelevich, P., Strasberg, B. (2008) Timing of life-threat-ening arrhythmias detected by implantable cardioverter- defibrillators in relation to changes in cosmophysical factors. Cardiology J, 15(5), 1-4.
[31] Stoupel, E., Assali, A., Teplitzky, I., Vaknin-Assa, H., Abramson, E., Israelevich, P., Kornowski, R. (2009) Physical influences on right ventricular infarction and cardiogenic shock in acute myocardial Infarction. Basic & Clin Physiol & Pharmacol, 20(1), 83-90.
[32] Stoupel, E., Kalediene, R., Petrauskiene, J., Starkuviene, S., Abramson, E., Israelevich, P., Sulkes, J. (2009) Death- optimal physical conditions. The 56th Annual Conference of the Israeli Heart Society, Program and Abstracts. 119, 16.
[33] Stoupel, E., Babayev, E., Mustafa, F., Abramson, E., Israelevich, P., Sulkes, J. (2003-2005) (2006) Clinical cosmobiology: Sudden cardiac death and daily /monthly geomagnetic-cosmic ray and solar activity. The Baku Study. Sun & Geosphere, 1(2), 13-16.
[34] Kirby, A.J., Hollffelder, F. (2008) Enzymes under the nanoscope. Nature, 456(6), 45-47.
[35] Nias, A.H.V. (1999) An introroduction to radiotherapy. John Wiley & Sons, NY.
[36] The Pierre Auger collaboration. (2007) Correlation of the Highest–Energy Cosmic Rays with Nearby Extragalactic Objects, Science, 318(5852), 938-943.
[37] Johnston, H. (2008) Cosmic-ray mystery solved at last., 31764, 1-3.
[38] Cho, A. (2007) Universe's Highest-Energy Particles Traced Back to Other Galaxies Science, 318, 896-897. (Accessed December 24).

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.