Comparative Efficacy of Tagetes erecta and Centella asiatica Extracts on Wound Healing in Albino Rats

Sandipan Chatterjee, Tigari Prakash, Dupadahalli Kotrsha, Nadendla Rama Rao, Divakar Goli

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DOI: 10.4236/cm.2011.24023                

Abstract

The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Tagetes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead space wound models in albino rats. Extract of T. erecta and C. asiatica (P < 0.001) showed significant increase in rate of wound contraction, epithelization and formation of scar faster in excision wound model compare to control group. T. erecta extract (250 and 500 mg/kg) showed significantly increased the wound breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a dead space wound model compare to control and C. asiatica treated group (P < 0.001). In this investigation the work is conclude that the comparison made between the above two plants, the T. erecta extract showed potent wound healing activity then the reported C. asiatica in different wound parameters.

Keywords

Centella asiatica, Tagetes erecta , Excision, Incision, Dead Space Wound Model

Conflicts of Interest

The authors declare no conflicts of interest.

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