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A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles

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DOI: 10.4236/jbnb.2011.24056    4,078 Downloads   7,185 Views   Citations

ABSTRACT

Au-nanoparticles (size about 2 nm, but not 5 or 15 nm) are capable of effectively incorporating into quasinematic layers of particles of cholesteric liquid-crystalline dispersion formed by double-stranded nucleic acid molecules of various families (DNA and poly(I)xpoly(C)). This Au-size-dependent process is accompanied by a decrease in amplitudes of abnormal bands in the CD spectra specific to initial cholesteric liquid-crystalline dispersions and simultaneously by an appearance of plasmon resonance band in visible absorption spectrum. The study of properties of particles of cholesteric liquid-crystalline dispersion treated with Au-nanoparticles by means of various physico-chemical methods demonstrates that incorporation of Au-nanoparticles into quasinematic layers of these particles results in two effects: i) it facilitates reorganization of the spatial cholesteric structure of particles, and ii) it induces the formation of Au-clusters in the content of particles. It is not excluded that these effects represent a possible reason for genotoxicity of Au-nanopar- ticles.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Y. Yevdokimov, S. Skuridin, V. Salyanov, V. Popenko, V. Rudoy, O. Dement′eva and E. Shtykova, "A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 4, 2011, pp. 461-471. doi: 10.4236/jbnb.2011.24056.

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