One-month immunotherapy trial in treatment-failed TB patients


reatment failed TB patients have very limited chances of survival. Open label trial of daily oral pill of V-5 Immunitor (V5) was conducted in 48 treatment-failed TB patients on palliative support consisting of isoniazid (H) and rifampicin (R). The subjects had the following forms of TB; cavitary: disseminated: MDR-TB: DR-TB: TB/HIV at 35:13:7:4:1 ratio. After 1 month 62.5% of V5-treated patients experienced negative sputum smear conversion (P < 0.0001), comprising 11 out of 12 (91.7%) converted among those who had drug-resistant TB and TB/HIV. TB-associated inflammation was downregulated as evidenced by normalization of leukocytosis 7.4 vs. 6.7 x 109 L (P = 0.01) and decreased erythrocyte sedimentation rate 20.5 vs. 14.9 mm/h (P < 0.0001). The mean body temperature normalized from 37.25° ± 0.6° to 36.98° ± 0.4° (P = 0.0002). The average body weight gain and body mass index (BMI) increased by 0.8 ± 0.7 kg and from 18.9 to 19.6 kg/m2 respectively (P < 0.0001). Two patients (4.2%) died from illicit drug- and alcohol-abuse related causes. No adverse effects or reactivation of disease due to immune intervention were seen at any time. V5 is safe and in combination with a simple two-drug regimen was highly effective as an immune adjunct to produce favorable outcome among treatment-failed and/ or drug-resistant TB patients.

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Arjanova, O. , Butov, D. , Prihoda, N. , Zaitzeva, S. , Yurchenko, L. , Sokolenko, N. , Stepanenko, A. , Butova, T. , Grinishina, E. , Maksimenko, O. , Jirathitikal, V. , Bourinbaiar, A. , Frolov, V. and Kutsyna, G. (2011) One-month immunotherapy trial in treatment-failed TB patients. Open Journal of Immunology, 1, 50-55. doi: 10.4236/oji.2011.12006.

Conflicts of Interest

The authors declare no conflicts of interest.


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