Metastatic Secondary Anaplastic Meningioma

DOI: 10.4236/oalib.1103170   PDF   HTML   XML   856 Downloads   2,055 Views  


Usually, meningiomas are benign neoplasms and their malignant behavior is limited to local recurrence and brain invasion. The rate of local recurrence increases according to histological grade as reported by WHO criteria while extracranial metastases are rare. Anaplastic meningiomas (AM) represent the most rare and aggressive subtype of all meningiomas. This tumor may progress from lower grade I or II meningiomas (secondary AM) or develops as de novo disease (primary AM). We report a case of extracranial metastatic progression of a heavily treated intracranial secondary anaplastic meningioma. The metastatic progression was detected as unexpected and unsuspected diagnosis because it occurred in absence of local intracranial recurrence. There are no criteria to evaluate the risk for the metastatic spread. In hindsight, a malignant progression in tumor histological grade and a significant increase of ki-67 index represent useful predictors of the aggressive behavior.

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Santorsa, L. , Lorusso, F. , Divella, R. , Gentile, A. , Mazzocca, A. , Fazio, P. , Troiani, L. , Lotesoriere, C. , Campanella, G. , Bagnoli, J. and Lolli, I. (2016) Metastatic Secondary Anaplastic Meningioma. Open Access Library Journal, 3, 1-6. doi: 10.4236/oalib.1103170.

1. Introduction

Meningiomas arise from arachnoidal cells of the leptomeninges and account for 13% - 26% of all primary brain tumors in adults [1] . Although most meningiomas are considered to be slow-growing lesions, they present histologically distinct subsets associated with different risks of local recurrence, even after macroscopically complete excision. According to the World Health Organization (WHO) criteria, there are three grades of histologic subtypes of meningiomas with different aggressiveness. About 90% of all meningiomas are grade I and show pleomorphic features and occasional mitotic figures. This category, usually defined as benign, presents a local recurrence rate between 7% and 20%. The rest is classified as atypical (grade II) or anaplastic (grade III) tumors. Atypical meningiomas (4.7% - 7.2%) present histological aspect of malignancy with an increased mitotic ratio defined as ≥4 mitoses/10 high power fields (HPF). These tumors display a more aggressive clinical behaviour and have a recurrence rate ranging between 30% and 40%. Anaplastic meningiomas (AM-WHO-III˚) represent the rarest (1% - 3% of cases) and the most aggressive subtype with poor prognosis and recurrence rates as high as 50% - 78%. These tumors show frank malignant features with a high mitotic index (≥20 mitoses/10 HPF). They may progress from low-grade meningiomas (secondary AM-WHO-III˚) or develop as de novo disease, primary AM-WHO-III˚ [2] . If we consider all grades meningiomas, the incidence of metastases is very low and the risk of metastatic spread increases along with higher grades. An intracranial meningioma usually recurs locally several times before it metastasizes. Here, we report a rare case of a heavily treated intracranial secondary AM-WHO-III˚ with subsequent massive extracranial metastases. The reported case is unusual because the patient’s meningioma showed an aggressive behavior after first surgery and adjuvant radiotherapy with a documented rapid malignant progression in histological grade from an atypical to an aggressive form with a poorly differentiated phenotype. Initially it was classified as atypical while the recurrent tumor resulted anaplastic at second surgery. Moreover, the secondary AM-WHO-III˚ spread widely and metastasized pleura, liver and lymph nodes in absence of intracranial progression.

2. Case Report

A 56-year-old man was admitted to hospital for clinical evaluation for headache and mild anomic aphasia. The patient’s medical history was unremarkable. Magnetic resonance imaging (MRI) was carried out and showed a large solid enhancing extra axial tumor with significant mass effect localized in the left frontal lobe (Figure 1(A)). A macroscopically total surgical resection of tumor was performed. Histopathologic examination revealed a monotonous proliferation of spindle cells with high nucleus/cy- toplasmic ratio and prominent nucleoli, displaying a mitotic activity with about 6 mitosis/10HPF and rare foci of necrosis. Immunoistochemistry showed epithelial membrane antigen (EMA) positivity, absence of cytokeratine immunoreactivity and proliferation index (Ki67: 10%) consistent with diagnosis of atypical meningioma. The patient was referred to adjuvant radiotherapy for a 60 Gy total dose over 30 fractions. Three months after radiotherapy treatment, the patient presented slight aphasia, moderate right hemiparesis and dysgraphia. A new radiological examination revealed recurrence on the previous surgical site (Figure 1(B)). Therefore, a second surgery with total resection of the tumor was done. Histopathologic examination revealed massive proli-

Figure 1. Magnetic resonance imaging (MRI) and 111 Inpenteotride octreoscan (A); enhancing extra-axial tumor in left frontal lobe (baseline); (B) disease recurrence at surgical site; (C) high focal uptake in the left frontal lobe; (D) no other uptake areas in the body.

feration of spindle cells with nuclear pleomorphism displaying areas of necrosis, brain parenchymal invasion and a mitotic rate up to 20 mitosis/10 HPF. Immunohistochemical staining showed expression of EMA positivity and marked proliferative activity (Ki67 > 30%). The tumor cells lacked expression for glial fibrillary acidic protein (GFAP), S-100 protein, Melan-A and CAM 5.2. These pathologic findings were consistent with the diagnosis of anaplastic meningioma and revealed a dedifferentiation of the tumor to a WHO grade III. The patient recovered well with minimal neurologic sequelae. Six months later in a follow-up MRI scan, the patient was diagnosed with a recurrence. After two cycles of chemotherapy with temozolomide (TMZ; Temodal; Merck; whitehouse Station, NJ) at a standard dose (200 mg/m2 for 5 days, every 28 days), an indium-111-penteotride scintigraphy scan (Octreoscan; Covidien, Mansfield, MA) showed high, focal radionuclide tracer uptake in the left frontal lobe (Figure 1(C)) and an absence of other avid 111-In-penteotride uptake areas in the body (Figure 1(D)). Repeat surgery was evaluated as inappropriate and the patient underwent Cyberknife hypofractionated stereotactic radiosurgery (SRS). This treatment was followed by a therapy with antiangiogenic antibody bevacizumab (10 mg/kg every 2 weeks) and octreotide acetate Long-Acting-Release (30mg every month) on the basis of Octreoscan results. One year later the SRS treatment and the start of target therapy, the patient complained mild pain on thorax right side with slight dyspnea. A computed tomography (CT) scan revealed a stable intracranial disease (Figure 2(A)), an extensive thickening of the right parietal pleura (Figure 2(B)), massive abdominal lymph nodes enlargement, and metastases in both hepatic lobes (Figure 2(C)). A fine needle aspiration biopsy (FNAB) of the pleural lesion resulted not diagnostic. An ultrasound guided core

Figure 2. Computed Tomography (CT) and histological features of liver metastasis of anaplastic meningioma. (A) stable intracranial disease; (B) extensive right parietal pleural thickening; (C) metastases of both hepatic lobes; (D) spindle cell tumors with clear cells aspects.

biopsy of a hepatic mass revealed histologic features of spindle cell tumor with clear cells aspects (Figure 2(D)). Immunohistochemistry demonstrated EMA and Vimentin positivity and a Ki67 index of 30%. The tumor cells lacked expression for GFAP, S-100 protein, Melan-A, anti-Melanoma CD56, DOG-1, TTF1, CD117, Synaptophisin, CK8/18, CKAE1-AE3, Progesterone receptor (PR) and CEA. These pathologic findings were consistent with the diagnosis of liver metastasis of AM-WHO-III°. In agreement with the patient and his relatives, treatment was halted and the patient was referred to supportive care. Notwithstanding appropriate care, the patient passed away 33 months after the first operation.

3. Discussion

Complete surgical excision is the treatment of choice for all resectable meningioma tumors. Postoperative radiotherapy is recommended to prevent local recurrence, especially in cases of partial resection or when histology suggests malignancy. The role of chemotherapy, as monotherapy or combination regimens, is limited to tumors that show no or minimal consistent response to radiotherapy. The management for recurrent meningioma includes second surgery, radiotherapy and stereotactic radiosurgery. Meningiomas are vascularized tumors and this represents the reason for the use of antiangiogenic therapy with bevacizumab [3] . 111-Indium labeled octreotide brain scintigraphy can be used to delineate disease extent and to select patients with inoperable recurrence refractory to radiotherapy who are likely to respond to somatostatin analogues therapy [4] . In fact, somatostatin receptors (SR) are present on most meningiomas. Only 0.1% - 0.2% of all intracranial meningiomas metastasize outside the central nervous system with the lungs as preferred site [5] . Metastases other than pulmonary are rarely reported in the literature but they may occur in intra-abdominal organs, lymph nodes, bone, and muscle [6] [7] . Recurrent tumors with malignant histological features and a history of repeated surgical resections are associated with a higher risk of extracranial metastases [8] . In spite of this, a systemic workup for distant metastases is usually not included in the evaluation paradigm for patients with high-risk recurrent meningioma. The current case was a massive extracranial dissemination of an intracranial secondary AM-WHO-III˚ and revealed as an unexpected diagnosis because of mild clinical signs without local intracranial progression. In our patient, the malignant progression according to the WHO grade, from atypical to anaplastic phenotype, was characterized by histological aspects of frank malignancy of the recurrent tumor and by a significant increase of the Ki-67 index (from 10% in the original tumor to 30% in the recurrence) [9] . The increase of the Ki-67 index showed a good correlation with the histological grade and the tendency of the tumor to recur and metastasize [10] . According to this report, a multivisceral metastatic spread may occur in absence of intracranial progression. Therefore it should be taken into account in the patient’s follow-up that extracranial metastatic process in AM-WHO-III˚ is not necessarily linked to intracranial relapse.

4. Conclusion

The histological grade and the Ki-67 index are the most predictive factors for both recurrence and extracranial metastases in secondary AM-WHO-III˚. These tumors are difficult to manage. Chemotherapy, radiotherapy and surgery have all been described and remain under study although none of these treatments has managed to achieve more than a partial response [11] . At recurrence, there is no consensus on treatment options. In our case, two cycles of short-term treatment with the cytotoxic agent temozolomide were not long enough to show effectiveness while SRS was effective to control local tumor. Conversely, target therapy with bevacizumab and octreotide acetate LAR showed disappointing results in the metastatic spread control.

Conflict of Interest

All authors have no financial or others conflict to declare.

Author’s Contributions

All authors contributed equally to this work, and all authors read and approved the final manuscript.

Statement of Ethics

Written informed consent was obtained from the patient’s relative (son) for publication of this case report and any accompanying images.

Conflicts of Interest

The authors declare no conflicts of interest.


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