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A Retroperitoneal Inflammatory Myofibroblastic Tumor Mimicking a Germ Cell Tumor of the Undescended Testis: A Case Report and Literature Review

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DOI: 10.4236/act.2016.53004    1,039 Downloads   1,502 Views  

ABSTRACT

We report here a case of an inflammatory myofibroblastic tumor in the retroperitoneum, which mimicked a germ cell tumor of the undescended testis. A 75-year-old healthy man presented with a palpable abdominal mass. On the computed tomography image, there was large, well-defined soft tissue mass in the left side of the retroperitoneum, and there was no visible left testis or seminal vesicle. After contrast enhancement, the mass appeared to be relatively homogeneous, considering its large size. With ultrasonography, it appeared as a well-defined, hypoechoic mass with intratumoral vascularity. This solid mass was surgically diagnosed as an inflammatory myofibroblastic tumor.

1. Introduction

An Inflammatory Myofibroblastic Tumor (IMT), also well known as an inflammatory pseudotumor, is a rare benign lesion of unknown etiology. It usually affects children and young adults and commonly involves the lung and orbit. Approximately 17 cases of retroperitoneal IMT were reported in the English literature. Furthermore, case reports containing imaging of retroperitoneal IMT were even rarer, to our knowledge. Here, we describe the radiologic findings from Computed Tomography (CT) and ultrasonography (US) of a case of retroperitoneal IMT, which mimicked a germ cell tumor arising from the undescended testis in a 75-year-old man.

2. Case Report

A 75-year-old previously healthy man presented with a palpable abdominal mass and weight loss. The patient did not have any special medical history. His physical examination was normal except for the palpable abdominal mass. Laboratory tests revealed mild anemia (Hgb 9.9 g/dl, normal range 14 - 18) and markedly increased C-Reactive protein (13.19, normal range 0 - 0.05). On a contrast-enhanced abdominopelvic CT, a 6.3 × 9.5 × 9.5 cm, well-defined isodense mass with a small internal cystic or necrotic portion was detected in the left retroperitoneum, abutting the left psoas muscle. The mass showed gradual enhancement and contained relatively homogeneous mass parenchyma despite its large size (Figure 1). The kidney could be visualized in the left renal fossa, but the left testis and seminal vesicle were not visible in the left scrotal sac (Figure 1(c) and Figure 1(e)). This finding indicated either incomplete descent or agenesis of the left testis. In the clinic, a malignant germ cell tumor, especially a germ cell tumor arising from the undescended left testis, was included in the first differential diagnosis, but laboratory results of b-human chorionic gonadotropin, alpha-fetoprotein, prostate- specific antigen were all within normal limit. Then, the patient underwent an US- guided needle biopsy. The sonographic findings included a slightly hypoechoic solid mass with an internal small cystic portion at the time of biopsy (Figure 2(a)). Color Doppler imaging revealed intratumoral hypervascularity (Figure 2(b)). The biopsy specimen contained an aggregation of mixed inflammatory cells, including neutrophils, plasma cells and foamy histiocytes. The results of the CK (cytokeratins) and C-kit immunohistochemistry were negative. The results of biopsy were unsatisfactory with the risk of malignancy, especially considering the patient’s age. Therefore, we followed up after 1 month with US. The follow-up US showed that the retroperitoneal mass increased in size from 8 × 7 cm to 9 × 8.7 cm. Eventually, the patient underwent transperitoneal laparoscopic excision of the left retroperitoneal tumor. Gross examination showed a well-circumscribed, multinodular solid mass of yellow gray color with some cystic change. Microscopic examination showed proliferation of myofibroblasts with mixed inflammatory cell infiltration (Figure 3). Mitotic activity was low, and cellular atypism was minimal. Immunohistochemical staining was negative for S100, epithelial membrane antigen, CK, desmin and ALK (anaplastic lymphoma kinase) but positive for smooth muscle actin and cluster of differentiation 34. These findings were consistent with IMT.

3. Discussion

IMT has been reported in various sites in the abdomen, including the liver, spleen, pancreas, adrenal gland, kidney, retroperitoneum, mesentery, gastrointestinal and urinary tract [1] [2] [3] [4] [5] . It most commonly affects children and young adults and frequently occurs in the lungs [2] . Extrapulmonary IMT accounts for approximately 5%

(a) (b) (c) (d) (e)

Figure 1. A 75-year-old man with an incidental finding of a left retroperitoneal inflammatory myofibroblastic tumor ((a)-(e)). Axial CT images at the unenhanced (a), the arterial phase ((b), (c)) and a coronal reconstructive image at the portal phase ((d), (e)) show a well-defined and well-enhanced mass with an internal cystic or necrotic portion (arrow) in the left retroperitoneum, abutting the left psoas muscle (arrowhead at (b)). It shows consistent enhancement at the delayed phase (not shown). There is no visible spermatic cord or seminal vesicle (arrow at (c)), or left testis (e).

of IMT [6] . Retroperitoneal involvement is rare in extrapulmonary IMT. Coffen et al. conducted a clinicopathologic study of 84 cases of extrapulmonary IMT, including 4 cases of retroperitoneal IMT [7] . The patients often presented with features of inflammation, such as fever and weight loss. Laboratory abnormalities also included the stigma of inflammation, such as the hypochromic microcytic anemia in our patient.

The differential diagnosis for a retroperitoneal solid mass includes both neoplastic and nonneoplastic entities. Nonneoplastic entities include retroperitoneal fibrosis and

(a) (b)

Figure 2. Grey scale US (a) shows an oval shaped, slightly hypoechoic solid mass with an internal small cystic portion in the left retroperitoneum. Color Doppler US (b) reveals intratumoralhypervascularity.

(a) (b)

Figure 3. Photomicrograph of a histological specimen shows proliferation of myofibroblasts with mixed inflammatory cell infiltration (including neutrophils, plasma cells and foamy histiocytes), low mitotic activity and minimal cellular atypism (hematoxylin-eosin stain, original magnification ×400 (a) and ×1000 (b)).

extramedullary hematopoiesis, which, on occasion, can produce bulky masses. The large size, well-defined contour and relatively homogenous enhancement of the mass in our case made these diagnoses unlikely. Neoplastic entities can have mesodermal origins, neurogenic origins, lymphoid or hematologic origins, and germ cell, sex cord, and stromal cell origins. Of these neoplastic entities, primary retroperitoneal tumors including malignant fibrous histiocytoma, leiomyosarcoma show usually large infiltrating, heterogeneously enhancing soft tissue mass containing extensive necrosis or hemorrhage. Neurogenic tumors show large heterogeneous appearance usually located at paravertebral region. Differential diagnosis may be helpful for addressing the overlap in the imaging findings of many of these masses. Lymphoma and metastatic lymphadenopathy are two of the most common soft-tissue masses observed in the retroperitoneum and should always be considered. However, in this case, there was no visible testis or seminal vesicle in the left scrotal sac, which suggested the possibility of an undescended testis. So, our first impression was that the mass was a germ cell tumor arising from the undescended testis. It could also be classified as a huge retroperitoneal mass with nonspecific radiologic findings.

IMT is a rare benign condition which mimics malignancy both clinically and radiologically. The definitive diagnosis is based on histological evaluation of tissue specimens characterized by proliferative myofibroblasts or fibroblasts with inflammatory cell infiltration, such as histiocytes, plasma cells and lymphocytes [1] . This tumor was previously described as an inflammatory pseudotumor, inflammatory myofibroblastoma, lymphoplasmacytic histiocytoma, and fibrous pseudotumor until 1994, when IMT was established as a distinct low-grade malignancy by the World Health Organization [2] . Usually, IMT has a benign course, and in most cases, it is a slow growing, locally confined tumor with less metastatic potential [3] . The histogenesis of IMT is uncertain, but it is generally thought to arise as the result of an inflammatory reaction to surgery, trauma, malignancy, infection by the Epstein-Barr virus or the Human Herpes virus [4] . Others have insisted that a chromosomal rearrangement involving the ALK gene results in the activation of a tyrosine kinase receptor that could lead to abnormal expression [5] .

The nonspecific radiologic findings of IMT in other locations have been reported in the literature. Contrast enhanced CT may show variable density with homogenous or heterogeneous masses. Larger lesions may have central necrosis. There are varying degrees and patterns of contrast enhancement [8] [9] . US also obtains variable patterns of echogenicity with ill-defined or well-circumscribed margins, while Doppler may reveal prominent vascular flow [9] . On magnetic resonance images, the appearance of these tumors is also variable. They are usually hypointense relative to skeletal muscle on T1- weighted images, hyperintense on T2-weighted images and heterogeneously enhanced after administration of contrast material [10] . These variable radiologic findings may be attributed to histologic complexity with the duration of the disease process, the amount of fibrous tissue and the degree of cellular infiltration. Generally, IMT has an innocuous clinical course, despite its variable biological potential. Complete surgical resection is the treatment of choice for most IMTs, with the exception of orbital lesions. Treatment of orbital IMT usually begins with high doses of systemic steroids. Approximately 50% of orbital IMT cases resolve completely with steroid treatment. Antibiotics have also been used in some cases. Additionally, several cases of spontaneous regression have been reported. Radiation therapy has been attempted in unresectable cases and when cases have poor responses to steroid therapy. In summary, we reported a case of IMT, an extremely rare quasi-neoplastic retroperitoneal mass, which was first suspected to be a germ cell tumor arising from the undescended testis. Differentiation from malignant retroperitoneal neoplasm was not possible preoperatively. Fine-needle biopsy may fail to yield a sufficient volume of tumor tissue to make a definite diagnosis. Retroperitoneal IMTs are rare presentations of a rare disease. Although they are unlikely to occur in the retroperitoneum, IMTs should be kept in mind as a possibility.

Abbreviations

IMT: inflammatory myofibroblastic tumor.

CT: computed tomography.

US: ultrasonography.

CK: cytokeratins.

ALK: anaplastic lymphoma kinase.

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Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Lee, S. , Yoon, J. , Kim, S. , Lee, Y. , Lee, J. and Seo, J. (2016) A Retroperitoneal Inflammatory Myofibroblastic Tumor Mimicking a Germ Cell Tumor of the Undescended Testis: A Case Report and Literature Review. Advances in Computed Tomography, 5, 35-41. doi: 10.4236/act.2016.53004.

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