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Effects of Mixed Dietary Fats on the Distribution of Triglycerides in Different Tissues of Exercised Trained Swiss Albino Mice

DOI: 10.4236/oalib.1102113    541 Downloads   770 Views  

ABSTRACT

During prolonged exercise, fatty acids are mobilized from triglycerides (TG) and become an important energy source. But excess accumulation of TG in different tissues causes abnormalities in humans. Role of high fat diet in the distribution of TG is well established but the role of mixed dietary fat is not clear. In our study, exercised Swiss Albino mice were subjected to feed high fat diet and mixed fat diet (Saturated Unsaturated fat enriched diet) for the period of four weeks to show the effect on average body weight, liver, adipose tissue and gastrocnemius muscles and the accumulation of their triglycerides (TG) content. This study showed that both diets had little or no effect on average body weight, epididymal adipose tissue weight and liver TG but decreased liver weight. Here another remarkable feature was that high fat diet significantly reduced the accumulation of TG in epididymal adipose tissue in comparison with mixed fat diet. The author demonstrated that mixed fat diet induced accumulation of TG in gastrocnemius skeletal muscles of exercised mice but decreased gastrocnemius skeletal muscles weight. Further research is required to clarify these phenomena.

Conflicts of Interest

The authors declare no conflicts of interest.

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Rahman, S. , Ali, M. and Rahman, M. (2015) Effects of Mixed Dietary Fats on the Distribution of Triglycerides in Different Tissues of Exercised Trained Swiss Albino Mice. Open Access Library Journal, 2, 1-8. doi: 10.4236/oalib.1102113.

References

[1] Kiens, B. (2006) Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance. Physiological Reviews, 86, 205-243.
http://dx.doi.org/10.1152/physrev.00023.2004
[2] Spriet, L.L. and Watt, M.J. (2003) Regulatory Mechanisms in the Interaction between Carbohydrate and Lipid Oxidation during Exercise. Acta Physiologica Scandinavica, 178, 443-452.
http://dx.doi.org/10.1046/j.1365-201X.2003.01152.x
[3] Piscitelli, F., Carta, G., Bisogno, T., Murru, E. and Cordeddu, L. (2011) Effect of Dietary Krill Oil Supplementation on the Endocannabinoidome of Metabolically Relevant Tissues from High Fat-Fed Mice. Nutrition & Metabolism, 8, 51.
http://dx.doi.org/10.1186/1743-7075-8-51
[4] Tandy, S., Chung, R.W., Wat, E., Kamili, A. and Berge, K. (2009) Dietary Krill Oil Supplementation Reduces Hepatic Steatosis, Glycemia, and Hypercholesterolemia in High-Fat-Fed Mice. Journal of Agricultural and Food Chemistry, 57, 9339-9345.
http://dx.doi.org/10.1021/jf9016042
[5] Bracco, E.F., Torbay, N., Geiebter, A., Stewart, I., Seylar, J. and Hashim, S.A. (1980) Insulin Increases Body Fat with Control of Food Intake and Physical Activity. Alimentary Nutrition & Metabolism, l, 234.
[6] Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets. Journal of Clinical Investigation, 118, 2808-2821.
[7] Hotamisligil, G.S., Budavari, A., Murray, D. and Spiegelman, B.M. (1994) Reduced Tyrosine Kinase Activity of the Insulin Receptor in Obesity-Diabetes: Central Role of Tumor Necrosis Factor-Alpha. Journal of Clinical Investigation, 94, 1543-1549.
http://dx.doi.org/10.1172/JCI117495
[8] Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993) Adipose Expression of Tumor Necrosis Factor-Alpha: Direct Role in Obesity-Linked Insulin Resistance. Science, 259, 87-91.
http://dx.doi.org/10.1126/science.7678183
[9] Dobbins, R.L., Szczepaniak, L.S., Bentley, B., Esser, V., Myhill, J. and McGarry, J.D. (2001) Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats. Diabetes, 50, 123-130.
http://dx.doi.org/10.2337/diabetes.50.1.123
[10] Kim, J.K., Gavrilova, O., Chen, Y., Reitman, M.L. and Shulman, G.I. (2000) Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice. Journal of Biological Chemistry, 275, 8456-8460.
http://dx.doi.org/10.1074/jbc.275.12.8456
[11] Shulman, G.I. (2000) Cellular Mechanisms of Insulin Resistance. Journal of Clinical Investigation, 106, 171-176.
http://dx.doi.org/10.1172/JCI10583
[12] Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A. and Luzi, L. (1999) Intramyocellular Triglyceride Content Is a Determinant of in Vivo Insulin Resistance in Humans: A 1H-13C Nuclear Magnetic Resonance Spectroscopy Assessment in Offspring of Type 2 Diabetic Parents. Diabetes, 48, 1600-1606.
http://dx.doi.org/10.2337/diabetes.48.8.1600
[13] Pan, D.A., Lillioja, S., Kriketos, A.D., Milner, M.R., Baur, L.A., Bogardus, C., Jenkins, A.B. and Storlien, L.H. (1997) Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action. Diabetes, 46, 983-988.
http://dx.doi.org/10.2337/diab.46.6.983
[14] Kunesova, M., Braunerova, R., Hlavaty, P., Tvrzicka, E. and Stankova, B. (2006) The Influence of n-3 Polyunsaturated Fatty Acids and Very Low Calorie Diet during a Short-Term Weight Reducing Regimen on Weight Loss and Serum Fatty Acid Composition in Severely Obese Women. Physiological Research, 55, 63-72.
[15] Mori, T.A., Bao, D.Q., Burke, V., Puddey, I.B. and Watts, G.F. (1999) Dietary Fish as a Major Component of a Weight-Loss Diet: Effect on Serum Lipids, Glucose, and Insulin Metabolism in Overweight Hypertensive Subjects. The American Journal of Clinical Nutrition, 70, 817-825.
[16] Flachs, P., Mohamed-Ali, V., Horakova, O., Rossmeisl, M. and Hosseinzadeh-Attar, M.J. (2006) Polyunsaturated Fatty Acids of Marine Origin Induce Adiponectin in Mice Fed High-Fat Diet. Diabetologia, 49, 394-397.
http://dx.doi.org/10.1007/s00125-005-0053-y
[17] Rustan, A.C., Christiansen, E.N. and Drevon, C.A. (1992) Serum Lipids, Hepatic Glycerolipid Metabolism and Peroxisomal Fatty Acid Oxidation in Rats Fed Omega-3 and Omega-6 Fatty Acids. Biochemical Journal, 283, 333-339.
http://dx.doi.org/10.1042/bj2830333
[18] Rossmeisl, M., Macek Jilkova, Z., Kuda, O., Jelenik, T., Medrikova, D., et al. (2012) Metabolic Effects of n-3 PUFA as Phospholipids Are Superior to Triglycerides in Mice Fed a High-Fat Diet: Possible Role of Endocannabinoids. PLoS ONE, 7, e38834.
http://dx.doi.org/10.1371/journal.pone.0038834
[19] Lavau, M.M. and Hashim, S.A. (1978) Effect of Medium Chain Triglyceride on Lipogenesis and Body Fat in the Rat. Journal of Nutrition, 108, 613-620.
[20] Wiley, J.H. and Leveille, G.A. (1973) Metabolic Consequences of Dietary Medium Chain Triglycerides in the Rat. Journal of Nutrition, 103, 829-835.
[21] Harkins, R.W. and Sarett, H.P. (1968) Nutritional Evaluation of Medium-Chain Triglycerides in the Rat. Journal of the American Oil Chemists’ Society, 45, 26-30.
http://dx.doi.org/10.1007/BF02679041
[22] Kaunitz, H., Slanetz, C.A., Johnson, R.E., Babayan, V.K. and Barsky, G. (1958) Relation of Saturated, Medium- and Longchain Triglycerides to Growth, Appetite, Thirst and Weight Maintenance Requirements. Journal of Nutrition, 64, 13-24.
[23] Harris, R.B. (1994) Factors Influencing Energy Intake of Rats Fed either a High-Fat or a Fat Mimetic Diet. International Journal of Obesity and Related Metabolic Disorders, 18, 632-640.
[24] Altunkaynak, Z. (2005) Effects of High Fat Diet Induced Obesity on Female Rat Livers (a Histological Study). European Journal of General Medicine, 2, 100-109.
[25] Straczkowski, M., Kowalska, I., Dzienis-Straczkowska, S., Kinalski, M., Górski, J. and Kinalska, I. (2001) The Effect of Exercise Training on Glucose Tolerance and Skeletal Muscle Triacylglycerol Content in Rats Fed with a High-Fat Diet. Diabetes & Metabolism, 27, 19-23.
[26] Yasari, S., Paquette, A., Charbonneau, A., Gauthier, M.S., Savard, R. and Lavoie, J.M. (2006) Effects of Ingesting a High-Fat Diet upon Exercise-Training Cease Fat Accretion in the Liver and Adipose Tissue of Rats. Applied Physiology, Nutrition, and Metabolism, 31, 367-375.
http://dx.doi.org/10.1139/h06-032
[27] Yasari, S., Dufresne, E., Prud’homme, D. and Lavoie, J.M. (2007) Effect of the Detraining Status on High-Fat Diet Induced Fat Accumulation in the Adipose Tissue and Liver in Female Rats. Physiology & Behavior, 91, 281-289.
http://dx.doi.org/10.1016/j.physbeh.2007.03.012
[28] Horowitz, J.F. and Klein, S. (2000) Lipid Metabolism during Endurance Exercise1,2,3. The American Journal of Clinical Nutrition, 72, 558S-563S.
[29] Katsanos, C.S. (2004) Lipid-Induced Insulin Resistance in the Liver: Role of Exercise. Sports Medicine, 34, 955-965.
http://dx.doi.org/10.2165/00007256-200434140-00002
[30] Schenk, S. and Horowitz, J.F. (2007) Acute Exercise Increases Triglyceride Synthesis in Skeletal Muscle and Prevents Fatty Acid-Induced Insulin Resistance. Journal of Clinical Investigation, 117, 1690-1698.
http://dx.doi.org/10.1172/JCI30566
[31] Corcoran, M.P., Lamon-Fava, S. and Fielding, R.A. (2007) Skeletal Muscle Lipid Deposition and Insulin Resistance: Effect of Dietary Fatty Acids and Exercise1,2,3. The American Journal of Clinical Nutrition, 85, 662-677.

  
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