The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study

Gordon H. Sasaki

doi:10.4236/oalib.1101867

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Open Access Library Journal > Vol.2 No.10, October 2015

The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study ()

Gordon H. Sasaki

Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, USA.

DOI: 10.4236/oalib.1101867 PDF HTML XML 1,222 Downloads 1,606 Views Citations

Abstract

Background: Human growth factors serve as secretomes that regulate skin cell proliferation/differentiation and production of extracellular elements of the matrix and treat photo-aging. Microneedling of skin can also improve aging skin by facilitating normal wound healing of the temporary dermal conduits for therapeutic and cosmetic benefits. Objectives: This open, randomized split-face and single-center controlled study evaluated the safety and efficacy of the application of a cosmeceutical formulation, which incorporated growth factors derived from cultured pluripotential stem cells of unfertilized human ovum, in the treatment of photo-damaged facial skin. The use of micro-needling to stem cell-treated skin was evaluated for additional benefit. Material and Methods: Ten subjects in Group 1 with mild-to-moderate photo-damaged skin received the growth factor emulsion to one side of the face and serum to the eyelids/periorbitum and placebo on the contralateral side for twelve (12) weeks. Ten subjects in a separate Group 2 with similar photo-damaged skin received the same growth factor emulsions and serum to both sides of the face and eyelids/periorbitum, but only one side was treated with four micro-needling procedures four weeks apart. Subjects in Group 1 were assessed at baseline, 6 weeks and 12 weeks with the Canfield VISIA Investigator System and standardized 2D photography. Subjects in Group 2 were similarly assessed with the addition of the DermaLab Cortex System. Data analysis compared the p-values with the alpha level for statistical difference. Results: Group 1 subjects demonstrated a beneficial effect by VISIA Analysis on reduction of pigmented spots, UV-light damage with more effective effacement of wrinkles and textural changes after three months compared with that observed on the placebo side. Group 2 subjects demonstrated more improvement by VISIA Analysis in reduction of pigmentations, UV-light damage, porphyrin spots, and wrinkles with more textural smoothness with combined treatments than with cosmeceutical application alone. Cortex Analysis of skin, receiving combined treatments, demonstrated marked improvements in skin elasticity and hydration observed after cosmeceutical application alone. Conclusions: The used growth factor-containing creams and serum have a salutary effect on photodamaged skin whose effects may be further enhanced with the addition of micro-needling without introduction of side-effects or complications. Further investigations with a larger cohort of subjects for longer treatment periods will be needed to confirm and extend these initial findings.

Keywords

Human Growth Factor Cream and Serum, Micro-Needling, Skin Photo-Aging, Safety and Efficacy

Share and Cite:

Sasaki, G. (2015) The Effects of Life Line Facial Cream/Periobitum Serum and Micro-Needling of Photodamaged Skin: A Split-Face Randomized Study. Open Access Library Journal, 2, 1-13. doi: 10.4236/oalib.1101867.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Babu, M. and Wells, A. (2001) Dermal-Epidermal Communication in Wound Healing. Wounds, 13, 183-189.
[2]	Wermeling, D.P., Banks, S.L., Hudson, D.A., et al. (2008) Microneedles Permit Transdermal Delivery of Skin-Impermeant Medications to Humans. Proceedings of the National Academy of Sciences of the United States of America, 105, 2058-2063. http://dx.doi.org/10.1073/pnas.0710355105
[3]	Prausnitz, M.R., Mitragotri, S. and Langer, R. (2004) Current Status and Future Potential of Transdermal Drug Delivery. Nature Reviews Drug Discovery, 3, 115-124. http://dx.doi.org/10.1038/nrd1304
[4]	Fernandes, D. (2002) Percutaneous Collagen Induction: An Alternative to Laser Resurfacing. Aesthetic Surgery Journal, 22, 315-317. http://dx.doi.org/10.1067/maj.2002.126195
[5]	Lifeline Skin Care, Inc. (2013) Controlled Usage Study to Evaluate Efficacy of an Anti-Aging Product. Study Conducted by AMA Laboratories, Inc., New York.
[6]	Lifeline Skin Care, Inc. (2013) Evaluation of the Efficacy of a Topical Skin Care Regimen to Improve Skin Condition. Study Conducted by Bioscreen Testing Services, Inc., Phoenix.
[7]	Liu, B., Earl, H.M., Baban, D., et al. (1995) Melanoma Cell Lines Express VEGF Receptor KDR and Respond to Exogenously Added VEGF. Biochemical and Biophysical Research Communications, 217, 721-727. http://dx.doi.org/10.1006/bbrc.1995.2832
[8]	Lazar-Molnar, E., Hegyesi, H., et al. (2000) Autocrine and Paracrine Regulation by Cytokines and Growth Factors in Melanoma. Cytokine, 12, 547-554. http://dx.doi.org/10.1006/cyto.1999.0614
[9]	Draelos, Z.D. (2007) Exploring the Pitfalls in Clinical Cosmeceutical Research. Journal of Cosmetic Dermatology, 20, 556-558.