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Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies

DOI: 10.4236/oalib.1101830    813 Downloads   1,117 Views  

ABSTRACT

NSAIDs are the most widely used drugs globaly and are very famous for their analgesic, anti-in-flammatory and antipyretic actions. The use of NSAIDs in a variety of cancerous conditions is also approved now because of its versatile pharmacologic actions. In this research based study the use of NSAIDs as a chemointerceptive agent in a variety of cancers has been discussed. We aimed to know about the chemopreventive effects of NSAIDs that are a very diverse group of drugs having a lot of pharmacological actions. Now they are advised to prevent from various types of cancers by its different mechanisms and processes like inhibition of angiogenesis, COX-2 and it potentiates the process of apoptosis which is also a very favourable point for NSAIDs to work as a chemointerceptive agent. Heeding to the results aspirin could intercept from cancer (37%) and other NSAIDs used as acheminterceptive agents (28%). All of the NSAIDs have less side effects as compared to the drugs that are used during chemotherapy. The inhibition of COX-1 enzyme by NSAIDs is (15%) and that of COX-2 (85%). Studies suggested that the most frequent cancer in males is 14.5% of colorectal cancer and 10% prostate cancer while in female the most common cancers are 27% of breast cancer and 15% of colorectal cancer. 30% of ovarian cancer is also very common in many females of elder age groups. It was concluded that NSAIDs are a diverse group of drugs and advised to manipulate as a chemointerceptive agents in a variety of cancers. Besides these studies there are many limitations heeding to the chronic usage of NSAIDs, which should also be considered. The use of NSAIDs as a chemointerceptive agent requires more further experimental studies and needs clinical trials.

Conflicts of Interest

The authors declare no conflicts of interest.

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Ayub, M. and Islam, A. (2015) Prevalence of Nsaids (Non Steroidal Inflammatory Drugs) as a Chemopreventive Agent in Different Types of Cancer: Retrospective Detail Studies. Open Access Library Journal, 2, 1-11. doi: 10.4236/oalib.1101830.

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