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Hemodynamic Forces Effective in Reshaping Vascular Geometry

DOI: 10.4236/oalib.1101688    640 Downloads   876 Views  

ABSTRACT

Besides the medical education, simulations became an attractive diagnostic method in some clinical cases. Recent advances in computerized image processing bring new practices entitled as “patient specific simulation” to the agenda. One of the successful applications which examines hemodynamic forces as a result of the interaction between blood flow and vessel wall constitutes the topic of this study. In this study, the terms and laws which provided a theoretical basis for the hemodynamic forces in circulatory system were evaluated from the biophysical point of view. With this perspective, the concepts of fluid viscosity and blood flow in elastic vessel were emphasized. The impacts of height and vessel diameter differences on flow conditions were discussed in terms of Bernoulli and continuity laws. Viscosity effect and the other factors that may impede the fluid flow were discussed in accordance with Poiseuille’s law. The relation between transmural pressure and dilatation in elastic vessel was evaluated considering Laplace law. Then, the dynamic forces in radial and axial directions occurring during fluid flow were defined. Clinically, it is important to know the interactions between blood and vessel wall endothelia. Current in-vivo methods are not suitable for the measurements of spatial and temporal patterns of these interactions. However, classical engineering method of computational fluid dynamics, recently, took place in medical simulations that made it possible to calculate the hemodynamic parameters for every volume element defined in three-dimensional anatomically realistic vessel model. Patient specific simulations that are believed to be the core of the future project of “clinical diagnostic expert systems” will be an important tool in prescribing patient specific treatment and in the assessment of complication risks. With this perspective in this paper, we discussed the theoretical background and elucidated the role of hemodynamic forces in vascular pathologies.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kızıltan, E. (2015) Hemodynamic Forces Effective in Reshaping Vascular Geometry. Open Access Library Journal, 2, 1-7. doi: 10.4236/oalib.1101688.

References

[1] Bradley, P. (2006) The History of Simulation in Medical Education and Possible Future Directions. Medical Education, 40, 254-262.
http://dx.doi.org/10.1111/j.1365-2929.2006.02394.x
[2] Mıdık, Ö. and Kartal, M. (2010) Simülasyona Dayalı Tıp Eğitimi. Marmara Medical Journal, 23, 389-399.
[3] Van de Vosse, F.N. (2003) Mathematical Modelling of the Cardiovascular System. Journal of Engineering Mathematics, 47, 175-183.
http://dx.doi.org/10.1023/B:ENGI.0000007986.69547.5a
[4] Khader, S.M.A., Zubair Md., P.R., Rao, B.V.R.K. and Kamath, S.G. (2009) A Comparative Study of Transient Flow through Cerebral Aneurysms Using CFD. World Academy of Science, Engineering and Technology, 36, 606-610.
[5] Filipovic, N., Ivanovic, M., Krstajic, D. and Kojic, M. (2011) Hemodynamic Flow Modeling through an Abdominal Aorta Aneurysm Using Data Mining Tools. IEEE Transactions on Information Thechnology in Biomedicine, 15, 189-194.
http://dx.doi.org/10.1109/TITB.2010.2096541
[6] Shojima, M., Oshima, M., Takagi, K., Torii, R., Nagata, K., Shirouzu, I., et al. (2005) Role of the Bloodstream Impacting Force and the Local Pressure Elevation in the Rupture of Cerebral Aneurysms. Stroke, 36, 1933-1938.
http://dx.doi.org/10.1161/01.STR.0000177877.88925.06
[7] Steinman, D.A. (2002) Image-Based Computational Fluid Dynamics Modeling in Realistic Arterial Geometries. Annals of Biomedical Engineering, 30, 483-497.
http://dx.doi.org/10.1114/1.1467679
[8] Pehlivan, F. (2015) Biyofizik. 8th Edition, Pelikan Yayıncılık, Ankara.
[9] Jeong, W. and Rhee, K. (2012) Hemodynamics of Cerebral Aneurysms: Computational Analyses of Aneurysm Progress and Treatment. Computational and Mathematical Methods in Medicine, 2012, Article ID: 782801.
http://dx.doi.org/10.1155/2012/782801
[10] Filipovic, N., Milasinovic, D., Zdravkovic, N., Böckler, D. and Tengg-Kobligk, H. (2011) Impact of Aortic Repair Based on Flow Field Computer Simulation within the Thoracic Aorta. Computer Methods and Programs in Biomedicine, 10, 243-252.
http://dx.doi.org/10.1016/j.cmpb.2011.01.005
[11] Yoganathan, A.P., Cape, E.G., Sung, H.W., Williams, F.P. and Jimoh, A. (1988) Review of Hydrodynamic Principles for the Cardiologist: Applications to the Study of Blood Flow and Jets by Imaging Techniques. Journal of the American College of Cardiology, 12, 1344-1353.
http://dx.doi.org/10.1016/0735-1097(88)92620-4
[12] Simmonds, M.J., Meiselman, H.J. and Baskurt, O.K. (2013) Blood Rheology and Aging. Journal of Geriatric Cardiology, 10, 291-301.
[13] Malek, A.M., Alper, S.L. and Izumo, S. (1999) Hemodynamic Share Stress and Its Role in Atherosclerosis. JAMA, 282, 2035-2042.
http://dx.doi.org/10.1001/jama.282.21.2035
[14] Ai, L., Yu, H., Takabe, W., Paraboschi, A., Yu, F., Kim, E.S., et al. (2009) Optimization of Intravascular Shear Stress Assessment in Vivo. Journal of Biomechanics, 42, 1429-1437.
http://dx.doi.org/10.1016/j.jbiomech.2009.04.021
[15] Torii, R., Oshima, M., Kobayashi, T., Takagi, K. and Tezduyar, T.E. (2007) Influence of Wall Elasticity in Patient-Specific Hemodynamic Simulations. Computers & Fluids, 36, 160-168.
http://dx.doi.org/10.1016/j.compfluid.2005.07.014
[16] Wentzel, J.J., Chatzizisis, Y.S., Gijsen, F.J.H., Giannoglou, G.D., Feldman, C.L. and Stone, P.H. (2012) Endothelial Shear Stress in the Evolution of Coronary Atherosclerotic Plaque and Vascular Remodelling: Current Understanding and Remaining Questions. Cardiovascular Research, 96, 234-243.
http://dx.doi.org/10.1093/cvr/cvs217
[17] Miljkovic, O., Ivanovic, M., Filipovic, N. and Kojic, M. (2008) AI Models of the Hemodynamic Simulation. Journal of the Serbian Society for Computational Mechanics, 2, 59-72.

  
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