Share This Article:

Contemporary Trends in Novel Ophthalmic Drug Delivery System: An Overview

DOI: 10.4236/oalib.1101497    781 Downloads   1,486 Views   Citations

ABSTRACT

One of the most challenging tasks faced by the pharmaceutical researchers is the ophthalmic drug delivery. Their aim is to obtain and maintain a therapeutic level at the site of action for prolonged period of time. Therefore, to sustain drug levels at the target site for a sufficient time, novel drug delivery techniques should be developed. Ophthalmic drug delivery has proved significant advancement for future point of view. This article evaluates a variety of novel systems for ophthalmic drug delivery.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Naveed, S. , Farooq, S. , Abbas, S. , Jawed, S. , Qamar, F. , Hussain, M. and Ali, I. (2015) Contemporary Trends in Novel Ophthalmic Drug Delivery System: An Overview. Open Access Library Journal, 2, 1-10. doi: 10.4236/oalib.1101497.

References

[1] Rajasekaran, A., Sivakumar, V., Karthika, K., Preetha, J.P. and Anirami, T. (2010) Design and Evaluation of Polymeric Controlled Release Natamycin Ocular Inserts. Kathmandu University Journal of Science, Engineering and Technology, 6, 108-115.
http://dx.doi.org/10.3126/kuset.v6i1.3318
[2] Sabitha, K., Sajeeth, C.I. and Santhi, K. (2012) Chitosan Nanoparticles: A Novel Vehicle for the Enhanced Ocular Delivery of Moxifloxacin HCl. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3, 534-548.
[3] Patel, H.A., Patel, J.K., Patel, K.N. and Patel, R.R. (2010) Ophthalmic Drug Delivery System: A Review. Der Pharmacia Lettre, 2, 100-115.
[4] Babizahayev, M.A. (2009) Current Ocular Drug Delivery Challenges For N-Acetylcarnosine: Novel Patented Routes and Modes Of Delivery, Design for Enhancement of Therapeutic Activity and Drug Delivery Relationships. Recent Patents on Drug Delivery & Formulation, 3, 229-265.
http://dx.doi.org/10.2174/187221109789105621
[5] Singh, V., Ahmad, R. and Heming, T. (2011) The Challenges of Ophthalmic Drug Delivery: A Review. International Journal of Drug Discovery, 3, 56-62.
http://dx.doi.org/10.9735/0975-4423.3.1.56-62
[6] Sampath Kumar, K.P., Bhowmik, D., Harish, G., Duraivel, S. and Pragathi Kumar, B. (2012) Ocular Inserts: A Novel Controlled Drug Delivery System. The Pharma Innovation-Journal, 1, 1-16.
[7] Gupta, D. (2011) Review on Ocular Drug Delivery. Dehradun Institute of Technology, Dehradun.
[8] Rajasekaran, A., Arul Kumaran, K.S.G., Karthika, K. and Padma Preetha, J. (2010) A Comparative Review on Conventional and Advanced Ocular Drug Delivery Formulations. International Journal of PharmTech Research, 2, 668-674.
[9] Li, X.M., Cui, Y.D., Lloyd, A.W., Mikhalovsky, S.V., Sandeman, S.R., Howel, C.A. and Liao, L.W. (2008) Polymeric Hydrogels for Novel Contact Lens Based Ophthalmic Drug Delivery System: A Review. Contact Lens & Anterior Eye, 31, 57-64.
http://dx.doi.org/10.1016/j.clae.2007.09.002
[10] Weiner, A.L. and Gilger, B.C. (2010) Advancements in Ocular Drug Delivery. Veterinary Ophthalmology, 13, 395-406.
http://dx.doi.org/10.1111/j.1463-5224.2010.00835.x
[11] Thakur, R.R. and Kashiv, M. (2011) Modern Delivery System for Ocular Drug Formulations: A Comparative Overview W.R.T. Conventional Dosage Forms—Review Paper. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2, 8-18.
[12] Bisht, R. and Durgapal, S. (2011) Potential Advantages of Novel Intracorneal Drug Delivery System in Management of Fungal Keratitis—An Overview. International Journal of Pharmacy and Pharmaceutical Sciences, 3, 12-17.
[13] Giudice, G.L. and Galan, A. (2012) Basic Research and Clinical Application of Drug Delivery Systems for the Treatment of Age-Related Macular Degeneration. In: Ying, G.-S., Ed., Age Related Macular Degeneration—The Recent Advances in Basic Research and Clinical Care, InTech, Croatia, 99-120.
[14] Kalyanwat, R., Gupta, S., Songara, R.K. and Lokwani, P. (2011) Ocular Inserts: An Overview. International Journal of Pharmaceutical Research & Development, 3, 141-148.
[15] Mohammad Zaki, A.J., Patil, S.K., Baviskar, D.T. and Jain, D.K. (2012) Implantable Drug Delivery System: A Review. International Journal of PharmTech Research, 4, 280-292.
[16] Yasukawa, T., Tabata, Y., Kimura, H. and Ogura, Y. (2011) Recent Advances in Intraocular Drug Delivery Systems. Recent Patents on Drug Delivery & Formulation, 5, 1-10.
http://dx.doi.org/10.2174/187221111794109529
[17] Malaekeh-Nilouei, B., Vahabzadeh, S.A. and Mohajeri, S.A. (2013) Preparation of a Molecularly Imprinted Soft Contact Lens as a New Ocular Drug Delivery System for Dorzolamide. Current Drug Delivery, 10, 279-285.
[18] Peng, C.C., Ben Shlomo, A., Mackay, E.O., Plummer, C.E. and Chauhan, A. (2012) Drug Delivery by Contact Lenses in Spontaneously Glaucomatous Dogs. Current Eye Research, 37, 204-211.
http://dx.doi.org/10.3109/02713683.2011.630154
[19] Sindhumol, P.G. and Mohanachandran, P.S. (2011) Formulation and Evaluation of Sodium Cromoglycate Ophthalmic Inserts. International Journal of Drug Formulation & Research, 2, 255-267.
[20] Gupta, S. and Gilhotra, R.M. (2011) Enhancement of Antiglaucoma Potential by Novel Ocular Drug Delivery System. International Journal of Pharmacy and Pharmaceutical Sciences, 3, 55-58.
[21] Shanmugam, S., Ramvignesh, T.R., Sundaramoorthy, K., Agyappan, T. and Vetrichelvan, T. (2011) Design and Evaluation of Novel Ophthalmic Delivery System of Acyclovir for Herpes Simplex Infection. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2, 802-814.
[22] Molokhia, S.A., Sant, H., Simonis, J., Bishop, C.J., Burr, R.M., Gale, B.K. and Ambati, B.K. (2010) The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye. Vision Research, 50, 680-685.
http://dx.doi.org/10.1016/j.visres.2009.10.013
[23] Ramkanth, S., Chetty, C.M., Alagusundaram, M., Angalaparameswari, S., Thiruvengadarajan, V.S. and Gnanaprakash, K. (2009) Design and Evaluation of Diclofenac Sodium Ocusert. International Journal of PharmTech Research, 1, 1219-1223.
[24] Kumar, A., Malviya, R. and Sharma, P.K. (2011) Recent Trends in Ocular Drug Delivery: A Short Review. European Journal of Scientific Research, 3, 86-92.
[25] Tiwari, A. and Shukla, R.K. (2010) Novel Ocular Drug Delivery Systems: An Overview. Journal of Chemical and Pharmaceutical Research, 2, 348-355.
[26] Mythri, G., Kavitha, K., Kumar, M.R. and Singh, S.J. (2011) Novel Mucoadhesive Polymer: A Review. Journal of Applied Pharmaceutical Science, 1, 37-42.
[27] Talegaonkar, S., Azeem, A., Ahmad, F.J., Khar, R.K., Pathan, S.A. and Khan, Z.I. (2008) Microemulsions: A Novel Approach to Enhanced Drug Delivery. Recent Patents on Drug Delivery & Formulation, 2, 238-257.
http://dx.doi.org/10.2174/187221108786241679
[28] Alagusundaram, M., Madhu, S.C.C., Umashankari, K., Badarinath, A.V., Lavanya, C. and Ramkanth, S. (2009) Microspheres as a Novel Drug Delivery System—A Review. International Journal of ChemTech Research, 1, 526-534.
[29] Katteboinaa, S., Chandrasekhar, P. and Balaji, S. (2009) Drug Nanocrystals: A Novel Formulation Approach to Poorly Soluble Drugs. International Journal of PharmTech Research, 1, 682-694.
[30] Hari, B.N.V., Kalaimagal, K., Porkodi, R., Gajula, P.K. and Ajay, J.Y. (2012) Dendrimer: Globular Nanostructured Materials for Drug Delivery. International Journal of ChemTech Research, 4, 432-451.
[31] Han, S., Shen, J., Gan, Y., Geng, H., Zhang, X., Zhu, C. and Gan, L. (2010) Novel Vehicle Based on Cubosomes for Ophthalmic Delivery of Flurbiprofen with Low Irritancy and High Bioavailability. Acta Pharmacologica Sinica, 31, 990-998.
http://dx.doi.org/10.1038/aps.2010.98
[32] Nikam, V.K., Kotade, K.B., Gaware, V.M., Dolas, R.T., Dhamak, K.B., Somwanshi, S.B., et al. (2011) Iontophoresis in Drug Delivery: History and Application. Pharmacologyonline, 3, 543-561.
[33] Vodithala, S., Khatry, S., Shastri, N. and Sadanandam, M. (2010) Formulation and Evaluation of Ion Activated Ocular Gels of Detorolac Tromethamine. International Journal of Current Pharmaceutical Research, 2, 33-38.
[34] Rathore, K.S. (2010) In Situ Gelling Ophthalmic Drug Delivery System: An Overview. International Journal of Pharmacy and Pharmaceutical Sciences, 2, 30-34.
[35] Kumar, L., Singh, R.P., Gupta, S. and Kumar, D. (2011) In Situ Gel: A Novel System for Ocular Drug Delivery. International Journal of Pharmaceutical Sciences Review and Research, 9, 83-91.
[36] Champalal, K.D. and Poddar Sushilkumar, S. (2012) Current Status of Ophthalmic In-Situ Forming Hydrogel. International Journal of Pharmacy and Biological Sciences, 3, 372-388.
[37] Hiremath, S.S.P., Dasankoppa, F.S., Nadaf, A., Jamakandi, V.G., Mulla, J.S., Sreenivas, S.A., Sholapur, H.N., Aezazahmed and Nanjundaswamy, N.G. (2008) Formulation and Evaluation of a Novel in Situ Gum Based Ophthalmic Drug Delivery System of Linezolid. Scientia Pharmaceutica, 76, 515-532.
http://dx.doi.org/10.3797/scipharm.0803-17
[38] Varshoaz, J., Tabbakhian, M. and Salmani, Z. (2008) Designing of a Thermosensitive Chitosan/Poloxamer in Situ Gel for Ocular Delivery of Ciprofloxacin. The Open Drug Delivery Journal, 2, 61-70.
http://dx.doi.org/10.2174/1874126600802010061
[39] Ramaa, C.S., Mohan, R., Mundada, A.S. and Kadam, V.J. (2008) Advances in Contemporary Research. Retrometabolism Based Drug Targeting—Soft Drug Approach. Indian Journal of Chemistry, 47B, 721-723.
[40] Allen, L.V., Popwich, N.G. and Ansel, H.C. (2005) Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 8th Edition, Lippincot Williams & Wilkins, Philadelphia, 652-662.
[41] Hughes, P.M., Olejnik, O., Chang-Lin, J.E. and Wilson, C.G. (2005) Topical and Systemic Drug Delivery to the Posterior Segments. Advanced Drug Delivery Reviews, 57, 2010-2032.
http://dx.doi.org/10.1016/j.addr.2005.09.004

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.