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Medical Science Turns Deadly Substances into Life Saving Ones: Snake Venom as a Treatment Option

DOI: 10.4236/oalib.1101323    1,192 Downloads   1,783 Views  

ABSTRACT

Background: The word “venom” has always been taken as the synonym for poison or a vile liquid with catastrophic effects. Out of several different venomous creatures, snakes have perked special interest of scientists and researchers in this matter across the world. Many scientists and researchers around the world are trying to explore and put forward the positive aspects of snake venom and in the past years they have come to the conclusion that snake venom has some potential effects against serious ailments like cancer, diabetes and hypertension. Objective: The aim of current research is to make people realize that the snake venom, despite being a deadly poison, may prove to be a treatment option in several rather incurable diseases. Methodology: A survey was conducted that was based on 200 (n = 200) people including common public, medical students and health practitioners to know their general opinion and to awake people regarding the beneficial aspects of snake venom. Result: The study shows that about 48.5% of them think that snake venom can be used for beneficial purposes, while 31% think of it only as a deadly poison, whereas 20.5% of the people have absolutely no idea about it. The researchers believe that proteins like “eristostatin” and “contortrostatin” found in the venoms of Asian sand viper and South American rattlesnake respectively have the ability to fight against cancers. “Mambalgins” (from the venom of black mamba) are believed to have analgesic and anti-inflammatory effects. Venoms are also being used in skin care products. Conclusion: We conclude that medical practitioners should come forward and explore more on this topic, so that maybe snake venom can prove to be another successful source of medication for several serious diseases.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Gul, S. , Ahmad, N. , Iqbal, U. and Rubab, B. (2015) Medical Science Turns Deadly Substances into Life Saving Ones: Snake Venom as a Treatment Option. Open Access Library Journal, 2, 1-9. doi: 10.4236/oalib.1101323.

References

[1] Moskowitz, C. (2008) Why We Fear Snakes? Live Science, 1.
http://www.livescience.com/2348-fear-snakes.html
[2] Vyas, V.K., Brahmbhatt, K., Bhatt, H. and Parmar, U. (2013) Therapeutic Potential of Snake Venom in Cancer Therapy: Current Perspectives. Asian Pacific Journal of Tropical Biomedicine, 3, 156-162.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627178/#!po=71.8750
[3] Perkel, J.M. (2008) Snake Venomics Uncoils Venom Composition, Evolution. Journal of Proteome, 7, 3067.
http://pubs.acs.org/doi/abs/10.1021/pr800479x
http://dx.doi.org/10.1021/pr800479x
[4] Liu, Y., Wang, X.J., Wu, Z., Chen, P., Nie, D.S., Yi, J.M., Yi, J.Z. and Liu, Z.G. (2012) Electrophysiological and Proteomic Studies of Protobothrops mangshensis Venom Revealed Its High Bioactivities and Toxicities. Journal of Integrated Omics, 2, 132-139.
http://www.jiomics.com/index.php/jio/article/view/114/106
[5] Paulchamy, C. (2009) Pharmacological Perspectives of Snake Venoms from Viperidae Family. The Internet Journal of Pharmacology, 8, 1.
http://ispub.com/IJPHARM/8/2/6664
[6] Fox News (2012) Snake Venom Could Be Used to Treat Cancer, Diabetes.
http://www.foxnews.com/health/2012/09/20/snake-venom-could-be-used-to-develop-drugs-for-cancer-diabetes
[7] Cavaliere, V. (2012) Snake Venom Could Hold Cure for Cancer, Diabetes: Study. New York Daily News, 1.
http://www.nydailynews.com/life-style/health/snake-venom-hold-cures-cancer-diabetes-study-article-1.1162830
[8] Jones, T. (2012) Insight into Snake Venom Evolution Could Aid Drug Discovery. Planet Earth Online, NERC-Science of the Environment, 1.
http://planetearth.nerc.ac.uk/news/story.aspx?id=1291&cookieConsent=A
[9] AAP (2012) Snake Venom Could Treat Cancer. The West Australian, 21 September.
https://au.news.yahoo.com/thewest/lifestyle/a/14914579/snake-venom-could-treat-cancer
[10] Hailey, S., Adams, E., Peng, R., Wong, A. and McLane, M.A. (2013) Effect of the Disintegrin Eristostatin on Melanoma-Natural Killer Cell Interactions. Toxicon, 6, 83-93.
http://www.sciencedirect.com/science/article/pii/S0041010112007751
[11] The Economist (2013) Snake Venom Is Being Used to Cure, Rather than Kill. The Economist, 5 January.
http://www.economist.com/news/science-and-technology/21569015-snake-venom-being-used-cure-rather-kill-toxic-medicine
[12] Pyrko, P., Wang, W., Markland, F.S., Swenson, S.D., Schmitmeier, S., Schönthal, A.H. and Chen, T.C. (2005) The Role of Contortrostatin, a Snake Venom Disintegrin, in the Inhibition of Tumor Progression and Prolongation of Survival in a Rodent Glioma Model. Journal of Neurosurgery, 103, 526-537.
http://www.ncbi.nlm.nih.gov/pubmed/16235686
[13] Swenson, S., Costa, F., Ernst, W., Fujii, G. and Markland, F.S. (2005) Contortrostatin, a Snake Venom Disintegrin with Anti-Angiogenic and Anti-Tumor Activity. Pathophysiology of Haemostasis and Thrombosis, 34, 169-176.
http://www.ncbi.nlm.nih.gov/pubmed/16707922
[14] Selistre-de-Araujo, H.S., Pontes, C.L.S., Montenegro, C.F. and Martin, A.C.B.M. (2010) Snake Venom Disintegrins and Cell Migration. Toxins (Basel), 2, 2606-2621.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153172/#__ffn_sectitle
[15] Marcinkiewicz, C. (2005) Functional Characteristic of Snake Venom Disintegrins: Potential Therapeutic Implication. Current Pharmaceutical Design, 11, 815-827.
[16] Zicha, J., Dobesová, Z. and Kunes, J. (2006) Antihypertensive Mechanisms of Chronic Captopril or N-Acetylcysteine Treatment in L-NAME Hypertensive Rats. Hypertension Research, 29, 1021-1027.
http://www.nature.com/hr/journal/v29/n12/pdf/hr2006140a.pdf
[17] James Mitchell Crow (2012) Venomous Drugs: Captopril. New Scientist, 214, 35.
http://www.sciencedirect.com/science/article/pii/S0262407912611713
[18] Bryan, J. (2009) From Snake Venom to ACE Inhibitor—The Discovery and Rise of Captopril. The Pharmaceutical Journal, 282, 455.
http://www.pharmaceutical-journal.com/news-and-analysis/news/from-snake-venom-to-ace-inhibitor-the-discovery-and-rise-of-captopril/10884359.article
[19] Miguel-Carrasco, J.L., Zambrano, S., Blanca, A.J., Mate, A. and Vázquez, C.M. (2010) Captopril Reduces Cardiac Inflammatory Markers in Spontaneously Hypertensive Rats by Inactivation of NF-kB. Journal of Inflammation, 7, 21.
http://www.journal-inflammation.com/content
[20] Cossins, D. (2013) From Toxins to Therapeutics. The Scientist, 1.
http://www.the-scientist.com/?articles.view/articleNo/34745/title/From-Toxins-to-Therapeutics
[21] Shen, H. (2012) Deadly Snake Venom Delivers Pain Relief. Nature, 1.
http://www.nature.com/news/deadly-snake-venom-delivers-pain-relief-1.11526
[22] Woolf, C.J. (2013) Pain: Morphine, Metabolites, Mambas and Mutations. The Lancet Neurology, 12, 18-20.
http://www.sciencedirect.com/science/article/pii/S1474442212702879
[23] Keber, P. (2013) Using Snake Venom for Medicine. The Weather Network, 1.
http://www.theweathernetwork.com/news/articles/using-snake-venom-for-medicine/9860/
[24] Rally, D.T. (2010) Viper Room: Is Snake Venom the Cure for Wrinkles? Elle Canada, 1.
http://www.ellecanada.com/beauty/viper-room-is-snake-venom-the-cure-for-wrinkles/a/36441/2#.VAd8OMWSw2A
[25] Bonnier Corporation (2008) Evolution’s Most Effective Killer: Snake Venom. Popular Science, 272, 116.
http://www.popsci.com/scitech/article/2008-03/evolution%E2%80%99s-most-effective-killer-snake-venom
[26] McCleary, R.J. and Kini, R.M. (2013) Non-Enzymatic Proteins from Snake Venoms: A Gold Mine of Pharmacological Tools and Drug Leads. Toxicon, 62, 56-74.
[27] dos Santos, J.I., Cintra-Francischinelli, M., Borges, R.J., Fernandes, C.A., Pizzo, P., Cintra, A.C., Braz, A.S., Soares, A.M. and Fontes, M.R. (2011) Structural, Functional, and Bioinformatics Studies Reveal a New Snake Venom Homologue Phospholipase A2 Class. Proteins, 79, 61-78.
http://www.ncbi.nlm.nih.gov/pubmed/20878713

  
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