Particle Simulation of Skin Basal Layer Formation

DOI: 10.4236/jbm.2016.43006   PDF   HTML     1,692 Downloads   2,101 Views   Citations

Abstract

There has been increasing concern regarding the cosmetic aspects of skin in recent years. Computational simulation can be useful in understanding the mechanism underlying skin formation. The bottom of the epidermis is called the basal layer and is very undulation. In this study, we focus on the basal layer formation. We created a particle model, which forms an undulation basal layer and regenerates the basal layer formation by numerical simulation. At first, two-dimensional basal layer formation without epidermal turnover was simulated. The results showed film shape changes and the stability, as a layer in the process of long-time with an increase and decrease of basal cells. Next, the model was applied to three-dimensional basal layer formation with epidermal turnover. As the structure of the basal layer was deformed, the upper structure of the epidermis comprising the cells divided from the basal layer also became irregular. The simulation results accurately represented and reproduced the three-dimensional basal layer formation and epidermis turnover process.

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Nagayama, K. , Kurihara, T. , Amano, Y. and Tanahashi, M. (2016) Particle Simulation of Skin Basal Layer Formation. Journal of Biosciences and Medicines, 4, 33-37. doi: 10.4236/jbm.2016.43006.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Querleux, B. (2014) Computational Biophysics of the Skin. Pan Stanford Publishing.
[2] Sütterlin, T., Huber, S., Dickhaus, H. and Grabe, N. (2009) Modeling Multi-Cellular Behavior in Epidermal Tissue Homeostasis via Finite State Machines in Multi-Agent Systems. Bioinformatics, 25, 2057-2063. http://dx.doi.org/10.1093/bioinformatics/btp361
[3] Hirashima, T., Hosokawa, Y., Iino, T. and Nagayama, M. (2013) On Fundamental Cellular Processes for Emergence of Collective Epithelial Movement. Biology Open, 2, 600-666. http://dx.doi.org/10.1242/bio.20134523
[4] Adra, S., Sun, T., MacNeil, S., Holcombe, M. and Smallwood, R. (2010) Development of a Three Dimensional Multiscale Computational Model of the Human Epidermis. Open Journal PLoS ONE, 5, e8511. http://dx.doi.org/10.1371/journal.pone.0008511
[5] Nagayama, K., Nitta, J. and Miura, I. (2009) Numerical Analysis on Angiogenesis in Cancer Using a Particle Model. Theoretical and Applied Mechanics Japan, 58, 321-324.
[6] Hashiguchi, S. and Nagayama, K. (2011) Construction of a Hair Formation Analysis Method Using the Particle Model, 2011 Bioengineering Conference, 23th Japan Society of Mechanical Engineers, Japan, 355-356.
[7] Nagayama, K., Matsuoka, S., Morisaki, N. and Taguchi, H. (2015) 3D Numerical Simulation of Hair Formation Process Using a Particle Model. Open Journal of Regenerative Medicine. http://file.scirp.org/Html/1-2390044_53849.htm
[8] Uehara, T., Nagayama, K., Amano, Y. and Tanahashi, M. (2013) Numerical Simulation of Epidermis Formation Using Particle Model. The Second BMIRC International Symposium on Frontiers in Computational Systems Biology and Bioengineering, Japan, 30 January 2013.
[9] Amano, Y., Uehara, T., Tanahashi, M. and Nagayama, K. (2012) An Epidermal Turnover Model Predicts Undulation Skin Tone with Aging. SY01.01ICBS (World Congress on the International Society for Biophysics and Imaging of the Skin), Copenhagen, 29 November 2012.
[10] Nagayama, K., Uehara, T., Amano, Y. and Tanahashi, M. (2015) 3D Numerical Simulation of Epidermis Turnover Process Using a Particle Model. Journal of Biosciences and Medicines. http://dx.doi.org/10.4236/jbm.2015.33007
[11] Shimizu, H.S. (2011) Textbook of Modern Dermatology. Nakayama-shoten Co. 38 , Japan.
[12] Clayton, E., Doupe, P.D., Klein, M.A., Winton, J.D., Simons, D.B. and Jones, H.P. (2007) A Single Type of Progenitor Cell Maintains Normal Epidermis. Nature, 446, 185-189. http://dx.doi.org/10.1038/nature05574
[13] Jones, H.P., Simons, D.B. and Watt, M.F. (2007) Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell Review, 1, 371-381. http://dx.doi.org/10.1016/j.stem.2007.09.014

  
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