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One-Pot Synthesis of Imidazolidine-2-Thiones, Hydantoins and Thiohydantoins under Solvent-Free and Grinding Conditions

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DOI: 10.4236/oalib.1100705    1,361 Downloads   1,831 Views   Citations

ABSTRACT

A convenient, environmentally friendly and mild green synthesis of imidazolidine-2-thiones, hy-dantoin and thiohydantoin derivatives was developed by the one-pot reaction of benzils, urea or thiourea derivatives, and strong base at with grinding. The key advantages are the short reaction times, excellent yields, simple workup, and easy purification in the solvent-free condition. The present method aimed to overcome the limitations and drawbacks of the reported methods such as hard work-up, low yield, hazardous solvent and long reaction time.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ghanbari, M. , Roohi, Z. and Safari, J. (2014) One-Pot Synthesis of Imidazolidine-2-Thiones, Hydantoins and Thiohydantoins under Solvent-Free and Grinding Conditions. Open Access Library Journal, 1, 1-5. doi: 10.4236/oalib.1100705.

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