Optimization of the Extraction Technology of Chlorogenic Acid in Honeysuckle by Response Surface Method


The ultrasound-assisted extraction of chlorogenic acid from honeysuckle was modeled using response surface methodology. A three-level-three-factor Box–Behnken design was employed to optimize three extraction variables, including extraction temperature (X1), ethanol concentration (X2), and soak time (X3), for the achievement of high extraction yield of the chlorogenic acid. The optimized conditions are extract temperature of 80℃, ethanol concentration of 70.37%, soak time of 9.35 h. Under this optimized conditions, the experimental yield of chlorogenic acid is 1.918%, which is well matched with the predicted yield of 1.929%.

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Cui, T. , Wang, C. , Shan, C. and Wu, P. (2014) Optimization of the Extraction Technology of Chlorogenic Acid in Honeysuckle by Response Surface Method. Open Access Library Journal, 1, 1-9. doi: 10.4236/oalib.1100941.

Conflicts of Interest

The authors declare no conflicts of interest.


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